| Entry |
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| Name | Erythromycin lactobionate (JP18/USP); Erythrocin (TN) | ||||||||||
| Product | ERYTHROCIN LACTOBIONATE (Hospira) | ||||||||||
| Generic | ERYTHROMYCIN LACTOBIONATE (Exela Pharma Sciences), ERYTHROCIN LACTOBIONATE (Hospira), ERYTHROMYCIN LACTOBIONATE (Nexus Pharamaceuticals) | ||||||||||
| Formula | C37H67NO13. C12H22O12 | ||||||||||
| Exact mass | 1091.5724 | ||||||||||
| Mol weight | 1092.2227 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Class | Antibacterial DG01551 Macrolide antibiotic DG01874 14-membered ring macrolide antibiotic Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate Metabolizing enzyme inhibitor DG02852 CYP3A/CYP3A4 inhibitor Transporter inhibitor DG01622 ABCB1 inhibitor | ||||||||||
| Remark |
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| Efficacy | Antibacterial, Protein biosynthesis inhibitor | ||||||||||
| Disease | Diphtheria [DS:H00343] Gonorrhea [DS:H00315] Legionnaires' disease [DS:H00311] Bacterial endocarditis [DS:H00334] | ||||||||||
| Target | 50S ribosomal subunit | ||||||||||
| Pathway |
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| Metabolism | Enzyme: CYP3A [HSA:1576 1577 1551] | ||||||||||
| Interaction | CYP inhibition: CYP3A [HSA:1576 1577 1551] Transporter inhibition: ABCB1 [HSA:5243] | ||||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] D DERMATOLOGICALS D10 ANTI-ACNE PREPARATIONS D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE D10AF Antiinfectives for treatment of acne D10AF02 Erythromycin D02009 Erythromycin lactobionate (JP18/USP) <JP/US> J ANTIINFECTIVES FOR SYSTEMIC USE J01 ANTIBACTERIALS FOR SYSTEMIC USE J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS J01FA Macrolides J01FA01 Erythromycin D02009 Erythromycin lactobionate (JP18/USP) <JP/US> S SENSORY ORGANS S01 OPHTHALMOLOGICALS S01A ANTIINFECTIVES S01AA Antibiotics S01AA17 Erythromycin D02009 Erythromycin lactobionate (JP18/USP) <JP/US> USP drug classification [BR:br08302] Antibacterials Macrolides Erythromycin D02009 Erythromycin lactobionate (JP18/USP) Dermatological Agents Topical Anti-infectives Antibacterials, dermatological Erythromycin D02009 Erythromycin lactobionate (JP18/USP) Ophthalmic Agents Ophthalmic Anti-Infectives Antibacterials, Ophthalmic Erythromycin D02009 Erythromycin lactobionate (JP18/USP) Therapeutic category of drugs in Japan [BR:br08301] 6 Agents against pathologic organisms and parasites 61 Antibiotics 614 Acting mainly on gram-positive bacteria and mycoplasma 6141 Erythromycins D02009 Erythromycin lactobionate (JP18/USP) Drug groups [BR:br08330] Antibacterial DG01551 Macrolide antibiotic DG01874 14-membered ring macrolide antibiotic DG00436 Erythromycin D02009 Erythromycin lactobionate Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG00436 Erythromycin D02009 Erythromycin lactobionate Metabolizing enzyme inhibitor DG02852 CYP3A/CYP3A4 inhibitor DG00436 Erythromycin D02009 Erythromycin lactobionate Transporter inhibitor DG01622 ABCB1 inhibitor DG00436 Erythromycin D02009 Erythromycin lactobionate Drug classes [BR:br08332] Antibacterial DG01551 Macrolide antibiotic D02009 Erythromycin lactobionate Antimicrobials [BR:br08307] Antibacterials Protein biosynthesis inhibitor Macrolide D02009 Erythromycin lactobionate (JP18/USP) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D02009 Erythromycin lactobionate Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D02009 Drug transporters D02009 Drug groups [BR:br08330] Antibacterial DG01551 Macrolide antibiotic DG01874 14-membered ring macrolide antibiotic DG00436 Erythromycin Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG00436 Erythromycin Metabolizing enzyme inhibitor DG02852 CYP3A/CYP3A4 inhibitor DG00436 Erythromycin Transporter inhibitor DG01622 ABCB1 inhibitor DG00436 Erythromycin Antimicrobials abbreviations [BR:br08327] Antibacterials Protein biosynthesis inhibitor Macrolide DG00436 Erythromycin | ||||||||||
| Other DBs |
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| KCF data | ATOM 75 1 C1y C 35.9989 -17.5847 2 C1y C 35.9989 -18.9757 3 C1y C 37.2044 -19.6713 4 C1y C 38.3636 -18.9757 5 O2x O 38.3636 -17.5847 6 C1y C 37.2044 -16.9355 7 O2a O 37.2044 -15.5446 8 C1c C 38.3636 -14.8490 9 C1c C 39.5692 -15.5446 10 C1b C 40.7747 -14.8490 11 O1a O 41.9803 -15.5446 12 C1c C 38.3636 -12.9015 13 C1c C 39.5692 -12.2060 14 O1a O 37.2044 -12.2060 15 C6a C 40.7747 -12.9015 16 O1a O 39.5692 -10.8614 17 O6a O 41.9803 -12.2060 18 O6a O 40.7747 -14.2925 19 O1a O 39.5692 -16.9355 20 C1b C 39.5692 -19.6713 21 O1a O 40.7747 -18.9757 22 O1a O 37.2044 -21.0623 23 O1a O 34.7933 -19.6713 24 O1a O 34.7933 -16.9355 25 C1y C 25.9003 -13.1765 26 C1z C 25.9003 -11.8133 27 C1y C 24.7162 -13.8524 28 O2a O 27.8815 -13.8928 29 C1x C 24.7162 -11.1317 30 O1a O 26.9284 -10.8256 31 C1a C 27.1826 -12.2464 32 C1y C 24.7162 -15.2156 33 C1a C 23.7455 -12.8307 34 C1y C 29.4593 -13.1780 35 C1y C 24.7162 -9.7627 36 O2a O 25.4556 -16.5730 37 C1y C 23.5436 -15.8973 38 C1y C 30.6274 -13.8692 39 O2x O 29.4713 -11.8153 40 C5x C 23.5436 -9.0868 41 C1a C 25.9003 -9.0868 42 C1y C 26.9716 -16.9909 43 C7x C 22.3595 -15.2156 44 C1a C 23.5436 -17.2603 45 C1y C 31.8829 -13.2076 46 O1a O 30.6183 -15.2369 47 C1y C 30.6617 -11.1510 48 C1y C 22.3595 -9.7627 49 O5x O 23.5436 -7.7236 50 C1x C 26.9716 -18.3484 51 O2x O 28.1558 -16.3094 52 O7x O 22.3595 -13.8524 53 O6a O 21.3024 -16.1629 54 C1x C 31.8273 -11.8500 55 N1c N 32.9858 -13.8960 56 C1a C 30.6814 -9.7905 57 C1y C 22.3595 -11.1317 58 C1a C 21.1812 -9.0868 59 C1z C 28.1558 -19.0358 60 C1y C 29.3282 -16.9909 61 C1y C 21.1812 -13.1765 62 C1z C 21.1812 -11.8133 63 O1a O 23.5436 -11.8133 64 C1y C 29.3282 -18.3484 65 O2a O 28.1558 -20.3586 66 C1a C 29.5998 -20.0178 67 C1a C 30.5124 -16.3152 68 C1b C 20.0027 -13.8524 69 C1a C 19.9335 -12.3792 70 O1a O 19.9335 -11.1260 71 O1a O 30.5124 -19.0358 72 C1a C 29.2532 -21.3175 73 C1a C 20.0377 -14.9729 74 C1a C 34.2321 -13.1885 75 C1a C 32.9764 -15.2577 BOND 77 1 1 2 1 2 2 3 1 3 3 4 1 4 4 5 1 5 5 6 1 6 1 6 1 7 6 7 1 #Down 8 8 7 1 #Up 9 8 9 1 10 9 10 1 11 10 11 1 12 8 12 1 13 12 13 1 14 12 14 1 #Down 15 13 15 1 16 13 16 1 #Up 17 15 17 1 18 15 18 2 19 9 19 1 #Up 20 4 20 1 #Down 21 20 21 1 22 3 22 1 #Down 23 2 23 1 #Down 24 1 24 1 #Up 25 25 26 1 26 25 27 1 27 25 28 1 #Down 28 26 29 1 29 26 30 1 #Up 30 26 31 1 #Down 31 27 32 1 32 27 33 1 #Down 33 34 28 1 #Down 34 29 35 1 35 32 36 1 #Down 36 32 37 1 37 34 38 1 38 34 39 1 39 35 40 1 40 35 41 1 #Down 41 42 36 1 #Down 42 37 43 1 43 37 44 1 #Up 44 38 45 1 45 38 46 1 #Up 46 39 47 1 47 40 48 1 48 40 49 2 49 42 50 1 50 42 51 1 51 43 52 1 52 43 53 2 53 45 54 1 54 45 55 1 #Down 55 47 56 1 #Down 56 48 57 1 57 48 58 1 #Up 58 50 59 1 59 51 60 1 60 52 61 1 61 57 62 1 62 57 63 1 #Up 63 59 64 1 64 59 65 1 #Down 65 59 66 1 66 60 67 1 #Up 67 61 68 1 #Down 68 62 69 1 #Down 69 62 70 1 #Up 70 64 71 1 #Down 71 65 72 1 72 68 73 1 73 47 54 1 74 60 64 1 75 61 62 1 76 55 74 1 77 55 75 1 |