Entry

D04008                      Drug

Name

Entecavir (USP);
Entecavir hydrate (JAN);
Baraclude (TN)

Product

BARACLUDE (E.R. Squibb & Sons)

Generic

ENTECAVIR (Accord Healthcare), ENTECAVIR (American Health Packaging), ENTECAVIR (Amneal Pharmaceuticals LLC), ENTECAVIR (Aurobindo Pharma Limited), ENTECAVIR (AvKARE), ENTECAVIR (AvPAK), ENTECAVIR (Breckenridge Pharmaceutical), ENTECAVIR (BrightGene Bio-Medical Technology), ENTECAVIR (Camber Pharmaceuticals), ENTECAVIR (Cipla USA), ENTECAVIR (EPIC PHARMA), ENTECAVIR (Florida Pharmaceutical Products), ENTECAVIR (Golden State Medical Supply), ENTECAVIR (NorthStar RxLLC), ENTECAVIR (Pharmadax), ENTECAVIR (Solco Healthcare LLC), ENTECAVIR (YUNG SHIN PHARM. IND.), ENTECAVIR (Zydus Lifesciences Limited), ENTECAVIR (Zydus Pharmaceuticals (USA))

Formula

C12H15N5O3. H2O

Exact mass

295.1281

Mol weight

295.2945

Structure

Simcomp

Class

Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)

Remark

Therapeutic category:

6250

ATC code:

J05AF10

Chemical structure group:

DG00661

Product (DG00661):

D04008<JP/US>

Efficacy

Antiviral, Reverse transcriptase inhibitor

Disease

Hepatitis B [DS:H00412]

Target

HBV reverse transcriptase [KO:K21037]

Pathway

ko03230

Viral genome structure

ko03240

Viral replication

ko05161

Hepatitis B

Structure map

map07044

Antiviral agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF10 Entecavir
      D04008  Entecavir (USP) <JP/US>
USP drug classification [BR:br08302]
Antivirals
  Anti-hepatitis B (HBV) Agents
   Entecavir
    D04008  Entecavir (USP)
Therapeutic category of drugs in Japan [BR:br08301]
6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D04008  Entecavir (USP); Entecavir hydrate (JAN)
Drug groups [BR:br08330]
Antiviral
  DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
   DG00661  Entecavir
    D04008  Entecavir
Antimicrobials [BR:br08307]
Antivirals
  Genome replication inhibitor
   HBV reverse transcriptase inhibitor
    D04008  Entecavir (USP) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D04008
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D04008
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D04008
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D04008
Drug groups [BR:br08330]
Antiviral
  DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
   DG00661  Entecavir
Antimicrobials abbreviations [BR:br08327]
Antivirals
  Genome replication inhibitor
   HBV reverse transcriptase inhibitor
    DG00661  Entecavir

Other DBs

CAS:	209216-23-9

PubChem:

17398002

ChEBI:

59902

LigandBox:

D04008

KCF data

ATOM        21
            1   O0  O    30.7234  -17.2838
            2   C8y C    23.0300  -15.3300
            3   C8y C    23.0300  -16.8000
            4   C8y C    24.0100  -14.6300
            5   N5x N    21.7000  -14.9800
            6   N4y N    21.7700  -17.2900
            7   N5x N    24.2200  -17.4300
            8   O5x O    24.0100  -13.2300
            9   N4x N    25.3400  -15.1900
            10  C8x C    20.8600  -16.1700
            11  C1y C    20.1600  -18.4100
            12  C8y C    25.3400  -16.7300
            13  C2y C    19.0400  -17.5700
            14  C1x C    19.6700  -19.6000
            15  N1a N    26.6000  -17.2900
            16  C1y C    17.9200  -18.2700
            17  C1y C    18.3400  -19.6000
            18  C1b C    16.6600  -17.8500
            19  O1a O    15.6100  -18.6900
            20  C2a C    19.0400  -16.1700
            21  O1a O    17.5000  -20.7200
BOND        22
            1     2   3 2
            2     2   4 1
            3     2   5 1
            4     3   6 1
            5     3   7 1
            6     4   8 2
            7     4   9 1
            8     5  10 2
            9    11   6 1 #Up
            10    7  12 2
            11   11  13 1
            12   11  14 1
            13   12  15 1
            14   13  16 1
            15   14  17 1
            16   16  18 1 #Up
            17   18  19 1
            18    6  10 1
            19    9  12 1
            20   16  17 1
            21   13  20 2
            22   17  21 1 #Down