Foscarnet sodium hydrate


Entry
D02267                      Drug                                   
Name
Foscarnet sodium hydrate (JAN);
Trisodium phosphonoformate hexahydrate;
Foscavir (TN)
Product
FOSCAVIR (Clinigen Limited), FOSCAVIR (Clinigen Limited), FOSCAVIR (Clinigen Limited)
  Generic
FOSCARNET (Fresenius Kabi USA), FOSCARNET SODIUM (Gland Pharma Limited), FOSCARNET SODIUM (Sagent Pharmaceuticals)
Formula
CO5P. 6H2O. 3Na
Exact mass
299.981
Mol weight
300.0424
Structure
Simcomp
Class
Antiviral
 DG01937  Anti-cytomegalovirus agent
Remark
Therapeutic category: 6250
ATC code: J05AD01
Chemical structure group: DG00651
Product (DG00651): D02267<JP/US>
Efficacy
Antiviral, DNA polymerase inhibitor
Comment
Phosphonic acid derivative
Target
HCMV DNA polymerase [KO:K18964]
  Pathway
ko03240  Viral replication
Interaction
Structure map
map07044  Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AD Phosphonic acid derivatives
     J05AD01 Foscarnet
      D02267  Foscarnet sodium hydrate (JAN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-cytomegalovirus (CMV) Agents
   Foscarnet
    D02267  Foscarnet sodium hydrate (JAN)
  Antiherpetic Agents
   Foscarnet
    D02267  Foscarnet sodium hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D02267  Foscarnet sodium hydrate (JAN)
Drug groups [BR:br08330]
 Antiviral
  DG01937  Anti-cytomegalovirus agent
   DG00651  Foscarnet
    D02267  Foscarnet sodium hydrate
Drug classes [BR:br08332]
 Antiviral
  DG01937  Anti-cytomegalovirus agent
   D02267  Foscarnet sodium hydrate
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   Herpesvirus DNA polymerase inhibitor
    D02267  Foscarnet sodium hydrate (JAN) <JP/US>
Drug groups [BR:br08330]
 Antiviral
  DG01937  Anti-cytomegalovirus agent
   DG00651  Foscarnet
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Genome replication inhibitor
   Herpesvirus DNA polymerase inhibitor
    DG00651  Foscarnet
Other DBs
CAS: 34156-56-4
PubChem: 7849326
ChEBI: 60269
LigandBox: D02267
NIKKAJI: J2.215.056A
KCF data

ATOM        16
            1   O0  O    35.4900  -21.2800
            2   Z   Na   26.7400  -23.1000 #+
            3   Z   Na   31.0100  -21.8400 #+
            4   Z   Na   24.1500  -20.5800 #+
            5   P1b P    27.3700  -20.5800
            6   C6a C    28.7700  -20.5800
            7   O1c O    27.3700  -21.9800 #-
            8   O1c O    25.9700  -20.5800 #-
            9   O1c O    27.3700  -19.1800
            10  O6a O    29.4700  -21.8400 #-
            11  O6a O    29.4700  -19.3900
            12  O0  O    35.4900  -21.2800
            13  O0  O    35.4900  -21.2800
            14  O0  O    35.4900  -21.2800
            15  O0  O    35.4900  -21.2800
            16  O0  O    35.4900  -21.2800
BOND        6
            1     5   7 1
            2     5   8 1
            3     5   9 2
            4     6  10 1
            5     5   6 1
            6     6  11 2
BRACKET     1    33.4600  -22.1200   33.4600  -20.4400
            1    35.9800  -20.4400   35.9800  -22.1200
            1  6
 ORIGINAL  1    1
 REPEAT    1   12  13  14  15  16