| Entry |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | Desoximetasone (USP/INN); Topicort (TN) | ||||||||||
| Product | DESOXIMETASONE (Taro Pharmaceuticals U.S.A.), TOPICORT (Taro Pharmaceuticals U.S.A.), TOPICORT (Taro Pharmaceuticals U.S.A.) | ||||||||||
| Generic | DESOXIMETASONE (A-S Medication Solutions), DESOXIMETASONE (A-S Medication Solutions), DESOXIMETASONE (A-S Medication Solutions), DESOXIMETASONE (Actavis Pharma), DESOXIMETASONE (Actavis Pharma), DESOXIMETASONE (Bryant Ranch Prepack), DESOXIMETASONE (Bryant Ranch Prepack), DESOXIMETASONE (Bryant Ranch Prepack), DESOXIMETASONE (Cadila Healthcare Limited), DESOXIMETASONE (Cadila Healthcare Limited), DESOXIMETASONE (Cosette Pharmaceuticals), DESOXIMETASONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), DESOXIMETASONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), DESOXIMETASONE (Glenmark Pharmaceuticals), DESOXIMETASONE (Lupin Pharmaceuticals), DESOXIMETASONE (Lupin Pharmaceuticals), DESOXIMETASONE (Lupin Pharmaceuticals), DESOXIMETASONE (Lupin Pharmaceuticals), DESOXIMETASONE (Lupin Pharmaceuticals), DESOXIMETASONE (Novel Laboratories), DESOXIMETASONE (Padagis Israel Pharmaceuticals), DESOXIMETASONE (Padagis Israel Pharmaceuticals), DESOXIMETASONE (Padagis Israel Pharmaceuticals), DESOXIMETASONE (Proficient Rx LP), DESOXIMETASONE (Proficient Rx LP), DESOXIMETASONE (RPK Pharmaceuticals), DESOXIMETASONE (Rising Pharmaceuticals), DESOXIMETASONE (Rising Pharmaceuticals), TOPICORT (Taro Pharmaceuticals U.S.A.), DESOXIMETASONE (Taro Pharmaceuticals U.S.A.), TOPICORT (Taro Pharmaceuticals U.S.A.), DESOXIMETASONE (Taro Pharmaceuticals U.S.A.), DESOXIMETASONE (Taro Pharmaceuticals U.S.A.), DESOXIMETASONE (Teligent Pharma), DESOXIMETASONE (Teligent Pharma), DESOXIMETASONE (Viona Pharmaceuticals), DESOXIMETASONE (Viona Pharmaceuticals), DESOXIMETASONE OINT 0.05% (Preferred Pharmaceuticals), DESOXIMETASONE OINT 0.05% (SOLA Pharmaceuticals) | ||||||||||
| Formula | C22H29FO4 | ||||||||||
| Exact mass | 376.205 | ||||||||||
| Mol weight | 376.4617 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Class | Anti-inflammatory DG01955 Corticosteroid DG02068 Glucocorticoid | ||||||||||
| Remark |
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| Efficacy | Anti-inflammatory, Glucocorticoid receptor agonist | ||||||||||
| Disease | Plaque psoriasis [DS:H01656] | ||||||||||
| Target | NR3C1 (GR) [HSA:2908] [KO:K05771] | ||||||||||
| Pathway |
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| Interaction | |||||||||||
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] D DERMATOLOGICALS D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS D07A CORTICOSTEROIDS, PLAIN D07AC Corticosteroids, potent (group III) D07AC03 Desoximetasone D03697 Desoximetasone (USP/INN) <US> D07X CORTICOSTEROIDS, OTHER COMBINATIONS D07XC Corticosteroids, potent, other combinations D07XC02 Desoximetasone D03697 Desoximetasone (USP/INN) <US> USP drug classification [BR:br08302] Dermatological Agents Dermatitis and Pruitus Agents Glucocorticoids, Medium Potency Desoximetasone D03697 Desoximetasone (USP/INN) Glucocorticoids, High Potency Desoximetasone D03697 Desoximetasone (USP/INN) Drug groups [BR:br08330] Anti-inflammatory DG01955 Corticosteroid DG02068 Glucocorticoid D03697 Desoximetasone Drug classes [BR:br08332] Anti-inflammatory DG01955 Corticosteroid D03697 Desoximetasone Target-based classification of drugs [BR:br08310] Nuclear receptors Estrogen like receptors 3-Ketosteroid receptor NR3C1 (GR) D03697 Desoximetasone (USP/INN) <US> Topical steroids potency [br08317.html] Classification in the USA D03697 | ||||||||||
| Other DBs |
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| KCF data | ATOM 27 1 C2x C 24.2900 -24.2900 2 C5x C 24.2900 -25.6900 3 C2x C 25.5024 -26.3900 4 C2y C 26.7149 -25.6900 5 C1z C 26.7149 -24.2900 6 C2x C 25.5024 -23.5900 7 C1x C 27.9273 -26.3900 8 C1x C 29.1397 -25.6900 9 C1y C 29.1397 -24.2900 10 C1z C 27.9273 -23.5900 11 C1y C 30.3522 -23.5900 12 C1z C 30.3522 -22.1900 13 C1x C 29.1397 -21.4900 14 C1y C 27.9273 -22.1900 15 C1x C 32.7770 -23.5900 16 C1y C 32.7770 -22.1900 17 C1y C 31.5646 -21.4900 18 C1a C 33.9766 -21.4973 19 C5a C 31.5646 -19.8800 20 C1a C 30.3522 -20.7900 21 O1a O 26.7169 -21.4912 22 C1a C 26.7149 -22.8900 23 X F 27.9273 -24.9900 24 O5x O 23.0776 -26.3900 25 O5a O 32.7811 -19.1777 26 C1b C 30.3562 -19.1823 27 O1a O 29.1627 -19.8716 BOND 30 1 1 2 1 2 2 3 1 3 3 4 2 4 4 5 1 5 5 6 1 6 1 6 2 7 4 7 1 8 7 8 1 9 8 9 1 10 9 10 1 11 5 10 1 12 9 11 1 13 11 12 1 14 12 13 1 15 13 14 1 16 10 14 1 17 11 15 1 18 15 16 1 19 16 17 1 20 12 17 1 21 16 18 1 #Down 22 17 19 1 #Up 23 12 20 1 #Up 24 14 21 1 #Up 25 5 22 1 #Up 26 10 23 1 #Down 27 2 24 2 28 19 25 2 29 19 26 1 30 26 27 1 |