Entry

D02624                      Drug

Name

Eszopiclone (JAN/USP/INN);
Estorra (TN);
Lunesta (TN)

Product

LUNESTA (Sunovion Pharmaceuticals)

Generic

ESZOPICLONE (A-S Medication Solutions), ESZOPICLONE (A-S Medication Solutions), ESZOPICLONE (A-S Medication Solutions), ESZOPICLONE (A-S Medication Solutions), ESZOPICLONE (A-S Medication Solutions), ESZOPICLONE (Advanced Rx Pharmacy of Tennessee), ESZOPICLONE (Advanced Rx Pharmacy of Tennessee), ESZOPICLONE (Advanced Rx Pharmacy of Tennessee), ESZOPICLONE (Advanced Rx Pharmacy of Tennessee), ESZOPICLONE (Advanced Rx Pharmacy of Tennessee), ESZOPICLONE (Advanced Rx Pharmacy of Tennessee), ESZOPICLONE (Advanced Rx Pharmacy of Tennessee), ESZOPICLONE (Advanced Rx Pharmacy of Tennessee), ESZOPICLONE (Advanced Rx Pharmacy of Tennessee), ESZOPICLONE (Aphena Pharma Solutions - Tennessee), ESZOPICLONE (Aphena Pharma Solutions - Tennessee), ESZOPICLONE (Aphena Pharma Solutions - Tennessee), ESZOPICLONE (Asclemed USA), ESZOPICLONE (Aurobindo Pharma Limited), ESZOPICLONE (Bionpharma), ESZOPICLONE (Bryant Ranch Prepack), ESZOPICLONE (Bryant Ranch Prepack), ESZOPICLONE (Bryant Ranch Prepack), ESZOPICLONE (Bryant Ranch Prepack), ESZOPICLONE (Bryant Ranch Prepack), ESZOPICLONE (Bryant Ranch Prepack), ESZOPICLONE (Bryant Ranch Prepack), ESZOPICLONE (Bryant Ranch Prepack), ESZOPICLONE (DIRECT RX), ESZOPICLONE (DIRECT RX), ESZOPICLONE (DIRECT RX), ESZOPICLONE (DIRECT RX), ESZOPICLONE (DIRECT RX), ESZOPICLONE (DIRECT RX), ESZOPICLONE (DIRECT RX), ESZOPICLONE (Direct Rx), ESZOPICLONE (DirectRX), ESZOPICLONE (Direct_Rx), ESZOPICLONE (Dr. Reddy's Laboratories Limited), ESZOPICLONE (Glenmark Pharmaceuticals Inc. USA), ESZOPICLONE (Golden State Medical Supply), ESZOPICLONE (Lake Erie Medical DBA Quality Care Products LLC), ESZOPICLONE (Lake Erie Medical DBA Quality Care Products LLC), ESZOPICLONE (Lupin Pharmaceuticals), ESZOPICLONE (Macleods Pharmaceuticals Limited), ESZOPICLONE (Medsource Pharmaceuticals), ESZOPICLONE (Mylan Pharmaceuticals), ESZOPICLONE (NuCare Pharmaceuticals), ESZOPICLONE (NuCarePharmaceuticals), ESZOPICLONE (OrchidPharma), ESZOPICLONE (PD-Rx Pharmaceuticals), ESZOPICLONE (PD-Rx Pharmaceuticals), ESZOPICLONE (Preferred Pharmaceuticals), ESZOPICLONE (Preferred Pharmaceuticals), ESZOPICLONE (Preferred Pharmaceuticals Inc. USA), ESZOPICLONE (Preferred Pharmaceuticals), ESZOPICLONE (Proficient Rx LP), ESZOPICLONE (Proficient Rx LP), ESZOPICLONE (Proficient Rx LP), ESZOPICLONE (Proficient Rx LP), ESZOPICLONE (Proficient Rx LP), ESZOPICLONE (Proficient Rx LP), ESZOPICLONE (Proficient Rx LP), ESZOPICLONE (Proficient Rx LP), ESZOPICLONE (Proficient Rx LP), ESZOPICLONE (Proficient Rx LP), ESZOPICLONE (Quality Care Products LLC), ESZOPICLONE (REMEDYREPACK), ESZOPICLONE (REMEDYREPACK), ESZOPICLONE (REMEDYREPACK), ESZOPICLONE (REMEDYREPACK), ESZOPICLONE (St Mary's Medical Park Phcy), ESZOPICLONE (St. Mary's Medical Park Pharmacy), ESZOPICLONE (St. Mary's Medical Park Pharmacy), ESZOPICLONE (Sun Pharmaceutical Industries), ESZOPICLONE (Teva Pharmaceuticals USA), ESZOPICLONE (Unit Dose Services)

Formula

C17H17ClN6O3

Exact mass

388.1051

Mol weight

388.8083

Structure

Simcomp

Class

Neuropsychiatric agent
DG01836  Non-benzodiazepine sedative-hypnotics
DG03202  Hypnotic
DG01567  GABA-A receptor agonist
Metabolizing enzyme substrate
DG02855  CYP2E1 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Therapeutic category:

1129

ATC code:

N05CF04

Product:

D02624<JP/US>

Efficacy

Sedative-hypnotic

Disease

Insomnia [DS:H01609]

Comment

See Zopiclone [DR:D01372]

Target

GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04727

GABAergic synapse

Metabolism

Enzyme: CYP3A4 [HSA:1576]; CYP2E1 [HSA:1571]

Interaction

Structure map

map07032

Hypnotics

map07230

GABA-A receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CF Benzodiazepine related drugs
     N05CF04 Eszopiclone
      D02624  Eszopiclone (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Sleep Disorder Agents
  Sleep Promoting Agents
   Eszopiclone
    D02624  Eszopiclone (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1129  Others
     D02624  Eszopiclone (JAN/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01836  Non-benzodiazepine sedative-hypnotics
   D02624  Eszopiclone
  DG03202  Hypnotic
   D02624  Eszopiclone
  DG01567  GABA-A receptor agonist
   D02624  Eszopiclone
Metabolizing enzyme substrate
  DG02855  CYP2E1 substrate
   D02624  Eszopiclone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D02624  Eszopiclone
Drug classes [BR:br08332]
Neuropsychiatric agent
  DG03202  Hypnotic
   D02624  Eszopiclone
Target-based classification of drugs [BR:br08310]
Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D02624  Eszopiclone (JAN/USP/INN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D02624
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D02624
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D02624
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D02624

Other DBs

CAS:	138729-47-2

PubChem:

17396794

ChEBI:

53760

LigandBox:

D02624

KCF data

ATOM        27
            1   C8x C    13.5800  -12.3200
            2   C8x C    13.5800  -13.7200
            3   N5x N    14.7700  -14.4200
            4   C8y C    16.0300  -13.7200
            5   C8y C    16.0300  -12.3200
            6   N5x N    14.7700  -11.6200
            7   C1y C    17.3600  -14.1400
            8   N1y N    18.2000  -13.0200
            9   C5x C    17.3600  -11.9000
            10  C8y C    19.5300  -13.0200
            11  N5x N    20.2300  -11.8300
            12  C8x C    21.6300  -11.8300
            13  C8y C    22.3300  -13.0200
            14  C8x C    21.6300  -14.2100
            15  C8x C    20.2300  -14.2100
            16  O5x O    17.7800  -10.5700
            17  X   Cl   23.7300  -13.0200
            18  O7a O    17.3600  -15.5400
            19  C7a C    18.5500  -16.2400
            20  N1y N    18.5500  -17.6400
            21  O6a O    19.8100  -15.5400
            22  C1x C    17.3600  -18.3400
            23  C1x C    17.3600  -19.7400
            24  N1y N    18.5500  -20.4400
            25  C1x C    19.8100  -19.7400
            26  C1x C    19.8100  -18.3400
            27  C1a C    18.5500  -21.8400
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12   10  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   10  15 1
            18    9  16 2
            19   13  17 1
            20   18  19 1
            21   19  20 1
            22   19  21 2
            23    7  18 1 #Up
            24   20  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   20  26 1
            30   24  27 1