Desonide

Entry

D03696                      Drug

Name

Desonide (USP/INN);
Desowen (TN);
Verdeso (TN)

Product

VERDESO (Almirall), DESONATE (Bayer HealthCare Pharmaceuticals), DESOWEN (Galderma Laboratories), DESONATE (LEO Pharma), DESONIDE (Padagis Israel Pharmaceuticals), DESONIDE (Padagis Israel Pharmaceuticals), TRIDESILON CREAM (Encore Dermatology)

Generic

DESONIDE (Actavis Pharma), DESONIDE (Alembic Pharmaceuticals), DESONIDE (Alembic Pharmaceuticals), DESONIDE (Aleor Dermaceuticals Limited), DESONIDE (Aleor Dermaceuticals Limited), DESONIDE (Amneal Pharmaceuticals of New York LLC), DESONIDE (Bryant Ranch Prepack), DESONIDE (Bryant Ranch Prepack), DESONIDE (Bryant Ranch Prepack), DESONIDE (Cadila Healthcare Limited), DESONIDE (Cintex Services), DESONIDE (Cosette Pharmaceuticals), DESONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), DESONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), DESRX (Eckson Labs), DESONIDE (Glenmark Pharmaceuticals), DESONIDE (Glenmark Pharmaceuticals), DESONIDE (Glenmark Pharmaceuticals), DESONIDE (KMM Pharmaceuticals), DESONIDE (NORTHSTAR RX LLC), DESONIDE (Northstar Rx LLC), DESONIDE (Proficient Rx LP), DESONIDE (Taro Pharmaceuticals U.S.A.), DESONIDE (Taro Pharmaceuticals U.S.A.), DESONIDE (Teligent Pharma), DESONIDE (Unit Dose Services), DESONIDE (Viona Pharmaceuticals), DESONIDE OINTMENT, 0.05% (Bryant Ranch Prepack), DESONIDE OINTMENT, 0.05% (Bryant Ranch Prepack), DESONIDE OINTMENT, 0.05% (Encube Ethicals Private Limited)

Formula

C24H32O6

Exact mass

416.2199

Mol weight

416.5073

Structure

Simcomp

Class

Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid

Remark

ATC code:

D07AB08 S01BA11

Product:

D03696<US>

Efficacy

Anti-inflammatory, Glucocorticoid receptor agonist

Disease

Atopic dermatitis [DS:H01358]

Target

NR3C1 (GR) [HSA:2908] [KO:K05771]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB08 Desonide
      D03696  Desonide (USP/INN) <US>
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA11 Desonide
      D03696  Desonide (USP/INN) <US>
USP drug classification [BR:br08302]
Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Low Potency
    Desonide
     D03696  Desonide (USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    D03696  Desonide
Drug classes [BR:br08332]
Anti-inflammatory
  DG01955  Corticosteroid
   D03696  Desonide
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D03696  Desonide (USP/INN) <US>
Topical steroids potency [br08317.html]
Classification in the USA
  D03696

Other DBs

CAS:

638-94-8

PubChem:

17397789

ChEBI:

204734

LigandBox:

D03696

NIKKAJI:

J6.927B

KCF data

ATOM        30
            1   C2x C    29.0870  -20.6780
            2   C5x C    29.0870  -22.0509
            3   C2x C    30.2760  -22.7374
            4   C2y C    31.4650  -22.0509
            5   C1z C    31.4650  -20.6780
            6   C2x C    30.2760  -19.9916
            7   C1x C    32.6539  -22.7374
            8   C1x C    33.8429  -22.0509
            9   C1y C    33.8429  -20.6780
            10  C1y C    32.6539  -19.9916
            11  C1y C    35.0319  -19.9916
            12  C1z C    35.0319  -18.6187
            13  C1x C    33.8429  -17.9322
            14  C1y C    32.6539  -18.6187
            15  C1x C    37.4098  -19.9916
            16  C1y C    37.4098  -18.6187
            17  C1z C    36.2208  -17.9322
            18  O2x O    38.7827  -18.6187
            19  C1z C    38.7827  -17.2458
            20  C1a C    38.7827  -15.8728
            21  O2x O    37.4098  -17.2458
            22  C1a C    40.1556  -17.2458
            23  C5a C    36.2208  -16.2793
            24  O5a O    37.4138  -15.5906
            25  C1b C    35.0358  -15.5951
            26  O5x O    27.8981  -22.7374
            27  C1a C    31.4650  -19.3051
            28  O1a O    31.4670  -17.9334
            29  C1a C    35.0319  -17.2458
            30  O1a O    33.8431  -16.2843
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21   16  18 1 #Down
            22   18  19 1
            23   19  20 1
            24   17  21 1 #Down
            25   21  19 1
            26   19  22 1
            27   17  23 1 #Up
            28   23  24 2
            29   23  25 1
            30    2  26 2
            31    5  27 1 #Up
            32   14  28 1 #Up
            33   12  29 1 #Up
            34   25  30 1