Valganciclovir hydrochloride

Entry

D03256                      Drug

Name

Valganciclovir hydrochloride (JAN/USP);
Valcyte (TN)

Product

VALCYTE (Genentech)

Generic

VALGANCICLOVIR (Ajanta Pharma USA), VALGANCICLOVIR (American Health Packaging), VALGANCICLOVIR (AvPAK), VALGANCICLOVIR (Camber Pharmaceuticals), VALGANCICLOVIR (Cipla USA), VALGANCICLOVIR (Dr. Reddy's Laboratories Limited), VALGANCICLOVIR (Golden State Medical Supply), VALGANCICLOVIR HYDROCHLORIDE (Granules Pharmaceuticals), VALGANCICLOVIR (Major Pharmaceuticals), VALGANCICLOVIR (McKesson Corporation DBA SKY Packaging), VALGANCICLOVIR (NorthStar Rx LLC), VALGANCICLOVIR (Safecor Health), VALGANCICLOVIR HYDROCHLORIDE (Somerset Therapeutics), VALGANCICLOVIR (airis PHARMA PVT), VALGANCICLOVIR HYDROCHLORIDE FOR ORAL (Actavis Pharma), VALGANCICLOVIR HYDROCHLORIDE (Ajanta Pharma USA), VALGANCICLOVIR HYDROCHLORIDE (Aurobindo Pharma Limited), VALGANCICLOVIR (AvKARE), VALGANCICLOVIR (Bryant Ranch Prepack), VALGANCICLOVIR HYDROCHLORIDE (Dr. Reddy's Laboratories), VALGANCICLOVIR HYDROCHLORIDE (Mckesson Corporation DBA SKY Packaginng), VALGANCICLOVIR (Par Pharmaceutical)

Formula

C14H22N6O5. HCl

Exact mass

390.1418

Mol weight

390.8226

Structure

Simcomp

Class

Antiviral
DG01937 Anti-cytomegalovirus agent

Remark

Therapeutic category:

6250

ATC code:

J05AB14

Chemical structure group:

DG00649

Product (DG00649):

D03256<JP/US>

Efficacy

Antiviral, DNA polymerase inhibitor

Disease

Cytomegalovirus (CMV) retinitis [DS:H00368]

Comment

Active form of prodrug: Ganciclovir [DR:D00333]

Target

HCMV DNA polymerase [KO:K18964]

Pathway

ko03240

Viral replication

Interaction

Structure map

map07044

Antiviral agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors
     J05AB14 Valganciclovir
      D03256  Valganciclovir hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Antivirals
  Anti-cytomegalovirus (CMV) Agents
   Valganciclovir
    D03256  Valganciclovir hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D03256  Valganciclovir hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Antiviral
  DG01937  Anti-cytomegalovirus agent
   DG00649  Valganciclovir
    D03256  Valganciclovir hydrochloride
Drug classes [BR:br08332]
Antiviral
  DG01937  Anti-cytomegalovirus agent
   D03256  Valganciclovir hydrochloride
Antimicrobials [BR:br08307]
Antivirals
  Genome replication inhibitor
   Herpesvirus DNA polymerase inhibitor
    D03256  Valganciclovir hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D03256
Drug groups [BR:br08330]
Antiviral
  DG01937  Anti-cytomegalovirus agent
   DG00649  Valganciclovir
Antimicrobials abbreviations [BR:br08327]
Antivirals
  Genome replication inhibitor
   Herpesvirus DNA polymerase inhibitor
    DG00649  Valganciclovir
Prodrugs [br08324.html]
DG00649

Other DBs

CAS:	175865-59-5

PubChem:

17397409

LigandBox:

D03256

KCF data

ATOM        26
            1   C8y C    27.4400  -16.6600
            2   C8y C    27.4400  -15.2600
            3   N4y N    26.1800  -17.2200
            4   N4x N    28.7700  -17.3600
            5   N5x N    26.1100  -14.9100
            6   C8y C    28.5600  -14.4900
            7   C8x C    25.3400  -16.1000
            8   C8y C    29.8900  -16.5900
            9   N5x N    29.8900  -15.1200
            10  O5x O    28.5600  -13.0900
            11  N1a N    31.1500  -17.2200
            12  C1b C    26.1800  -18.6200
            13  O2a O    24.9900  -19.3200
            14  C1c C    23.8000  -18.6200
            15  C1b C    22.6100  -19.3200
            16  C1b C    23.8000  -17.2200
            17  O7a O    21.4200  -18.6900
            18  C7a C    20.2300  -19.3200
            19  C1c C    19.0400  -18.6900
            20  C1c C    17.8500  -19.3200
            21  O1a O    22.6100  -16.5900
            22  O6a O    20.2300  -20.7900
            23  C1a C    16.6600  -18.6900
            24  C1a C    17.8500  -20.7900
            25  N1a N    19.0400  -17.2200
            26  X   Cl   34.6500  -15.8900
BOND        26
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     6   9 1
            9     6  10 2
            10    8  11 1
            11    5   7 2
            12    8   9 2
            13    3  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   14  16 1
            18   15  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   16  21 1
            23   18  22 2
            24   20  23 1
            25   20  24 1
            26   19  25 1 #Down