Lenalidomide

Entry

D04687                      Drug

Name

Lenalidomide (JAN/USAN/INN);
Revlimid (TN)

Product

REVLIMID (Celgene Corporation)

Generic

LENALIDOMIDE (Teva Pharmaceuticals)

Formula

C13H13N3O3

Exact mass

259.0957

Mol weight

259.2606

Structure

Simcomp

Class

Anti-inflammatory
DG01985 Disease modifying anti-rheumatic drug (DMARD)
DG01936 TNF inhibitor

Remark

ATC code:

L04AX04

Chemical structure group:

DG00744

Product (DG00744):

D04687<US> D09813<JP>

Efficacy

Antineoplastic, Immunomodulator, TNF-alpha inhibitor

Disease

Multiple myeloma [DS:H00010]
Myelodysplastic syndromes (chromosome 5q deletion) [DS:H01484]
Mantle cell lymphoma [DS:H01464]
Follicular lymphoma [DS:H01613]

Comment

Thalidomide [DR:D00754] derivative

Target

TNF (TNFA, TNFSF2) [HSA:7124] [KO:K03156]

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04064

NF-kappa B signaling pathway

hsa04210

Apoptosis

hsa04640

Hematopoietic cell lineage

hsa04650

Natural killer cell mediated cytotoxicity

hsa04668

TNF signaling pathway

Interaction

Structure map

map07046

Immunosuppressive agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AX Other immunosuppressants
     L04AX04 Lenalidomide
      D04687  Lenalidomide (JAN/USAN/INN) <US>
USP drug classification [BR:br08302]
Antineoplastics
  Antiangiogenic Agents
   Lenalidomide
    D04687  Lenalidomide (JAN/USAN/INN)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01985  Disease modifying anti-rheumatic drug (DMARD)
   DG01936  TNF inhibitor
    DG00744  Lenalidomide
     D04687  Lenalidomide
Drug classes [BR:br08332]
Immunological agent
  DG01936  TNF inhibitor
   D04687  Lenalidomide
Antirheumatic agent
  DG01985  Disease modifying anti-rheumatic drug (DMARD)
   D04687  Lenalidomide
Target-based classification of drugs [BR:br08310]
Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNF (TNFA, TNFSF2)
     D04687  Lenalidomide (JAN/USAN/INN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D04687
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D04687
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D04687
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D04687
Drug groups [BR:br08330]
Anti-inflammatory
  DG01985  Disease modifying anti-rheumatic drug (DMARD)
   DG01936  TNF inhibitor
    DG00744  Lenalidomide

Other DBs

CAS:	191732-72-6

PubChem:

47206522

ChEBI:

63791

LigandBox:

D04687

NIKKAJI:

J1.121.689G

KCF data

ATOM        19
            1   C8x C    12.8800  -15.7500
            2   C8x C    12.8800  -17.1500
            3   C8x C    14.0924  -17.8500
            4   C8y C    15.3049  -17.1500
            5   C8y C    15.3049  -15.7500
            6   C8y C    14.0924  -15.0500
            7   C5x C    16.6364  -17.5826
            8   N1y N    17.4593  -16.4500
            9   C1x C    16.6364  -15.3174
            10  C1y C    18.8300  -16.4500
            11  O5x O    17.0675  -18.9094
            12  N1a N    14.0924  -13.6502
            13  C1x C    19.5300  -17.6624
            14  C1x C    20.9300  -17.6624
            15  C5x C    21.6300  -16.4500
            16  N1x N    20.9300  -15.2376
            17  C5x C    19.5300  -15.2376
            18  O5x O    18.8396  -14.0421
            19  O5x O    23.0300  -16.4500
BOND        21
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12    7  11 2
            13    6  12 1
            14   10  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   10  17 1
            20   17  18 2
            21   15  19 2