Dibucaine hydrochloride


Entry
D02220                      Drug                                   
Name
Dibucaine hydrochloride (JP18/USP);
Nupercaine hydrochloride (TN);
Percamin (TN)
Formula
C20H29N3O2. HCl
Exact mass
379.2027
Mol weight
379.9241
Structure
Simcomp
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01673  Amide type local anesthetic
Remark
ATC code: C05AD04 D04AB02 N01BB06 S01HA06 S02DA04
Chemical structure group: DG00297
Product (mixture): D04022<JP> D04699<JP> D04816<JP> D04844<JP>
Efficacy
Anesthetic (local)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD04 Cinchocaine
      D02220  Dibucaine hydrochloride (JP18/USP)
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB02 Cinchocaine
      D02220  Dibucaine hydrochloride (JP18/USP)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB06 Cinchocaine
      D02220  Dibucaine hydrochloride (JP18/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA06 Cinchocaine
      D02220  Dibucaine hydrochloride (JP18/USP)
  S02 OTOLOGICALS
   S02D OTHER OTOLOGICALS
    S02DA Analgesics and anesthetics
     S02DA04 Cinchocaine
      D02220  Dibucaine hydrochloride (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D02220  Dibucaine hydrochloride (JP18/USP)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D02220  Dibucaine hydrochloride (JP18/USP)
   D02220  Dibucaine hydrochloride (JP18/USP)
 Agents for dental and stomatological use
  75 Toothache and pyorrhea remedies
   D02220  Dibucaine hydrochloride (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Dibucaine
    D02220  Dibucaine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01673  Amide type local anesthetic
     DG00297  Dibucaine
      D02220  Dibucaine hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D02220  Dibucaine hydrochloride (JP18/USP)
    SCN2A
     D02220  Dibucaine hydrochloride (JP18/USP)
    SCN3A
     D02220  Dibucaine hydrochloride (JP18/USP)
    SCN4A
     D02220  Dibucaine hydrochloride (JP18/USP)
    SCN5A
     D02220  Dibucaine hydrochloride (JP18/USP)
    SCN8A
     D02220  Dibucaine hydrochloride (JP18/USP)
    SCN9A
     D02220  Dibucaine hydrochloride (JP18/USP)
    SCN10A
     D02220  Dibucaine hydrochloride (JP18/USP)
    SCN11A
     D02220  Dibucaine hydrochloride (JP18/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02220  Dibucaine hydrochloride
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01673  Amide type local anesthetic
     DG00297  Dibucaine
Other DBs
CAS: 61-12-1
PubChem: 7849279
ChEBI: 59735
LigandBox: D02220
NIKKAJI: J98.202D
KCF data

ATOM        26
            1   C8x C    22.7901  -15.3180
            2   C8x C    22.7901  -16.7282
            3   C8x C    24.0113  -17.4333
            4   C8y C    25.2326  -16.7282
            5   C8y C    25.2326  -15.3180
            6   C8x C    24.0113  -14.6130
            7   N5x N    26.4538  -17.4333
            8   C8y C    27.6750  -16.7282
            9   C8x C    27.6750  -15.3180
            10  C8y C    26.4538  -14.6130
            11  O2a O    28.8813  -17.4247
            12  C5a C    26.4538  -13.2028
            13  N1b N    27.6772  -12.4965
            14  C1b C    28.8823  -13.1925
            15  C1b C    30.0778  -12.5023
            16  N1c N    31.2779  -13.1955
            17  O5a O    25.2347  -12.4989
            18  C1b C    32.4759  -12.5039
            19  C1b C    31.2779  -14.6127
            20  C1a C    32.4790  -15.3064
            21  C1a C    33.6748  -13.1962
            22  C1b C    30.0783  -16.7337
            23  C1b C    31.2777  -17.4263
            24  C1b C    32.4759  -16.7345
            25  C1a C    33.6747  -17.4267
            26  X   Cl   36.8900  -15.3300
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    8  11 1
            13   10  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   12  17 2
            19   16  18 1
            20   16  19 1
            21   19  20 1
            22   18  21 1
            23   11  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1