Entry

D05343                      Drug

Name

Palonosetron hydrochloride (JAN/USP);
Aloxi (TN)

Product

ALOXI (Eisai), ALOXI (Helsinn Therapeutics (U.S.)), ALOXI (Helsinn Therapeutics (U.S.)), PALONOSETRON HYDROCHLORIDE (West-Ward Pharmaceuticals Corp)

Generic

PALONOSETRON (BluePoint Laboratories), PALONOSETRON (Dr.Reddy's Laboratories Limited), PALONOSETRON (Fresenius Kabi USA), PALONOSETRON (Fresenius Kabi USA), PALONOSETRON (NorthStar Rx LLC), PALONOSETRON HYDROCHLORIDE (Accord Healthcare), PALONOSETRON (Apotex Corp.), PALONOSETRON HYDROCHLORIDE (AuroMedics Pharma LLC), PALONOSETRON HYDROCHLORIDE (Baxter Healthcare Corporation), PALONOSETRON (BluePoint Laboratories), PALONOSETRON HYDROCHLORIDE (Cipla USA), PALONOSETRON HYDROCHLORIDE (Hospira), PALONOSETRON HYDROCHLORIDE (Ingenus Pharmaceuticals), PALONOSETRON HYDROCHLORIDE (Mylan Institutional LLC), PALONOSETRON (Qilu Pharmaceutical), PALONOSETRON HYDROCHLORIDE (Sagent Pharmaceuticals), PALONOSETRON HYDROCHLORIDE (Sagent Pharmaceuticals), PALONOSETRON HYDROCHLORIDE (Sandoz), PALONOSETRON HYDROCHLORIDE (Sandoz), PALONOSETRON HYDROCHLORIDE (Teva Parenteral Medicines), PALONOSETRON HYDROCHLORIDE (Virtus Pharmaceuticals), PALONOSETRON HYDROCHLORIDE (Cipla USA)

Formula

C19H24N2O. HCl

Exact mass

332.1655

Mol weight

332.8676

Structure

Simcomp

Class

Gastrointestinal agent
DG01489  5-HT3-receptor antagonist
DG01762  Antiemetic
Metabolizing enzyme substrate
DG01892  CYP1A2 substrate
DG01644  CYP2D6 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Therapeutic category:

2391

ATC code:

A04AA05

Chemical structure group:

DG00064

Product (DG00064):

D05343<JP/US>

Product (mixture):

D10572<US>

Efficacy

Anti-emetic, Serotonin 5-HT3 receptor antagonist

Target

HTR3 [HSA:3359 9177 170572 200909 285242] [KO:K04819]

Pathway

hsa04726

Serotonergic synapse

Metabolism

Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AA Serotonin (5HT3) antagonists
     A04AA05 Palonosetron
      D05343  Palonosetron hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Antiemetics
  Emetogenic Therapy Adjuncts
   Palonosetron
    D05343  Palonosetron hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2391  Antiemetics
     D05343  Palonosetron hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Gastrointestinal agent
  DG01489  5-HT3-receptor antagonist
   DG00064  Palonosetron
    D05343  Palonosetron hydrochloride
  DG01762  Antiemetic
   DG00064  Palonosetron
    D05343  Palonosetron hydrochloride
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00064  Palonosetron
    D05343  Palonosetron hydrochloride
  DG01644  CYP2D6 substrate
   DG00064  Palonosetron
    D05343  Palonosetron hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00064  Palonosetron
     D05343  Palonosetron hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
  Ligand-gated ion channels
   Serotonin
    HTR3
     D05343  Palonosetron hydrochloride (JAN/USP) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D05343
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D05343
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D05343
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D05343
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D05343
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D05343
Drug groups [BR:br08330]
Gastrointestinal agent
  DG01489  5-HT3-receptor antagonist
   DG00064  Palonosetron
  DG01762  Antiemetic
   DG00064  Palonosetron
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00064  Palonosetron
  DG01644  CYP2D6 substrate
   DG00064  Palonosetron
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00064  Palonosetron

Other DBs

CAS:	135729-62-3

PubChem:

47207029

ChEBI:

85157

LigandBox:

D05343

KCF data

ATOM        23
            1   N1y N    31.1604  -19.2289
            2   C5x C    32.5639  -19.2289
            3   C8y C    33.2656  -18.0359
            4   C8y C    32.5639  -16.8429
            5   C1y C    31.1604  -16.8427
            6   C1x C    30.4586  -17.9657
            7   C8y C    33.2656  -15.6499
            8   C1x C    32.5639  -14.3868
            9   C1x C    31.2306  -14.3868
            10  C1x C    30.5288  -15.5798
            11  C8x C    34.6691  -18.0359
            12  C8x C    35.3709  -16.8429
            13  C8x C    34.6691  -15.6499
            14  O5x O    33.2656  -20.4218
            15  C1y C    29.6867  -18.6675
            16  C1x C    29.0551  -19.6499
            17  N1y N    27.5814  -18.8078
            18  C1x C    27.5814  -17.5447
            19  C1x C    26.0376  -19.5797
            20  C1y C    28.3534  -17.7552
            21  C1x C    28.3534  -16.7727
            22  C1x C    26.7393  -18.4569
            23  X   Cl   37.2656  -18.5271
BOND        26
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    3  11 1
            13   11  12 2
            14   12  13 1
            15   13   7 2
            16    2  14 2
            17   16  17 1
            18   16  15 1
            19   17  18 1
            20   17  19 1
            21   15  20 1
            22   18  21 1
            23   19  22 1
            24   20  21 1
            25   20  22 1
            26   15   1 1 #Down