Maribavir

Entry

D04859                      Drug

Name

Maribavir (JAN/USAN/INN);
Camvia (TN);
Livtencity (TN)

Product

LIVTENCITY (Takeda Pharmaceuticals America)

Formula

C15H19Cl2N3O4

Exact mass

375.0753

Mol weight

376.2351

Structure

Class

Antiviral
DG01937  Anti-cytomegalovirus agent
Metabolizing enzyme substrate
DG01892  CYP1A2 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

ATC code:

J05AX10

Product:

D04859<US>

Efficacy

Antiviral

Disease

Cytomegalovirus infection [DS:H00368]

Comment

L-ribofuranosyl nucleoside
Treatment of cytomegalovirus infections

Target

HCMV pUL97 protein kinase

Metabolism

Enzyme: CYP3A4 [HSA:1576]; CYP1A2 [HSA:1544]

Interaction

Structure map

map07044

Antiviral agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AX Other antivirals
     J05AX10 Maribavir
      D04859  Maribavir (JAN/USAN/INN) <US>
Drug groups [BR:br08330]
Antiviral
  DG01937  Anti-cytomegalovirus agent
   D04859  Maribavir
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   D04859  Maribavir
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D04859  Maribavir
Drug classes [BR:br08332]
Antiviral
  DG01937  Anti-cytomegalovirus agent
   D04859  Maribavir
Antimicrobials [BR:br08307]
Antivirals
  Genome replication inhibitor
   Other inhibitor
    D04859  Maribavir (JAN/USAN/INN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D04859
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D04859
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D04859

Other DBs

CAS:	176161-24-3

PubChem:

47206634

LigandBox:

D04859

NIKKAJI:

J1.159.817J

KCF data

ATOM        24
            1   C1y C    12.7400  -27.0900
            2   C1y C    11.3400  -27.0900
            3   C1y C    10.9200  -25.7600
            4   O2x O    12.0400  -24.9900
            5   C1y C    13.1600  -25.7600
            6   O1a O    13.5100  -28.2100
            7   O1a O    10.5700  -28.2100
            8   C1b C     9.7300  -25.0600
            9   O1a O     8.5400  -25.7600
            10  N4y N    14.3500  -25.0600
            11  C8y C    17.9491  -27.0906
            12  C8y C    16.7944  -27.8823
            13  C8x C    15.5441  -27.2967
            14  C8y C    15.4089  -25.8617
            15  C8y C    16.5636  -25.0700
            16  C8x C    17.8534  -25.7133
            17  C8y C    14.8383  -23.7916
            18  N5x N    16.1974  -23.7933
            19  N1b N    14.0466  -22.6369
            20  C1c C    14.6322  -21.3867
            21  C1a C    13.8800  -20.2898
            22  C1a C    15.9517  -21.4006
            23  X   Cl   16.9296  -29.3173
            24  X   Cl   19.2389  -27.7339
BOND        26
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1 #Up
            7     2   7 1 #Up
            8     3   8 1 #Down
            9     8   9 1
            10    5  10 1 #Down
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   11  16 1
            17   14  10 1
            18   17  18 2
            19   15  18 1
            20   17  19 1
            21   19  20 1
            22   20  21 1
            23   20  22 1
            24   12  23 1
            25   11  24 1
            26   10  17 1