Tenofovir disoproxil fumarate


Entry
D01982                      Drug                                   
Name
Tenofovir disoproxil fumarate (JAN/USAN);
Viread (TN)
  Abbr
TDF
Product
VIREAD (Gilead Sciences)
  Generic
TENOFOVIR DISOPROXIL FUMARATE (Apotex Corp.), TENOFOVIR DISOPROXIL FUMARATE (Aurobindo Pharma Limited), TENOFOVIR DISOPROXIL FUMARATE (AvKARE), TENOFOVIR DISOPROXIL FUMARATE (AvPAK), TENOFOVIR DISOPROXIL FUMARATE (Camber Pharmaceuticals), TENOFOVIR DISOPROXIL FUMARATE (Cipla USA), TENOFOVIR DISOPROXIL FUMARATE (DOH CENTRAL PHARMACY), TENOFOVIR DISOPROXIL FUMARATE (NorthStar RxLLC), TENOFOVIR DISOPROXIL FUMARATE (Quinn Pharmaceuticals), TENOFOVIR DISOPROXIL FUMARATE (REMEDYREPACK), TENOFOVIR DISOPROXIL FUMARATE (Strides Pharma Science Limited), TENOFOVIR DISOPROXIL FUMARATE (Chartwell RX), TENOFOVIR DISPROXIL FUMARATE (Macleods Pharmaceuticals Limited), TENOFOVIR DISPROXIL FUMARATE (Major Pharmaceuticals)
Formula
C19H30N5O10P. C4H4O4
Exact mass
635.184
Mol weight
635.5149
Structure
Simcomp
Class
Antiviral
 DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
 DG03107  Anti-HIV agent
  DG01656  HIV reverse transcriptase inhibitor
Remark
Therapeutic category: 6250
ATC code: J05AF07
Chemical structure group: DG01223
Product (DG01223): D01982<JP/US> D10605<JP/US>
Product (mixture): D02297<JP/US> D10571<US> D10756<JP/US> D10851<US> D11392<US> D11395<US> D11396<US>
Efficacy
Antiviral, Reverse transcriptase inhibitor
  Disease
HIV-1 infection [DS:H01563]
Chronic Hepatitis B [DS:H00412]
Comment
Active form of prodrug: Tenofovir [CPD:C17407]
Target
HBV reverse transcriptase [KO:K21037]
HIV-1 reverse transcriptase [KO:K24802]
  Pathway
ko03230  Viral genome structure
ko03240  Viral replication
ko03250  Viral life cycle - HIV-1
ko05161  Hepatitis B
Interaction
Structure map
map07044  Antiviral agents
map07053  Anti-HIV agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF07 Tenofovir disoproxil
      D01982  Tenofovir disoproxil fumarate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-hepatitis B (HBV) Agents
   Tenofovir
    D01982  Tenofovir disoproxil fumarate (JAN/USAN)
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)
   Tenofovir
    D01982  Tenofovir disoproxil fumarate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D01982  Tenofovir disoproxil fumarate (JAN/USAN)
Drug groups [BR:br08330]
 Antiviral
  DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
   DG01223  Tenofovir
    D01982  Tenofovir disoproxil fumarate
  DG03107  Anti-HIV agent
   DG01656  HIV reverse transcriptase inhibitor
    DG01223  Tenofovir
     D01982  Tenofovir disoproxil fumarate
Drug classes [BR:br08332]
 Antiviral
  DG03107  Anti-HIV agent
   D01982  Tenofovir disoproxil fumarate
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   HBV reverse transcriptase inhibitor
    D01982  Tenofovir disoproxil fumarate (JAN/USAN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Genome replication inhibitor
   HBV reverse transcriptase inhibitor
    D01982  Tenofovir disoproxil fumarate (JAN/USAN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01982
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01982
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01982
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01982
Prodrugs [br08324.html]
 D01982
Drug groups [BR:br08330]
 Antiviral
  DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
   DG01223  Tenofovir
  DG03107  Anti-HIV agent
   DG01656  HIV reverse transcriptase inhibitor
    DG01223  Tenofovir
Other DBs
CAS: 202138-50-9
PubChem: 7849044
ChEBI: 63718
LigandBox: D01982
NIKKAJI: J1.996.151F
KCF data

ATOM        43
            1   C6a C    30.8992  -18.5945
            2   C2b C    32.1576  -19.2936
            3   C2b C    33.3460  -18.5945
            4   C6a C    34.5345  -19.2936
            5   O6a O    35.7928  -18.5945
            6   O6a O    29.7108  -19.2936
            7   O6a O    30.8992  -17.1963
            8   O6a O    34.5345  -20.6917
            9   C8y C    26.5368  -16.8840
            10  C8y C    26.5368  -15.4243
            11  N4y N    25.2162  -17.3012
            12  N5x N    27.7880  -17.5096
            13  N5x N    25.2162  -15.0073
            14  C8y C    27.7880  -14.7987
            15  C8x C    24.3820  -16.1889
            16  C8x C    28.9697  -16.8840
            17  N5x N    28.9697  -15.4243
            18  N1a N    27.7880  -13.4085
            19  C1b C    25.2162  -18.6945
            20  C1c C    24.0155  -19.3876
            21  O2a O    22.8023  -18.6870
            22  C1b C    21.5805  -19.3928
            23  P1b P    20.3622  -18.6904
            24  O2b O    19.1554  -17.9937
            25  O2b O    19.6691  -19.8908
            26  O3b O    21.0616  -17.4784
            27  C1b C    19.1554  -16.5955
            28  C1b C    19.6691  -21.2890
            29  O7a O    17.9438  -15.8681
            30  C7a C    16.7329  -16.5671
            31  O7a O    15.5220  -15.8681
            32  C1c C    14.3112  -16.5671
            33  C1a C    13.1003  -15.8681
            34  O7a O    18.4331  -22.0200
            35  C7a C    17.2222  -21.3209
            36  O7a O    16.0114  -22.0200
            37  C1c C    14.8006  -21.3209
            38  C1a C    13.5897  -22.0200
            39  O6a O    16.7329  -17.9651
            40  C1a C    14.3112  -17.9652
            41  O6a O    17.2222  -19.9230
            42  C1a C    14.8006  -19.9229
            43  C1a C    24.0154  -20.7900
BOND        43
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 1
            5     1   6 1
            6     1   7 2
            7     4   8 2
            8    10  13 1
            9    10  14 1
            10   11  15 1
            11   12  16 2
            12   14  17 2
            13   13  15 2
            14   16  17 1
            15    9  10 2
            16    9  11 1
            17    9  12 1
            18   14  18 1
            19   11  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   23  25 1
            26   23  26 2
            27   24  27 1
            28   25  28 1
            29   27  29 1
            30   29  30 1
            31   30  31 1
            32   31  32 1
            33   32  33 1
            34   28  34 1
            35   34  35 1
            36   35  36 1
            37   36  37 1
            38   37  38 1
            39   30  39 2
            40   32  40 1
            41   35  41 2
            42   37  42 1
            43   20  43 1 #Up