Halobetasol propionate

Entry

D04409                      Drug

Name

Halobetasol propionate (USP);
Ulobetasol propionate;
Ultravate (TN)

Product

BRYHALI (Bausch Health US), LEXETTE (Mayne Pharma), HALOBETASOL PROPIONATE (Mayne Pharma), ULTRAVATE (Sun Pharmaceutical Industries)

Generic

HALOBETASOL PROPIONATE (Bryant Ranch Prepack), HALOBETASOL PROPIONATE (Bryant Ranch Prepack), HALOBETASOL PROPIONATE (Bryant Ranch Prepack), HALOBETASOL PROPIONATE (Cosette Pharmaceuticals), HALOBETASOL PROPIONATE (Cosette Pharmaceuticals), HALOBETASOL PROPIONATE (Cosette Pharmaceuticals), HALOBETASOL PROPIONATE (Fougera Pharmaceuticals), HALOBETASOL PROPIONATE (McKesson Corporation), HALOBETASOL PROPIONATE (Padagis Israel Pharmaceuticals), HALOBETASOL PROPIONATE (Padagis Israel Pharmaceuticals), HALOBETASOL PROPIONATE (QUAGEN PHARMACEUTICALS LLC), HALOBETASOL PROPIONATE (Taro Pharmaceuticals U.S.A.), HALOBETASOL PROPIONATE (Taro Pharmaceuticals U.S.A.), HALOBETASOL PROPIONATE (Teligent Pharma), HALOBETASOL PROPIONATE (Sola Pharmaceuticals)

Formula

C25H31ClF2O5

Exact mass

484.1828

Mol weight

484.9604

Structure

Simcomp

Class

Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid

Remark

ATC code:

D07AC21

Chemical structure group:

DG00421

Product (DG00421):

D04409<US>

Product (mixture):

D11932<US>

Efficacy

Anti-inflammatory, Glucocorticoid receptor agonist

Disease

Plaque psoriasis [DS:H01656]

Target

NR3C1 (GR) [HSA:2908] [KO:K05771]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC21 Ulobetasol
      D04409  Halobetasol propionate (USP) <US>
USP drug classification [BR:br08302]
Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Very High Potency
    Halobetasol
     D04409  Halobetasol propionate (USP)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00421  Halobetasol
     D04409  Halobetasol propionate
Drug classes [BR:br08332]
Anti-inflammatory
  DG01955  Corticosteroid
   D04409  Halobetasol propionate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D04409  Halobetasol propionate (USP) <US>
Topical steroids potency [br08317.html]
Classification in the USA
  D04409
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00421  Halobetasol

Other DBs

CAS:	66852-54-8

PubChem:

47206289

LigandBox:

D04409

KCF data

ATOM        33
            1   C2x C    15.2600  -25.4100
            2   C5x C    15.2600  -26.8100
            3   C2x C    16.4500  -27.5100
            4   C2y C    17.7100  -26.8100
            5   C1z C    17.7100  -25.4100
            6   C2x C    16.4500  -24.7100
            7   C1y C    18.9000  -27.5100
            8   C1x C    20.0900  -26.8100
            9   C1y C    20.0900  -25.4100
            10  C1z C    18.9000  -24.7100
            11  C1y C    21.3500  -24.7100
            12  C1z C    21.3500  -23.3100
            13  C1x C    20.0900  -22.6100
            14  C1y C    18.9000  -23.3100
            15  C1x C    23.7300  -24.7100
            16  C1y C    23.7300  -23.3100
            17  C1z C    22.5400  -22.6100
            18  O5x O    14.0700  -27.5100
            19  C1a C    17.7100  -24.0100
            20  X   F    18.9000  -26.1100
            21  X   F    18.9000  -28.9100
            22  O1a O    17.7100  -22.6100
            23  C1a C    21.3500  -21.9100
            24  O7a O    23.7300  -21.9100
            25  C7a C    25.1300  -21.9100
            26  O6a O    25.8300  -20.6975
            27  C1b C    25.8300  -23.1224
            28  C1a C    27.2298  -23.1224
            29  C5a C    22.5400  -20.9300
            30  O5a O    23.7524  -20.2300
            31  C1b C    21.3276  -20.2300
            32  X   Cl   20.1321  -20.9204
            33  C1a C    25.1417  -23.1902
BOND        36
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   10  20 1 #Down
            24    7  21 1 #Down
            25   14  22 1 #Up
            26   12  23 1 #Up
            27   17  24 1 #Down
            28   24  25 1
            29   25  26 2
            30   25  27 1
            31   27  28 1
            32   17  29 1 #Up
            33   29  30 2
            34   29  31 1
            35   31  32 1
            36   16  33 1 #Up