Clindamycin hydrochloride


Entry
D02132                      Drug                                   
Name
Clindamycin hydrochloride (JP18/USP);
Cleocin hydrochloride (TN);
Dalacin (TN)
Product
CLEOCIN HYDROCHLORIDE (Pharmacia & Upjohn Company LLC), CLEOCIN HYDROCHLORIDE (RedPharm Drug)
  Generic
CLINDAMYCIN HCL (Advanced Rx Pharmacy of Tennessee), CLINDAMYCIN HCL (Advanced Rx Pharmacy of Tennessee), CLINDAMYCIN HYDROCHLORIDE (A-S Medication Solutions), CLINDAMYCIN HYDROCHLORIDE (A-S Medication Solutions), CLINDAMYCIN HYDROCHLORIDE (A-S Medication Solutions), CLINDAMYCIN HYDROCHLORIDE (A-S Medication Solutions), CLINDAMYCIN HYDROCHLORIDE (A-S Medication Solutions), CLINDAMYCIN HYDROCHLORIDE (A-S Medication Solutions), CLINDAMYCIN HYDROCHLORIDE (A-S Medication Solutions), CLINDAMYCIN HYDROCHLORIDE (A-S Medication Solutions), CLINDAMYCIN HYDROCHLORIDE (American Health Packaging), CLINDAMYCIN HYDROCHLORIDE (Amneal Pharmaceuticals NY LLC), CLINDAMYCIN HYDROCHLORIDE (Asclemed USA), CLINDAMYCIN HYDROCHLORIDE (Aurobindo Pharma Limited), CLINDAMYCIN HYDROCHLORIDE (AvPAK), CLINDAMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), CLINDAMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), CLINDAMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), CLINDAMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), CLINDAMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), CLINDAMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), CLINDAMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), CLINDAMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), CLINDAMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), CLINDAMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), CLINDAMYCIN HYDROCHLORIDE (Cadila Healthcare Limited), CLINDAMYCIN HYDROCHLORIDE (Cardinal Health), CLINDAMYCIN HYDROCHLORIDE (Cardinal Health), CLINDAMYCIN HYDROCHLORIDE (Clinical Solutions Wholesale), CLINDAMYCIN HYDROCHLORIDE (Cosette Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (DIRECT RX), CLINDAMYCIN HYDROCHLORIDE (DIRECT RX), CLINDAMYCIN HYDROCHLORIDE (DIRECT RX), CLINDAMYCIN HYDROCHLORIDE (DIRECT RX), CLINDAMYCIN HYDROCHLORIDE (Denton Pharma), CLINDAMYCIN HYDROCHLORIDE (Denton Pharma), CLINDAMYCIN HYDROCHLORIDE (Denton Pharma), CLINDAMYCIN HYDROCHLORIDE (Denton Pharma), CLINDAMYCIN HYDROCHLORIDE (Denton Pharma), CLINDAMYCIN HYDROCHLORIDE (Denton Pharma), CLINDAMYCIN HYDROCHLORIDE (Denton Pharma), CLINDAMYCIN HYDROCHLORIDE (Denton Pharma), CLINDAMYCIN HYDROCHLORIDE (Direct Rx), CLINDAMYCIN HYDROCHLORIDE (Golden State Medical Supply), CLINDAMYCIN HYDROCHLORIDE (Greenstone LLC), CLINDAMYCIN HYDROCHLORIDE (Lannett Company), CLINDAMYCIN HYDROCHLORIDE (Major Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (Major Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (McKesson Corporation dba Sky Packaging), CLINDAMYCIN HYDROCHLORIDE (Micro Labs Limited), CLINDAMYCIN HYDROCHLORIDE (NuCare Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (NuCare Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (NuCare Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (NuCare Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (NuCare Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (NuCare Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (NuCare Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (NuCare Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (NuCare Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (NuCare Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (NuCare Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (NuCare Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (NuCare Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (Preferred Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (Preferred Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (Preferred Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (Proficient Rx LP), CLINDAMYCIN HYDROCHLORIDE (Proficient Rx LP), CLINDAMYCIN HYDROCHLORIDE (Proficient Rx LP), CLINDAMYCIN HYDROCHLORIDE (Proficient Rx LP), CLINDAMYCIN HYDROCHLORIDE (Proficient Rx LP), CLINDAMYCIN HYDROCHLORIDE (Proficient Rx LP), CLINDAMYCIN HYDROCHLORIDE (Quality Care Products), CLINDAMYCIN HYDROCHLORIDE (REMEDYREPACK), CLINDAMYCIN HYDROCHLORIDE (REMEDYREPACK), CLINDAMYCIN HYDROCHLORIDE (REMEDYREPACK), CLINDAMYCIN HYDROCHLORIDE (RPK Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (RPK Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (RPK Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (RPK Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (RPK Pharmaceuticals), CLINDAMYCIN HYDROCHLORIDE (RedPharm Drug), CLINDAMYCIN HYDROCHLORIDE (RedPharm Drug), CLINDAMYCIN HYDROCHLORIDE (RedPharm Drug), CLINDAMYCIN HYDROCHLORIDE (RedPharm Drug), CLINDAMYCIN HYDROCHLORIDE (RedPharm Drug), CLINDAMYCIN HYDROCHLORIDE (RedPharm Drug), CLINDAMYCIN HYDROCHLORIDE (St Mary's Medical Park Pharmacy), CLINDAMYCIN HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), CLINDAMYCIN HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), CLINDAMYCIN HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), CLINDAMYCIN HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), CLINDAMYCIN HYDROCHLORIDE (Sun Pharmaceutical Industries), CLINDAMYCIN HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C18H33ClN2O5S. HCl
Exact mass
460.1565
Mol weight
461.444
Structure
Simcomp
Class
Antibacterial
 DG01578  Lincosamide antibiotic
Remark
Same as: C13684
Therapeutic category: 6112
ATC code: D10AF01 G01AA10 J01FF01
Chemical structure group: DG00435
Product (DG00435): D01073<JP/US> D01990<US> D02132<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Infections due to susceptible strains of streptococci [DS:H00333]
Infections due to susceptible strains of staphylococci [DS:H01175]
Comment
Semisynthetic lincosamide
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF01 Clindamycin
      D02132  Clindamycin hydrochloride (JP18/USP) <JP/US>
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA10 Clindamycin
      D02132  Clindamycin hydrochloride (JP18/USP) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FF Lincosamides
     J01FF01 Clindamycin
      D02132  Clindamycin hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Clindamycin
    D02132  Clindamycin hydrochloride (JP18/USP)
 Dermatological Agents
  Topical Anti-infectives
   Antibacterials, dermatological
    Clindamycin
     D02132  Clindamycin hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   611  Acting mainly on gram-positive bacteria
    6112  Lincomycins
     D02132  Clindamycin hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01578  Lincosamide antibiotic
   DG00435  Clindamycin
    D02132  Clindamycin hydrochloride
Drug classes [BR:br08332]
 Antibacterial
  DG01578  Lincosamide antibiotic
   D02132  Clindamycin hydrochloride
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Lincosamide
    D02132  Clindamycin hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02132  Clindamycin hydrochloride
  D02132  Clindamycin hydrochloride capsules
Drug groups [BR:br08330]
 Antibacterial
  DG01578  Lincosamide antibiotic
   DG00435  Clindamycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Lincosamide
    DG00435  Clindamycin
Prodrugs [br08324.html]
 DG00435
Other DBs
CAS: 21462-39-5
PubChem: 7849193
ChEBI: 176915 3745
LigandBox: D02132
NIKKAJI: J388.860F
KCF data

ATOM        28
            1   C1y C    21.6107  -15.6792
            2   C1y C    21.6107  -17.0811
            3   C1y C    22.8257  -17.7820
            4   C1y C    24.0407  -17.0811
            5   C1y C    24.0407  -15.6792
            6   O2x O    22.8257  -14.9783
            7   S2a S    25.2556  -14.9783
            8   C1a C    25.2556  -13.5765
            9   O1a O    25.2556  -17.7820
            10  O1a O    22.8257  -19.1840
            11  O1a O    20.3958  -17.7820
            12  C1c C    20.3958  -14.9783
            13  N1b N    19.1808  -15.6792
            14  C1c C    20.3958  -13.5765
            15  X   Cl   19.1808  -12.8755
            16  C1a C    21.6107  -12.8755
            17  C5a C    17.9659  -14.9783
            18  C1y C    16.7509  -15.6792
            19  O5a O    17.9659  -13.5765
            20  N1y N    15.6247  -14.8842
            21  C1x C    14.5053  -15.7071
            22  C1y C    14.9522  -17.0367
            23  C1x C    16.3361  -17.0298
            24  C1a C    15.6247  -13.4842
            25  C1b C    14.2583  -18.2527
            26  C1b C    12.8802  -18.2598
            27  C1a C    12.1821  -19.4837
            28  X   Cl   12.0400  -15.5400
BOND        28
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     5   7 1 #Down
            8     7   8 1
            9     4   9 1 #Down
            10    3  10 1 #Up
            11    2  11 1 #Up
            12    1  12 1
            13   12  13 1
            14   12  14 1
            15   14  15 1 #Up
            16   14  16 1
            17   13  17 1
            18   18  17 1 #Down
            19   17  19 2
            20   18  20 1
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24   18  23 1
            25   20  24 1
            26   22  25 1 #Up
            27   25  26 1
            28   26  27 1