Carglumic acid


Entry
D07130                      Drug                                   
Name
Carglumic acid (JAN/USAN/INN);
Carbaglu (TN)
Product
CARBAGLU (Recordati Rare Diseases)
  Generic
CARGLUMIC ACID (Eton Pharmaceuticals), CARGLUMIC ACID (Navinta LLC)
Formula
C6H10N2O5
Exact mass
190.059
Mol weight
190.154
Structure
Simcomp
Remark
Same as: C05829
Therapeutic category: 3999
ATC code: A16AA05
Product: D07130<JP/US>
Efficacy
Antihyperammonemic
  Disease
NAGS deficiency [DS:H01032]
Comment
Treatment of hyperammonaemia due to N-acetylglutamate synthase (NAGS) deficiency
Target
CPS1 [HSA:1373] [KO:K01948]
  Network
N10011  CPS1 activator for deficient NAGS
  Pathway
hsa00220  Arginine biosynthesis
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00910  Nitrogen metabolism
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AA Amino acids and derivatives
     A16AA05 Carglumic acid
      D07130  Carglumic acid (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Electrolytes/Minerals/Metals/Vitamins
  Electrolyte/Mineral Replacement
   Carglumic Acid
    D07130  Carglumic acid (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D07130  Carglumic acid (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Ligases (EC6)
   Carbamoyl-phosphate synthase
    CPS1
     D07130  Carglumic acid (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D07130
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D07130
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D07130
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D07130
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D07130
Other DBs
CAS: 1188-38-1
PubChem: 51091469
ChEBI: 71028
LigandBox: D07130
KCF data

ATOM        13
            1   O6a O    14.9813  -16.8715
            2   C6a C    16.1938  -17.5716
            3   C1b C    17.4064  -16.8715
            4   C1b C    18.6189  -17.5716
            5   C1c C    19.8314  -16.8715
            6   C6a C    21.0440  -17.5716
            7   O6a O    22.2565  -16.8715
            8   O6a O    16.1938  -18.9715
            9   O6a O    21.0440  -18.9714
            10  N1b N    19.8314  -15.4715
            11  C5a C    18.6000  -14.7699
            12  O5a O    18.6017  -13.3698
            13  N1a N    17.4047  -15.4638
BOND        12
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     2   8 2
            8     6   9 2
            9     5  10 1 #Down
            10   10  11 1
            11   11  12 2
            12   11  13 1