Entry

D02086                      Drug

Name

Lidocaine hydrochloride (JAN/USP);
Dalcaine (TN);
Xylocaine (TN)

Product

LIDOCAINE HCI (HF Acquisition Co LLC), LIDOCAINE HCI AND DEXTROSE (HF Acquisition Co LLC), LIDOCAINE HCI AND DEXTROSE (HF Acquisition Co LLC), XYLOCAINE (General Injectables & Vaccines), XYLOCAINE (Henry Schein), AKTEN (Akorn), LIDOCAINE HYDROCHLORIDE AND DEXTROSE (Baxter Healthcare Corporation), XYLOCAINE (Cardinal Health), XYLOCAINE (Fresenius Kabi USA), LIDOCAINE (Fresenius Kabi USA), XYLOCAINE (Fresenius Kabi USA), XYLOCAINE (General Injectables and Vaccines), XYLOCAIN (LIDOCAINE HCL ) (HF Acquisition Co LLC)

Generic

0.5% LIDOCAINE HCL (HF Acquisition Co LLC), LIDOCAINE HCI (HF Acquisition Co LLC), LIDOCAINE HCI (HF Acquisition Co LLC), LIDOCAINE HCI (HF Acquisition Co LLC), LIDOCAINE HCI (HF Acquisition Co LLC), LIDOCAINE HCI (HF Acquisition Co LLC), LIDOCAINE HCI (HF Acquisition Co LLC), LIDOCAINE HCI (HF Acquisition Co LLC), POINT OF CARE LM 2.5 (NuCare Pharmaceuticals), LIDOCAINE HCL (HF Acquisition Co LLC), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), LIDOCAINE HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), LIDOCAINE HYDROCHLORIDE (Afaxys Pharma LLC), LIDOCAINE (Akorn), LIDOCAINE HYDROCHLORIDE (Akorn), LIDOCAINE HYDROCHLORIDE (Asclemed USA), LIDOCAINE HYDROCHLORIDE (Asclemed USA), LIDOCAINE HYDROCHLORIDE (Asclemed USA), LIDOCAINE HYDROCHLORIDE (Asclemed USA), LIDOCAINE HYDROCHLORIDE (AuroMedics Pharma LLC), LIDOCAINE HYDROCHLORIDE (AuroMedics Pharma LLC), LIDOCAINE HYDROCHLORIDE (AuroMedics Pharma LLC), LIDOCAINE HYDROCHLORIDE (B. Braun Medical), LIDOCAINE HYDROCHLORIDE (Bryant Ranch Prepack), LIDOCAINE HYDROCHLORIDE (Bryant Ranch Prepack), LIDOCAINE HYDROCHLORIDE (Camber Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Camber Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE VISCOUS (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Cardinal Health), LIDOCAINE HYDROCHLORIDE (Civica), LIDOCAINE HYDROCHLORIDE (DIRECT RX), LIDOCAINE HYDROCHLORIDE (DIRECT RX), LIDOCAINE (Fresenius Kabi USA), LIDOCAINE (Fresenius Kabi USA), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (General Injectables & Vaccines), LIDOCAINE HYDROCHLORIDE (HF Acquisition Co LLC), LIDOCAINE HYDROCHLORIDE (HF Acquisition Co LLC), LIDOCAINE HYDROCHLORIDE (Henry Schein), LIDOCAINE HYDROCHLORIDE (Henry Schein), LIDOCAINE HYDROCHLORIDE (Henry Schein), LIDOCAINE HYDROCHLORIDE (Henry Schein), LIDOCAINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), LIDOCAINE (Hikma Pharmaceuticals USA), LIDOCAINE HYDROCHLORIDE (Hospira), LIDOCAINE HYDROCHLORIDE (Huons), DX1 ORAGENOMIC MEDICATED DNA COLLECTION SCREEN (IT3 Medical LLC), SX1 MEDICATED POST-OPERATIVE SYSTEM (IT3 Medical LLC), VENIPUNCTURE PX1 (IT3 Medical LLC), DX2 ORAGENOMIC MEDICATED DNA COLLECTION SCREEN (IT3 Medical LLC), LIDOCAINE HYDROCHLORIDE (International Medication Systems), LIDOCAINE HYDROCHLORIDE (International Medication Systems), LIDOCAINE HYDROCHLORIDE (International Medication Systems), LIDOCAINE HYDROCHLORIDE (Lannett Company), LIDOCAINE HYDROCHLORIDE (Lannett Company), LIDOCAINE HYDROCHLORIDE (Marlex Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (McKesson Corporation), LIDOCAINE HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE (Medical Purchasing Solutions), LIDOCAINE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (NorthStar RxLLC), LIDOCAINE HYDROCHLORIDE (Novitium Pharma LLC), LIDOCAINE HYDROCHLORIDE (NuCare Pharmaceuticals), MEDICATED BUCCAL DNA COLLECTION KIT (NuCare Pharmaceuticals), MEDICATED BUCCAL DNA COLLECTION KIT 2 (NuCare Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (PINNACLE PHARMA LLC), LIDOCAINE VISCOUS (Pharmaceutical Associates), LIDOCAINE HYDROCHLORIDE (Preferred Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (RPK Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (RPK Pharmaceuticals), GLYDO (Sagent Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Teligent Pharma), LIDOCAINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp), LIDOCAINE VISCOUS (West-Ward Pharmaceuticals Corp.), LIDOCAINE HYDROCHLORIDE (Henry Schein), LIDOCAINE HYDROCHLORIDE (Spectra Medical Devices), POINT OF CARE LM 2.2 (NuCare Pharmaceuticals)

Formula

C14H22N2O. HCl

Exact mass

270.1499

Mol weight

270.7982

Structure

Simcomp

Class

Cardiovascular agent
DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01651  Class Ib antiarrhythmic agent
Neuropsychiatric agent
DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01673  Amide type local anesthetic
Metabolizing enzyme substrate
DG01892  CYP1A2 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Therapeutic category:

1214 1313 2129

ATC code:

C01BB01 C05AD01 D04AB01 N01BB02 R02AD02 S01HA07 S02DA01

Chemical structure group:

DG00196

Product (DG00196):

D00358<JP/US> D02086<JP/US> D08127<JP/US>

Product (mixture):

D04052<JP/US> D04813<JP/US>

Efficacy

Anesthetic (local), Antiarrhythmic, Sodium channel blocker

Comment

Anilide derivative

Target

SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]

Pathway

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04728

Dopaminergic synapse

Metabolism

Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576]

Interaction

Structure map

map07037

Antiarrhythmic drugs

map07231

Sodium channel blocking drugs

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB01 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD01 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB01 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB02 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD02 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA07 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
  S02 OTOLOGICALS
   S02D OTHER OTOLOGICALS
    S02DA Analgesics and anesthetics
     S02DA01 Lidocaine
      D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Anesthetics
  Local Anesthetics
   Lidocaine
    D02086  Lidocaine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D02086  Lidocaine hydrochloride (JAN/USP)
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1313  Ophthalmic local anesthetics
     D02086  Lidocaine hydrochloride (JAN/USP)
2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D02086  Lidocaine hydrochloride (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D02086  Lidocaine hydrochloride (JAN/USP)
Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D02086  Lidocaine hydrochloride (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
  Inorganic and organic chemicals
   Lidocaine
    D02086  Lidocaine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01651  Class Ib antiarrhythmic agent
     DG00196  Lidocaine
      D02086  Lidocaine hydrochloride
Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01673  Amide type local anesthetic
     DG00196  Lidocaine
      D02086  Lidocaine hydrochloride
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00196  Lidocaine
    D02086  Lidocaine hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00196  Lidocaine
     D02086  Lidocaine hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
  DG01653  Antiarrhythmics
   D02086  Lidocaine hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN2A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN3A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN4A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN5A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN8A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN9A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN10A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
    SCN11A
     D02086  Lidocaine hydrochloride (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D02086
Drug groups [BR:br08330]
Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01651  Class Ib antiarrhythmic agent
     DG00196  Lidocaine
Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01673  Amide type local anesthetic
     DG00196  Lidocaine
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00196  Lidocaine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00196  Lidocaine

Other DBs

CAS:

73-78-9

PubChem:

7849147

ChEBI:

50512

LigandBox:

D02086

NIKKAJI:

J231.458D J5.631F

KCF data

ATOM        18
            1   C8y C    27.4132  -17.1509
            2   N1b N    28.6465  -17.8641
            3   C8y C    26.1855  -17.8699
            4   C8y C    27.4132  -15.7304
            5   C5a C    29.8742  -17.1450
            6   C8x C    24.9579  -17.1509
            7   C1a C    26.1914  -19.2846
            8   C8x C    26.1855  -15.0230
            9   C1a C    28.6348  -15.0230
            10  C1b C    31.1017  -17.8641
            11  O5a O    29.9091  -16.0694
            12  C8x C    24.9579  -15.7304
            13  N1c N    32.3352  -17.1450
            14  C1b C    33.5686  -17.8641
            15  C1b C    32.3352  -15.7304
            16  C1a C    34.7845  -17.1450
            17  C1a C    33.5686  -15.0172
            18  X   Cl   39.1297  -16.5898
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17    8  12 1