| Entry |
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|---|---|---|---|---|---|---|---|---|---|
| Name | Alprostadil alfadex (JP18); Tandetron (TN); Caverject (TN) | ||||||||
| Formula | (C36H60O30)x. C20H34O5 | ||||||||
| Structure |  | ||||||||
| Simcomp | |||||||||
| Class | Hormonal agent DG01961 Prostaglandin derivative DG01611 Prostaglandin E1 derivative | ||||||||
| Remark |
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| Efficacy | Anti-ulcerative (skin), Vasodilator, Prostaglandin E1 receptor agonist | ||||||||
| Comment | Prostaglandin derivative alpha-Cyclodextrin inclusion agent | ||||||||
| Target | PTGER1 [HSA:5731] [KO:K04258] | ||||||||
| Pathway |
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| Interaction | |||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] C CARDIOVASCULAR SYSTEM C01 CARDIAC THERAPY C01E OTHER CARDIAC PREPARATIONS C01EA Prostaglandins C01EA01 Alprostadil D02705 Alprostadil alfadex (JP18) <JP> G GENITO URINARY SYSTEM AND SEX HORMONES G04 UROLOGICALS G04B UROLOGICALS G04BE Drugs used in erectile dysfunction G04BE01 Alprostadil D02705 Alprostadil alfadex (JP18) <JP> USP drug classification [BR:br08302] Hormonal Agents, Stimulant/Replacement/Modifying (Prostaglandins) Alprostadil D02705 Alprostadil alfadex (JP18) Sexual Disorder Agents Sexual Disorder Agents (Male) Alprostadil D02705 Alprostadil alfadex (JP18) Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 21 Cardiovascular agents 219 Miscellaneous 2190 Miscellaneous D02705 Alprostadil alfadex (JP18) 26 Epidermides 269 Miscellaneous 2699 Others D02705 Alprostadil alfadex (JP18) Drug groups [BR:br08330] Hormonal agent DG01961 Prostaglandin derivative DG01611 Prostaglandin E1 derivative DG00239 Alprostadil D02705 Alprostadil alfadex Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Prostaglandin PTGER1 D02705 Alprostadil alfadex (JP18) <JP> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D02705 Alprostadil alfadex Drug groups [BR:br08330] Hormonal agent DG01961 Prostaglandin derivative DG01611 Prostaglandin E1 derivative DG00239 Alprostadil | ||||||||
| Other DBs |
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| KCF data | ATOM 91 1 C1y C 7.9030 -14.4151 2 C1y C 7.8970 -15.8249 3 C5x C 6.5630 -13.9840 4 C1b C 9.1147 -13.7101 5 C1y C 6.5804 -16.2560 6 C2b C 9.1147 -16.5183 7 C1x C 5.7415 -15.1257 8 O5x O 6.1261 -12.6556 9 C1b C 10.3266 -14.4151 10 O1a O 6.1609 -17.5903 11 C2b C 10.3266 -15.8249 12 C1b C 11.5443 -13.7101 13 C1c C 11.5443 -16.5183 14 C1b C 12.7501 -14.4151 15 C1b C 12.7560 -15.8249 16 O1a O 11.5443 -17.9223 17 C1b C 13.9677 -13.7101 18 C1b C 13.9677 -16.5183 19 C1b C 15.1854 -14.4151 20 C1b C 15.1854 -15.8249 21 C6a C 16.3973 -13.7101 22 C1b C 16.3973 -16.5183 23 O6a O 17.6090 -14.4209 24 O6a O 16.3506 -12.3468 25 C1a C 17.6150 -15.8249 26 C1y C 34.2300 -11.4100 27 C1y C 32.9000 -11.4100 28 O2x O 32.2000 -12.6000 29 C1y C 32.9000 -13.7200 30 C1y C 34.2300 -13.7200 31 C1y C 34.9300 -12.5300 32 O2x O 32.9000 -16.4500 33 C1y C 34.2300 -16.4500 34 O2a O 34.9300 -15.0500 35 C1y C 32.2000 -17.6400 36 C1y C 32.9000 -18.8300 37 C1y C 34.2300 -18.8300 38 C1y C 34.9300 -17.6400 39 O1a O 36.2600 -12.5300 40 O1a O 34.9300 -20.0200 41 O1a O 34.9300 -10.2200 42 O1a O 36.2600 -17.6400 43 O2a O 32.2000 -10.2200 44 C1y C 30.3800 -10.2200 45 C1y C 29.6100 -11.4100 46 O2x O 29.6800 -18.8300 47 C1y C 30.3800 -20.0200 48 O2a O 32.2700 -20.0200 49 C1y C 29.6100 -9.1000 50 C1y C 28.2800 -9.0300 51 C1y C 27.5800 -10.2200 52 O2x O 28.2800 -11.4100 53 C1y C 28.3500 -18.8300 54 C1y C 27.6500 -20.0200 55 C1y C 28.3500 -21.2100 56 C1y C 29.6800 -21.2100 57 O1a O 30.3800 -22.4000 58 O1a O 27.5800 -7.8400 59 O1a O 30.3100 -7.8400 60 O2a O 25.7600 -10.2200 61 O1a O 27.6500 -22.4000 62 O2a O 25.8300 -20.0200 63 O2x O 25.8300 -17.7100 64 C1y C 25.2000 -18.9700 65 C1y C 25.2000 -11.4100 66 C1y C 25.8300 -12.6000 67 C1y C 23.8000 -11.4100 68 C1y C 23.1700 -12.6000 69 C1y C 23.8000 -13.7900 70 O2x O 25.2000 -13.7900 71 C1y C 25.2000 -16.5200 72 C1y C 23.8000 -16.5200 73 C1y C 23.1700 -17.7100 74 C1y C 23.8000 -18.9000 75 O1a O 23.1700 -10.2200 76 O2a O 23.1000 -15.1900 77 O1a O 21.7700 -17.7100 78 O1a O 21.7700 -12.6000 79 O1a O 23.1700 -20.0900 80 C1b C 27.5800 -17.6400 81 C1b C 25.9000 -15.3300 82 C1b C 27.1600 -12.6000 83 C1b C 30.3100 -12.6000 84 C1b C 32.2000 -14.9800 85 C1b C 30.8000 -17.6400 86 O1a O 28.3500 -16.5900 87 O1a O 27.3000 -15.3300 88 O1a O 27.8600 -13.7900 89 O1a O 29.9600 -14.0000 90 O1a O 30.8700 -15.0500 91 O1a O 30.1000 -16.3800 BOND 97 1 1 2 1 2 1 3 1 3 1 4 1 #Down 4 2 5 1 5 2 6 1 #Up 6 3 7 1 7 3 8 2 8 4 9 1 9 5 10 1 #Down 10 6 11 2 11 9 12 1 12 11 13 1 13 12 14 1 14 13 15 1 15 13 16 1 #Down 16 14 17 1 17 15 18 1 18 17 19 1 19 18 20 1 20 19 21 1 21 20 22 1 22 21 23 1 23 21 24 2 24 22 25 1 25 5 7 1 26 26 27 1 27 27 28 1 28 28 29 1 29 29 30 1 30 30 31 1 31 26 31 1 32 32 33 1 33 33 34 1 #Down 34 30 34 1 #Down 35 32 35 1 36 35 36 1 37 36 37 1 38 37 38 1 39 33 38 1 40 31 39 1 #Up 41 37 40 1 #Up 42 26 41 1 #Down 43 38 42 1 #Down 44 27 43 1 #Down 45 44 43 1 #Down 46 44 45 1 47 47 46 1 48 47 48 1 #Down 49 36 48 1 #Down 50 44 49 1 51 49 50 1 52 50 51 1 53 51 52 1 54 45 52 1 55 46 53 1 56 53 54 1 57 54 55 1 58 55 56 1 59 47 56 1 60 56 57 1 #Down 61 50 58 1 #Down 62 49 59 1 #Up 63 51 60 1 #Down 64 55 61 1 #Up 65 54 62 1 #Down 66 63 64 1 67 64 62 1 #Down 68 65 60 1 #Down 69 65 66 1 70 65 67 1 71 67 68 1 72 68 69 1 73 69 70 1 74 66 70 1 75 63 71 1 76 71 72 1 77 72 73 1 78 73 74 1 79 64 74 1 80 67 75 1 #Up 81 69 76 1 #Down 82 72 76 1 #Down 83 73 77 1 #Up 84 68 78 1 #Down 85 74 79 1 #Down 86 53 80 1 #Up 87 71 81 1 #Up 88 66 82 1 #Up 89 45 83 1 #Up 90 29 84 1 #Up 91 35 85 1 #Up 92 80 86 1 93 81 87 1 94 82 88 1 95 83 89 1 96 84 90 1 97 85 91 1 BRACKET 1 19.9500 -23.1000 19.9500 -6.9300 1 37.9400 -6.9300 37.9400 -23.1000 1 x ORIGINAL 1 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 1 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 1 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 1 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 1 90 91 REPEAT 1 |