| Entry |
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|---|---|---|---|---|---|---|---|---|---|
| Name | Hydrocortisone valerate (USP); Westcort (TN) | ||||||||
| Product | |||||||||
| Generic | HYDROCORTISONE VALERATE (Cosette Pharmaceuticals), HYDROCORTISONE VALERATE (Cosette Pharmaceuticals), HYDROCORTISONE VALERATE (DIRECT RX), HYDROCORTISONE VALERATE (Glenamrk Pharmaceuticals), HYDROCORTISONE VALERATE (Glenmark Pharmaceuticals), HYDROCORTISONE VALERATE (Lupin Pharmaceuticals), HYDROCORTISONE VALERATE (Padagis Israel Pharmaceuticals), HYDROCORTISONE VALERATE (Taro Pharmaceuticals U.S.A.), HYDROCORTISONE VALERATE CREAM (Encube Ethicals Private Limited) | ||||||||
| Formula | C26H38O6 | ||||||||
| Exact mass | 446.2668 | ||||||||
| Mol weight | 446.5763 | ||||||||
| Structure |  | ||||||||
| Simcomp | |||||||||
| Class | Anti-inflammatory DG01955 Corticosteroid DG02068 Glucocorticoid Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate | ||||||||
| Remark |
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| Efficacy | Anti-inflammatory, Glucocorticoid receptor agonist | ||||||||
| Target | NR3C1 (GR) [HSA:2908] [KO:K05771] | ||||||||
| Pathway |
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| Metabolism | Enzyme: CYP3A [HSA:1576 1577 1551] | ||||||||
| Interaction | |||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] A ALIMENTARY TRACT AND METABOLISM A01 STOMATOLOGICAL PREPARATIONS A01A STOMATOLOGICAL PREPARATIONS A01AC Corticosteroids for local oral treatment A01AC03 Hydrocortisone D02288 Hydrocortisone valerate (USP) <US> A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS A07E INTESTINAL ANTIINFLAMMATORY AGENTS A07EA Corticosteroids acting locally A07EA02 Hydrocortisone D02288 Hydrocortisone valerate (USP) <US> C CARDIOVASCULAR SYSTEM C05 VASOPROTECTIVES C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE C05AA Corticosteroids C05AA01 Hydrocortisone D02288 Hydrocortisone valerate (USP) <US> D DERMATOLOGICALS D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS D07A CORTICOSTEROIDS, PLAIN D07AA Corticosteroids, weak (group I) D07AA02 Hydrocortisone D02288 Hydrocortisone valerate (USP) <US> D07X CORTICOSTEROIDS, OTHER COMBINATIONS D07XA Corticosteroids, weak, other combinations D07XA01 Hydrocortisone D02288 Hydrocortisone valerate (USP) <US> H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS H02 CORTICOSTEROIDS FOR SYSTEMIC USE H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN H02AB Glucocorticoids H02AB09 Hydrocortisone D02288 Hydrocortisone valerate (USP) <US> S SENSORY ORGANS S01 OPHTHALMOLOGICALS S01B ANTIINFLAMMATORY AGENTS S01BA Corticosteroids, plain S01BA02 Hydrocortisone D02288 Hydrocortisone valerate (USP) <US> S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION S01CB Corticosteroids/antiinfectives/mydriatics in combination S01CB03 Hydrocortisone D02288 Hydrocortisone valerate (USP) <US> S02 OTOLOGICALS S02B CORTICOSTEROIDS S02BA Corticosteroids S02BA01 Hydrocortisone D02288 Hydrocortisone valerate (USP) <US> USP drug classification [BR:br08302] Dermatological Agents Dermatitis and Pruitus Agents Glucocorticoids, Low Potency Hydrocortisone D02288 Hydrocortisone valerate (USP) Glucocorticoids, Medium Potency Hydrocortisone D02288 Hydrocortisone valerate (USP) Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal) Hydrocortisone D02288 Hydrocortisone valerate (USP) Inflammatory Bowel Disease Agents Glucocorticoids Hydrocortisone D02288 Hydrocortisone valerate (USP) Drug groups [BR:br08330] Anti-inflammatory DG01955 Corticosteroid DG02068 Glucocorticoid DG00012 Hydrocortisone D02288 Hydrocortisone valerate Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG00012 Hydrocortisone D02288 Hydrocortisone valerate Drug classes [BR:br08332] Anti-inflammatory DG01955 Corticosteroid D02288 Hydrocortisone valerate Target-based classification of drugs [BR:br08310] Nuclear receptors Estrogen like receptors 3-Ketosteroid receptor NR3C1 (GR) D02288 Hydrocortisone valerate (USP) <US> Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D02288 Topical steroids potency [br08317.html] Classification in the USA D02288 Drug groups [BR:br08330] Anti-inflammatory DG01955 Corticosteroid DG02068 Glucocorticoid DG00012 Hydrocortisone Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG00012 Hydrocortisone | ||||||||
| Other DBs |
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| KCF data | ATOM 32 1 C1y C 15.2600 -7.7700 2 C1y C 14.0700 -8.4700 3 C1z C 15.2600 -6.4400 4 C1x C 17.5700 -7.7700 5 C1y C 12.8800 -7.7700 6 C1x C 14.0700 -9.8000 7 C1z C 16.4500 -5.7400 8 C1x C 14.0700 -5.7400 9 C1a C 15.2600 -5.0400 10 C1x C 17.5700 -6.4400 11 C1z C 11.6900 -8.4700 12 C1y C 12.8800 -6.4400 13 C1x C 12.8800 -10.5000 14 C5a C 16.4500 -4.3400 15 C2y C 11.6900 -9.8000 16 C1x C 10.5000 -7.7700 17 C1a C 11.6900 -7.0700 18 O1a O 11.6900 -5.7400 19 C1b C 17.6400 -3.6400 20 O5a O 15.2600 -3.6400 21 C2x C 10.5000 -10.5000 22 C1x C 9.3100 -8.4700 23 O1a O 18.8300 -4.3400 24 C5x C 9.3100 -9.8000 25 O5x O 8.1200 -10.5000 26 O7a O 17.6745 -5.0613 27 C7a C 18.8397 -5.7615 28 C1b C 20.0658 -5.0820 29 C1b C 21.2960 -5.8210 30 C1b C 22.5127 -5.1462 31 C1a C 23.7480 -5.8876 32 O6a O 18.8155 -7.1399 BOND 35 1 1 2 1 2 1 3 1 3 1 4 1 4 2 5 1 5 2 6 1 6 3 7 1 7 3 8 1 8 3 9 1 #Up 9 4 10 1 10 5 11 1 11 5 12 1 12 6 13 1 13 7 14 1 #Up 14 11 15 1 15 11 16 1 16 11 17 1 #Up 17 12 18 1 #Up 18 14 19 1 19 14 20 2 20 15 21 2 21 16 22 1 22 19 23 1 23 21 24 1 24 24 25 2 25 7 10 1 26 8 12 1 27 13 15 1 28 22 24 1 29 7 26 1 #Down 30 26 27 1 31 27 28 1 32 28 29 1 33 29 30 1 34 30 31 1 35 27 32 2 |