Paroxetine hydrochloride hemihydrate


Entry
D02260                      Drug                                   
Name
Paroxetine hydrochloride hemihydrate (USP);
Paroxetine hydrochloride hydrate (JP18);
Paxil (TN)
Product
PAROXETINE HYDROCHLORIDE (Apotex Corp), PAXIL (Apotex Corp), PAXIL (Apotex Corp), PAXIL (Apotex Corp), PAROXETINE HYDROCHLORIDE (Bryant Ranch Prepack)
  Generic
PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aurolife Pharma LLC), PAROXETINE (AvPAK), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Cadila Pharmaceuticals Limited), PAROXETINE (Clinical Solutions Wholesale), PAROXETINE (Lupin Pharmaceuticals), PAROXETINE (McKesson Corporation dba SKY Packaging), PAROXETINE (Modavar Pharmaceuticals LLC), PAROXETINE (NCS HealthCare of KY), PAROXETINE (Northwind Pharmaceuticals), PAROXETINE (Novitium Pharma LLC), PAROXETINE (NuCare Pharmaceuticals), PAROXETINE (NuCare Pharmaceuticals), PAROXETINE (NuCare Pharmaceuticals), PAROXETINE (NuCare Pharmaceuticals), PAROXETINE (NuCare Pharmaceuticals), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE (Proficient Rx LP), PAROXETINE (Proficient Rx LP), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (St. Mary's Medical Park Pharmacy), PAROXETINE (St. Mary's Medical Park Pharmacy), PAROXETINE (Yiling Pharmaceutical), PAROXETINE (Zydus Pharmaceuticals (USA)), PAROXETINE (American Health Packaging), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aurobindo Pharma Limited), PAROXETINE HYDROCHLORIDE (Bryant Ranch Prepack), PAROXETINE (Cadila Healthcare Limited), PAROXETINE (Lake Erie Medical DBA Quality Care Products LLC), PAROXETINE (NorthStar Rx LLC), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE HYDROCHLORIDE (REMEDYREPACK), PAROXETINE (A-S Medication Solutions), PAROXETINE (A-S Medication Solutions), PAROXETINE (A-S Medication Solutions), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Denton Pharma), PAROXETINE (Lake Erie Medical DBA Quality Care Products LLC), PAROXETINE (Lake Erie Medical DBA Quality Care Products LLC), PAROXETINE (Mylan Pharmaceuticals), PAROXETINE (NCS HealthCare of KY), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE (Proficient Rx LP), PAROXETINE (Proficient Rx LP), PAROXETINE (Proficient Rx LP), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (RPK Pharmaceuticals), PAROXETINE (Rhodes Pharmaceuticals L.P.), PAROXETINE (Solco Healthcare US)
Formula
(C19H20FNO3. HCl)2. H2O
Exact mass
748.2494
Mol weight
749.668
Structure
Class
Neuropsychiatric agent
 DG01659  Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 1179
ATC code: N06AB05
Chemical structure group: DG00944
Product (DG00944): D02260<JP/US> D05374<US> D05375<US>
Efficacy
Antidepressant, Selective serotonin reuptake inhibitor (SSRI)
  Disease
Major depressive disorder [DS:H01646]
Panic disorder [DS:H01664]
Social anxiety disorder [DS:H01670]
Comment
Fluoxetine derivative
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB05 Paroxetine
      D02260  Paroxetine hydrochloride hemihydrate (USP) <JP/US>
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D02260  Paroxetine hydrochloride hemihydrate (USP)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D02260  Paroxetine hydrochloride hemihydrate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D02260  Paroxetine hydrochloride hemihydrate (USP); Paroxetine hydrochloride hydrate (JP18)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   DG00944  Paroxetine
    D02260  Paroxetine hydrochloride hemihydrate
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00944  Paroxetine
    D02260  Paroxetine hydrochloride hemihydrate
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00944  Paroxetine
    D02260  Paroxetine hydrochloride hemihydrate
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   D02260  Paroxetine hydrochloride hemihydrate
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D02260  Paroxetine hydrochloride hemihydrate (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02260  Paroxetine hydrochloride hydrate
  D02260  Paroxetine hydrochloride tablets
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02260
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02260
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D02260
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   DG00944  Paroxetine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00944  Paroxetine
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00944  Paroxetine
Other DBs
PubChem: 7849319
LigandBox: D02260
KCF data

ATOM        51
            1   O0  O    41.1566  -17.6442
            2   C1y C    33.8100  -18.5500
            3   C1y C    32.5500  -19.2500
            4   C8y C    33.8100  -17.1500
            5   C1x C    35.0000  -19.2500
            6   C1b C    31.3600  -18.5500
            7   C1x C    32.5500  -20.6500
            8   C8x C    35.0000  -16.4500
            9   C8x C    32.5500  -16.4500
            10  C1x C    35.0000  -20.6500
            11  O2a O    30.1700  -19.2500
            12  N1x N    33.8100  -21.3500
            13  C8x C    35.0000  -15.0500
            14  C8x C    32.5500  -15.0500
            15  C8y C    28.9100  -18.5500
            16  C8y C    33.8100  -14.3500
            17  C8x C    28.9100  -17.1500
            18  C8x C    27.7200  -19.2500
            19  X   F    33.8100  -12.9500
            20  C8y C    27.7200  -16.4500
            21  C8x C    26.5300  -18.5500
            22  C8y C    26.5300  -17.1500
            23  O2x O    27.4400  -15.1200
            24  O2x O    25.4800  -16.2400
            25  C1x C    26.0400  -14.9100
            26  X   Cl   37.7300  -17.5700
            27  C1y C    33.8100  -18.5500
            28  C1y C    32.5500  -19.2500
            29  C1b C    31.3600  -18.5500
            30  O2a O    30.1700  -19.2500
            31  C8y C    28.9100  -18.5500
            32  C8x C    28.9100  -17.1500
            33  C8y C    27.7200  -16.4500
            34  C8y C    26.5300  -17.1500
            35  C8x C    26.5300  -18.5500
            36  C8x C    27.7200  -19.2500
            37  O2x O    25.4800  -16.2400
            38  C1x C    26.0400  -14.9100
            39  O2x O    27.4400  -15.1200
            40  C1x C    32.5500  -20.6500
            41  N1x N    33.8100  -21.3500
            42  C1x C    35.0000  -20.6500
            43  C1x C    35.0000  -19.2500
            44  C8y C    33.8100  -17.1500
            45  C8x C    35.0000  -16.4500
            46  C8x C    35.0000  -15.0500
            47  C8y C    33.8100  -14.3500
            48  C8x C    32.5500  -15.0500
            49  C8x C    32.5500  -16.4500
            50  X   F    33.8100  -12.9500
            51  X   Cl   37.7300  -17.5700
BOND        54
            1    14  16 1
            2    21  22 1
            3    24  25 1
            4     2   3 1
            5     2   4 1 #Down
            6     2   5 1
            7     3   6 1 #Up
            8     3   7 1
            9     4   8 2
            10    4   9 1
            11    5  10 1
            12    6  11 1
            13    7  12 1
            14    8  13 1
            15    9  14 2
            16   11  15 1
            17   13  16 2
            18   15  17 2
            19   15  18 1
            20   16  19 1
            21   17  20 1
            22   18  21 2
            23   20  22 2
            24   20  23 1
            25   22  24 1
            26   23  25 1
            27   10  12 1
            28   48  47 1
            29   35  34 1
            30   37  38 1
            31   27  28 1
            32   27  44 1 #Down
            33   27  43 1
            34   28  29 1 #Up
            35   28  40 1
            36   44  45 2
            37   44  49 1
            38   43  42 1
            39   29  30 1
            40   40  41 1
            41   45  46 1
            42   49  48 2
            43   30  31 1
            44   46  47 2
            45   31  32 2
            46   31  36 1
            47   47  50 1
            48   32  33 1
            49   36  35 2
            50   33  34 2
            51   33  39 1
            52   34  37 1
            53   39  38 1
            54   42  41 1
BRACKET     1    25.0600  -22.8200   25.0600  -12.2500
            1    38.5000  -12.2500   38.5000  -22.8200
            1  2
 ORIGINAL  1    2   3   6  11  15  17  20  22  21  18  24  25  23   7  12  10
            1    5   4   8  13  16  14   9  19  26
 REPEAT    1   27  28  29  30  31  32  33  34  35  36  37  38  39  40  41  42
            1   43  44  45  46  47  48  49  50  51