Imiquimod

Entry

D02500                      Drug

Name

Imiquimod (JAN/USP/INN);
Aldara (TN);
Zyclara (TN)

Abbr

IQM

Product

ALDARA (Bausch Health US LLC), ZYCLARA (Bausch Health US), IMIQUIMOD (Oceanside Pharmacueticals)

Generic

IMIQUIMOD (Bryant Ranch Prepack), IMIQUIMOD (DIRECT RX), IMIQUIMOD (E. Fougera & Co. a division of Fougera Pharmaceuticals), IMIQUIMOD (Glenmark Pharmaceuticals), IMIQUIMOD (Padagis Israel Pharmaceuticals), IMIQUIMOD (Taro Pharmaceuticals U.S.A.), IMIQUIMOD (Taro Pharmaceuticals U.S.A.), IMIQUIMOD (Teva Pharmaceuticals USA)

Formula

C14H16N4

Exact mass

240.1375

Mol weight

240.3036

Structure

Simcomp

Remark

Therapeutic category:

6290

ATC code:

D06BB10

Product:

D02500<JP/US>

Efficacy

Antiviral, Immunomodulator, Toll-like receptor agonist

Disease

Actinic keratosis [DS:H02429]
Basal cell carcinoma [DS:H00029]
Genital warts [DS:H01418]

Target

TLR7 [HSA:51284] [KO:K05404]

Pathway

hsa04613

Neutrophil extracellular trap formation

hsa04620

Toll-like receptor signaling pathway

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06B CHEMOTHERAPEUTICS FOR TOPICAL USE
    D06BB Antivirals
     D06BB10 Imiquimod
      D02500  Imiquimod (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
  Dermatological Agents, Other
   Warts and Actinic Keratosis Agents
    Imiquimod
     D02500  Imiquimod (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   629  Miscellaneous
    6290  Miscellaneous
     D02500  Imiquimod (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
Cytokines and receptors
  Pattern recognition receptors
   Toll-like receptors
    TLR7
     D02500  Imiquimod (JAN/USP/INN) <JP/US>
Antimicrobials [BR:br08307]
Antivirals
  Genome replication inhibitor
   Other inhibitor
    D02500  Imiquimod (JAN/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
Antivirals
  Genome replication inhibitor
   Other inhibitor
    D02500  Imiquimod (JAN/USP/INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D02500
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D02500

Other DBs

CAS:	99011-02-6

PubChem:

17396674

PDB-CCD:

6T0[PDBj]

LigandBox:

D02500

NIKKAJI:

J501.447F

KCF data

ATOM        18
            1   C8y C    24.0293  -16.9272
            2   C8y C    24.0236  -15.5377
            3   N4y N    22.7098  -17.3632
            4   C8y C    25.2386  -17.6247
            5   N5x N    22.7039  -15.1133
            6   C8y C    25.2386  -14.8400
            7   C8x C    21.8842  -16.2353
            8   C1b C    22.6922  -18.9793
            9   C8y C    26.4361  -16.9272
            10  N5x N    26.4361  -15.5377
            11  N1a N    25.2386  -13.4506
            12  C1c C    21.5761  -19.6886
            13  C1a C    20.4482  -18.9851
            14  C1a C    21.5819  -21.0799
            15  C8x C    25.2422  -18.9858
            16  C8x C    27.6759  -17.6394
            17  C8x C    27.6796  -19.0554
            18  C8x C    26.4964  -19.7428
BOND        20
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    6  11 1
            11    8  12 1
            12   12  13 1
            13    5   7 2
            14    9  10 2
            15   12  14 1
            16    4  15 1
            17    9  16 1
            18   16  17 2
            19   17  18 1
            20   18  15 2