Ganciclovir sodium

Entry

D04301                      Drug

Name

Ganciclovir sodium (USAN);
Cytovene IV (TN)

Product

CYTOVENE (H2-Pharma)

Generic

GANCICLOVIR (Par Pharmaceutical), GANCICLOVIR (Fresenius Kabi USA), GANCICLOVIR (Fresenius Kabi USA), GANCICLOVIR (Hikma Pharmaceuticals USA), GANCICLOVIR (Pharmascience), GANCICLOVIR (Sagent Pharmaceuticals), GANCICLOVIR (Slate Run Pharmaceuticals)

Formula

C9H12N5O4. Na

Exact mass

277.0787

Mol weight

277.2124

Structure

Simcomp

Class

Antiviral
DG02840 Anti-herpesvirus agent
DG01937 Anti-cytomegalovirus agent

Remark

ATC code:

J05AB06 S01AD09

Chemical structure group:

DG00646

Product (DG00646):

D00333<JP/US> D04301<US>

Efficacy

Antiviral, DNA polymerase inhibitor

Disease

CMV retinitis [DS:H00368]

Target

HCMV DNA polymerase [KO:K18964]

Pathway

ko03240

Viral replication

Interaction

Structure map

map07044

Antiviral agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors
     J05AB06 Ganciclovir
      D04301  Ganciclovir sodium (USAN) <US>
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AD Antivirals
     S01AD09 Ganciclovir
      D04301  Ganciclovir sodium (USAN) <US>
USP drug classification [BR:br08302]
Antivirals
  Anti-cytomegalovirus (CMV) Agents
   Ganciclovir
    D04301  Ganciclovir sodium (USAN)
Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antiviral, Ophthalmic
    Ganciclovir
     D04301  Ganciclovir sodium (USAN)
Drug groups [BR:br08330]
Antiviral
  DG02840  Anti-herpesvirus agent
   DG00646  Ganciclovir
    D04301  Ganciclovir sodium
  DG01937  Anti-cytomegalovirus agent
   DG00646  Ganciclovir
    D04301  Ganciclovir sodium
Drug classes [BR:br08332]
Antiviral
  DG02840  Anti-herpesvirus agent
   D04301  Ganciclovir sodium
  DG01937  Anti-cytomegalovirus agent
   D04301  Ganciclovir sodium
Antimicrobials [BR:br08307]
Antivirals
  Genome replication inhibitor
   Herpesvirus DNA polymerase inhibitor
    D04301  Ganciclovir sodium (USAN) <US>
Drug groups [BR:br08330]
Antiviral
  DG02840  Anti-herpesvirus agent
   DG00646  Ganciclovir
  DG01937  Anti-cytomegalovirus agent
   DG00646  Ganciclovir
Antimicrobials abbreviations [BR:br08327]
Antivirals
  Genome replication inhibitor
   Herpesvirus DNA polymerase inhibitor
    DG00646  Ganciclovir

Other DBs

CAS:	107910-75-8

PubChem:

47206231

LigandBox:

D04301

NIKKAJI:

J399.156C

KCF data

ATOM        19
            1   N4y N    17.7005  -17.0904
            2   C8y C    18.9563  -16.6020
            3   C8y C    18.9563  -15.2067
            4   N5x N    17.6307  -14.8578
            5   C8x C    16.8633  -15.9741
            6   N5x N    20.3516  -17.2997
            7   C8y C    21.3981  -16.5322
            8   N5x N    21.3981  -15.1369
            9   C8y C    20.1423  -14.5090
            10  O1a O    20.1423  -13.1137 #-
            11  N1a N    22.6539  -17.2299
            12  C1b C    17.7005  -18.5554
            13  O2a O    16.5145  -19.2531
            14  C1c C    15.2587  -18.5554
            15  C1b C    14.1424  -19.2531
            16  C1b C    15.2587  -17.0904
            17  O1a O    14.0726  -16.3927
            18  O1a O    12.8866  -18.5554
            19  Z   Na   21.9480  -12.8288 #+
BOND        19
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     1   5 1
            6     2   6 1
            7     6   7 2
            8     7   8 1
            9     8   9 2
            10    3   9 1
            11    9  10 1
            12    7  11 1
            13    1  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   14  16 1
            18   16  17 1
            19   15  18 1