Entry

D05597                      Drug

Name

Prasugrel hydrochloride (JAN/USAN);
Effient (TN)

Product

EFFIENT (Cosette Pharmaceuticals), EFFIENT (Daiichi Sankyo)

Generic

PRASUGREL (A-S Medication Solutions), PRASUGREL (A-S Medication Solutions), PRASUGREL (Accord Healthcare), PRASUGREL (Amneal Pharmaceuticals LLC), PRASUGREL (Apotex Corp.), PRASUGREL (Ascend Laboratories), PRASUGREL (Aurobindo Pharma Limited), PRASUGREL (Golden State Medical Supply), PRASUGREL (Mylan Pharmaceuticals), PRASUGREL (Panacea Biotec Limited)

Formula

C20H20FNO3S. HCl

Exact mass

409.0915

Mol weight

409.902

Structure

Class

Blood modifier agent
DG01950  Antithrombotic agent
  DG01712  Antiplatelet agent
   DG01808  Thienopyridine
DG01809  P2Y12 receptor antagonist
  DG01808  Thienopyridine
Metabolizing enzyme substrate
DG02919  CYP2B6 substrate
DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02892  CYP2B6 inhibitor

Remark

Therapeutic category:

3399

ATC code:

B01AC22

Product:

D05597<JP/US>

Efficacy

Platelet aggregation inhibitor, Purinergic receptor P2Y12 antagonist

Disease

Unstable angina [DS:H01632]
Myocardial infarction [DS:H01730]

Comment

Thienopyridine derivative

Target

P2RY12 [HSA:64805] [KO:K04298]

Pathway

hsa04611

Platelet activation

Metabolism

Enzyme: CYP3A [HSA:1576 1577 1551], CYP2B6 [HSA:1555]

Interaction

CYP inhibition: CYP2B6 [HSA:1555]

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC22 Prasugrel
      D05597  Prasugrel hydrochloride (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
Blood Products and Modifiers
  Platelet Modifying Agents
   Adenosine Diphosphate P2Y12
    Prasugrel
     D05597  Prasugrel hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D05597  Prasugrel hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
Blood modifier agent
  DG01950  Antithrombotic agent
   DG01712  Antiplatelet agent
    DG01808  Thienopyridine
     D05597  Prasugrel hydrochloride
  DG01809  P2Y12 receptor antagonist
   DG01808  Thienopyridine
    D05597  Prasugrel hydrochloride
Metabolizing enzyme substrate
  DG02919  CYP2B6 substrate
   D05597  Prasugrel hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   D05597  Prasugrel hydrochloride
Metabolizing enzyme inhibitor
  DG02892  CYP2B6 inhibitor
   D05597  Prasugrel hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Purine / pyrimidine
    P2RY12
     D05597  Prasugrel hydrochloride (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D05597
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D05597
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D05597
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D05597
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D05597
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D05597

Other DBs

CAS:	389574-19-0

PubChem:

47207260

ChEBI:

87697

LigandBox:

D05597

KCF data

ATOM        27
            1   N1y N    17.0100  -15.7500
            2   C1x C    17.0100  -14.3500
            3   C1x C    18.2000  -13.6500
            4   C8y C    19.4600  -14.3500
            5   C8y C    19.4600  -15.7500
            6   C1x C    18.2000  -16.4500
            7   S2x S    20.7900  -13.9300
            8   C8y C    21.5600  -15.0500
            9   C8x C    20.7900  -16.1700
            10  O7a O    22.9600  -15.0500
            11  C7a C    23.6600  -13.8600
            12  C1a C    25.0600  -13.8600
            13  O6a O    22.9600  -12.6700
            14  C1c C    15.8200  -16.4500
            15  C8y C    14.6300  -15.7500
            16  C5a C    15.8200  -17.8500
            17  O5a O    17.0100  -18.5500
            18  C1y C    14.6300  -18.5500
            19  C8y C    14.6300  -14.3500
            20  C8x C    13.3700  -13.6500
            21  C8x C    12.1800  -14.3500
            22  C8x C    12.1800  -15.7500
            23  C8x C    13.3700  -16.4500
            24  C1x C    13.2300  -18.5500
            25  C1x C    13.9300  -19.7400
            26  X   F    15.8200  -13.6500
            27  X   Cl   24.7800  -18.0600
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    5   9 1
            11    8  10 1
            12   10  11 1
            13   11  12 1
            14   11  13 2
            15    1  14 1
            16   14  15 1
            17   14  16 1
            18   16  17 2
            19   16  18 1
            20   15  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   15  23 1
            26   18  24 1
            27   24  25 1
            28   25  18 1
            29   19  26 1