| Entry |
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| Name | Hydrocortisone aceponate (INN); Efficort (TN) | ||||||
| Formula | C26H36O7 | ||||||
| Exact mass | 460.2461 | ||||||
| Mol weight | 460.5598 | ||||||
| Structure |  | ||||||
| Simcomp | |||||||
| Class | Anti-inflammatory DG01955 Corticosteroid DG02068 Glucocorticoid Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate | ||||||
| Remark |
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| Efficacy | Anti-inflammatory, Glucocorticoid receptor agonist | ||||||
| Target | NR3C1 (GR) [HSA:2908] [KO:K05771] | ||||||
| Pathway |
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| Metabolism | Enzyme: CYP3A [HSA:1576 1577 1551] | ||||||
| Interaction | |||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] A ALIMENTARY TRACT AND METABOLISM A01 STOMATOLOGICAL PREPARATIONS A01A STOMATOLOGICAL PREPARATIONS A01AC Corticosteroids for local oral treatment A01AC03 Hydrocortisone D06876 Hydrocortisone aceponate (INN) A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS A07E INTESTINAL ANTIINFLAMMATORY AGENTS A07EA Corticosteroids acting locally A07EA02 Hydrocortisone D06876 Hydrocortisone aceponate (INN) C CARDIOVASCULAR SYSTEM C05 VASOPROTECTIVES C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE C05AA Corticosteroids C05AA01 Hydrocortisone D06876 Hydrocortisone aceponate (INN) D DERMATOLOGICALS D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS D07A CORTICOSTEROIDS, PLAIN D07AA Corticosteroids, weak (group I) D07AA02 Hydrocortisone D06876 Hydrocortisone aceponate (INN) D07AC Corticosteroids, potent (group III) D07AC16 Hydrocortisone aceponate D06876 Hydrocortisone aceponate (INN) D07X CORTICOSTEROIDS, OTHER COMBINATIONS D07XA Corticosteroids, weak, other combinations D07XA01 Hydrocortisone D06876 Hydrocortisone aceponate (INN) H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS H02 CORTICOSTEROIDS FOR SYSTEMIC USE H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN H02AB Glucocorticoids H02AB09 Hydrocortisone D06876 Hydrocortisone aceponate (INN) S SENSORY ORGANS S01 OPHTHALMOLOGICALS S01B ANTIINFLAMMATORY AGENTS S01BA Corticosteroids, plain S01BA02 Hydrocortisone D06876 Hydrocortisone aceponate (INN) S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION S01CB Corticosteroids/antiinfectives/mydriatics in combination S01CB03 Hydrocortisone D06876 Hydrocortisone aceponate (INN) S02 OTOLOGICALS S02B CORTICOSTEROIDS S02BA Corticosteroids S02BA01 Hydrocortisone D06876 Hydrocortisone aceponate (INN) Animal drugs in Japan [BR:br08331] 95 Agents for external use 953 Analgesics, anti-itchings, astringents and antiinflammatory agents 9537 Hormone preparations for external use D06876 Hydrocortisone aceponate Drug groups [BR:br08330] Anti-inflammatory DG01955 Corticosteroid DG02068 Glucocorticoid DG00012 Hydrocortisone D06876 Hydrocortisone aceponate Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG00012 Hydrocortisone D06876 Hydrocortisone aceponate Target-based classification of drugs [BR:br08310] Nuclear receptors Estrogen like receptors 3-Ketosteroid receptor NR3C1 (GR) D06876 Hydrocortisone aceponate (INN) Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D06876 Drug groups [BR:br08330] Anti-inflammatory DG01955 Corticosteroid DG02068 Glucocorticoid DG00012 Hydrocortisone Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG00012 Hydrocortisone | ||||||
| Other DBs |
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| KCF data | ATOM 33 1 C1y C 28.7000 -19.1100 2 C1y C 27.5100 -19.8100 3 C1z C 28.7000 -17.7800 4 C1x C 31.0100 -19.1100 5 C1y C 26.3200 -19.1100 6 C1x C 27.5100 -21.1400 7 C1z C 29.8900 -17.0800 8 C1x C 27.5100 -17.0800 9 C1a C 28.7000 -16.3800 10 C1x C 31.0100 -17.7800 11 C1z C 25.1300 -19.8100 12 C1y C 26.3200 -17.7800 13 C1x C 26.3200 -21.8400 14 C5a C 29.8900 -15.6800 15 C2y C 25.1300 -21.1400 16 C1x C 23.9400 -19.1100 17 C1a C 25.1300 -18.4100 18 O1a O 25.1300 -17.0800 19 C1b C 31.0800 -14.9800 20 O5a O 28.7000 -14.9800 21 C2x C 23.9400 -21.8400 22 C1x C 22.7500 -19.8100 23 C5x C 22.7500 -21.1400 24 O5x O 21.5600 -21.8400 25 O7a O 31.2200 -16.7300 26 C7a C 32.3477 -17.5596 27 O6a O 32.3452 -18.9700 28 C1b C 33.5872 -16.9341 29 C1a C 34.7700 -17.7088 30 O7a O 31.0686 -13.5800 31 C7a C 32.2837 -12.8652 32 C1a C 33.4977 -13.5529 33 O6a O 32.2723 -11.4800 BOND 36 1 1 2 1 2 1 3 1 3 1 4 1 4 2 5 1 5 2 6 1 6 3 7 1 7 3 8 1 8 3 9 1 #Up 9 4 10 1 10 5 11 1 11 5 12 1 12 6 13 1 13 7 14 1 #Up 14 11 15 1 15 11 16 1 16 11 17 1 #Up 17 12 18 1 #Up 18 14 19 1 19 14 20 2 20 15 21 2 21 16 22 1 22 21 23 1 23 23 24 2 24 7 10 1 25 8 12 1 26 13 15 1 27 22 23 1 28 7 25 1 #Down 29 25 26 1 30 26 27 2 31 26 28 1 32 28 29 1 33 19 30 1 34 30 31 1 35 31 32 1 36 31 33 2 |