Entry

D05374                      Drug

Name

Paroxetine hydrochloride (USP);
Paxil (TN)

Product

Generic

PAROXETINE (A-S Medication Solutions), PAROXETINE (DIRECT RX), PAROXETINE (DirectRX), PAROXETINE (RPK Pharmaceuticals), PAROXETINE (Westminster Pharmaceuticals), PAROXETINE (A-S Medication Solutions), PAROXETINE (A-S Medication Solutions), PAROXETINE (A-S Medication Solutions), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Apotex Corp.), PAROXETINE HYDROCHLORIDE (Bryant Ranch Prepack), PAROXETINE (Cardinal Health), PAROXETINE (Golden State Medical Supply), PAROXETINE HYDROCHLORIDE (Lannett Company), PAROXETINE (Major Pharmaceuticals), PAROXETINE (NuCare Pharmaceuticals), PAROXETINE (NuCare Pharmaceuticals), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK)

Formula

C19H20FNO3. HCl

Exact mass

365.1194

Mol weight

365.8263

Structure

Simcomp

Class

Neuropsychiatric agent
DG01659  Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
DG01644  CYP2D6 substrate
Metabolizing enzyme inhibitor
DG01645  CYP2D6 inhibitor

Remark

ATC code:

N06AB05

Chemical structure group:

DG00944

Product (DG00944):

D02260<JP/US> D05374<US> D05375<US>

Efficacy

Antidepressant, Selective serotonin reuptake inhibitor (SSRI)

Disease

Major depressive disorder [DS:H01646]
Obsessive compulsive disorder [DS:H01450]
Panic disorder [DS:H01664]
Social anxiety disorder [DS:H01670]
Generalized anxiety disorder [DS:H01662]

Comment

Fluoxetine derivative

Target

SLC6A4 (HTT) [HSA:6532] [KO:K05037]

Pathway

hsa04726

Serotonergic synapse

Metabolism

Enzyme: CYP2D6 [HSA:1565]

Interaction

CYP inhibition: CYP2D6 [HSA:1565]

Structure map

map07027

Antidepressants

map07234

Neurotransmitter transporter inhibitors

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB05 Paroxetine
      D05374  Paroxetine hydrochloride (USP) <US>
USP drug classification [BR:br08302]
Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D05374  Paroxetine hydrochloride (USP)
Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D05374  Paroxetine hydrochloride (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   DG00944  Paroxetine
    D05374  Paroxetine hydrochloride
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00944  Paroxetine
    D05374  Paroxetine hydrochloride
Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00944  Paroxetine
    D05374  Paroxetine hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   D05374  Paroxetine hydrochloride
Target-based classification of drugs [BR:br08310]
Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D05374  Paroxetine hydrochloride (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D05374
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D05374
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   DG00944  Paroxetine
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00944  Paroxetine
Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00944  Paroxetine

Other DBs

CAS:	78246-49-8

PubChem:

47207050

ChEBI:

7944

LigandBox:

D05374

NIKKAJI:

J345.197F

KCF data

ATOM        25
            1   C1y C    25.2966  -20.5661
            2   C1y C    24.0856  -21.2622
            3   C8y C    25.3023  -19.1620
            4   C1x C    26.5074  -21.2622
            5   C1b C    22.8746  -20.5661
            6   C1x C    24.0856  -22.6663
            7   C8x C    26.5133  -18.4659
            8   C8x C    24.0913  -18.4659
            9   C1x C    26.5074  -22.6663
            10  O2a O    21.6576  -21.2622
            11  N1x N    25.2966  -23.3626
            12  C8x C    26.5133  -17.0677
            13  C8x C    24.0913  -17.0619
            14  C8y C    20.4465  -20.5601
            15  C8y C    25.3023  -16.3657
            16  C8x C    20.4525  -19.1679
            17  C8x C    19.2415  -21.2681
            18  X   F    25.2381  -14.9675
            19  C8y C    19.2472  -18.4659
            20  C8x C    18.0305  -20.5661
            21  C8y C    18.0305  -19.1679
            22  O2x O    18.9607  -17.0911
            23  O2x O    16.9891  -18.2260
            24  C1x C    17.5624  -16.9391
            25  X   Cl   29.5912  -22.1540
BOND        27
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1 #Up
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 2
            13   10  14 1
            14   12  15 2
            15   14  16 2
            16   14  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 2
            20   19  21 2
            21   19  22 1
            22   21  23 1
            23   22  24 1
            24    9  11 1
            25   13  15 1
            26   20  21 1
            27   23  24 1