Benzydamine

Entry

D07516                      Drug

Name

Benzydamine (INN);
Apo-Benzydamine (TN)

Formula

C19H23N3O

Exact mass

309.1841

Mol weight

309.4054

Structure

Simcomp

Class

Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)

Remark

ATC code:

A01AD02 G02CC03 M01AX07 M02AA05 R02AX03

Chemical structure group:

DG00014

Efficacy

Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor

Comment

Benzimidazole derivative
non-steroidal anti-inflammatory drug (NSAID)

Target

PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
ALOX5 [HSA:240] [KO:K00461]

Pathway

hsa00590

Arachidonic acid metabolism

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AD Other agents for local oral treatment
     A01AD02 Benzydamine (except lozenges)
      D07516  Benzydamine (INN)
G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC03 Benzydamine
      D07516  Benzydamine (INN)
M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AX Other antiinflammatory and antirheumatic agents, non-steroids
     M01AX07 Benzydamine
      D07516  Benzydamine (INN)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA05 Benzydamine
      D07516  Benzydamine (INN)
R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AX Other throat preparetions
     R02AX03 Benzydamine (only lozenges)
      D07516  Benzydamine (INN)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG00014  Benzydamine
    D07516  Benzydamine
Target-based classification of drugs [BR:br08310]
Enzymes
  Oxidoreductases (EC1)
   Dioxygenases
    ALOX5
     D07516  Benzydamine (INN)
   Prostaglandin synthase
    PTGS1 (COX1)
     D07516  Benzydamine (INN)
    PTGS2 (COX2)
     D07516  Benzydamine (INN)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG00014  Benzydamine

Other DBs

CAS:

642-72-8

PubChem:

51091839

ChEBI:

94563

LigandBox:

D07516

NIKKAJI:

J7.060B

KCF data

ATOM        23
            1   C8x C    20.5100  -19.4600
            2   C8x C    19.2500  -18.7600
            3   C8x C    19.2500  -17.3600
            4   C8x C    20.5100  -16.6600
            5   C8y C    21.7000  -18.7600
            6   C8y C    21.7000  -17.3600
            7   N4y N    23.0300  -16.8700
            8   N5x N    23.8700  -18.0600
            9   C8y C    23.0300  -19.1800
            10  C1b C    23.8700  -15.7500
            11  C8y C    25.2700  -15.7500
            12  C8x C    25.9700  -17.0100
            13  C8x C    27.3700  -17.0100
            14  C8x C    28.0700  -15.7500
            15  C8x C    27.3700  -14.5600
            16  C8x C    25.9700  -14.5600
            17  O2a O    23.0300  -20.5800
            18  C1b C    24.2200  -21.2800
            19  C1b C    25.4800  -20.5800
            20  C1b C    26.6000  -21.2800
            21  N1c N    27.8600  -20.5800
            22  C1a C    29.0500  -21.2800
            23  C1a C    27.8600  -19.1800
BOND        25
            1     5   1 1
            2     1   2 2
            3    10   7 1
            4     2   3 1
            5     3   4 2
            6     5   6 2
            7    10  11 1
            8     6   7 1
            9     7   8 1
            10    8   9 2
            11    9   5 1
            12    4   6 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  11 1
            19    9  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   21  23 1