Cefixime

Entry

D07640                      Drug

Name

Cefixime (USP);
Cefixime hydrate (JP18);
Cefixime trihydrate;
Oroken (TN);
Suprax (TN)

Product

SUPRAX (Lupin Pharmaceuticals)

Generic

CEFIXIME (Ascend Laboratories), CEFIXIME (Aurobindo Pharma Limited), CEFIXIME (Belcher Pharmaceuticals), CEFIXIME (Belcher Pharmaceuticals), CEFIXIME (Dr. Reddy's Laboratories), CEFIXIME (Lupin Pharmaceuticals), SUPRAX (Lupin Pharmaceuticals), CEFIXIME (NorthStar RxLLC), SUPRAX (PharmPak), CEFIXIME (REMEDYREPACK), CEFIXIME (REMEDYREPACK)

Formula

C16H15N5O7S2. 3H2O

Exact mass

507.073

Mol weight

507.4954

Structure

Simcomp

Class

Antibacterial
DG01710  beta-Lactam antibiotic
  DG01714  Cephalosporin skeleton group
   DG01488  Cephem
DG01776  Third-generation cephalosporin
DG01804  Oxyimino beta-lactam

Remark

Therapeutic category:

6132

ATC code:

J01DD08

Chemical structure group:

DG00577

Product (DG00577):

D07640<JP/US>

Efficacy

Antibacterial, Cell wall biosynthesis inhibitor

Disease

Uncomplicated urinary tract infection [DS:H01176]
Uncomplicated gonorrhea [DS:H00315]

Target

penicillin binding protein

Pathway

ko00550

Peptidoglycan biosynthesis

Interaction

Structure map

map07013

Cephalosporins - oral agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DD Third-generation cephalosporins
     J01DD08 Cefixime
      D07640  Cefixime (USP) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
  Beta-lactam, Cephalosporins
   Cefixime
    D07640  Cefixime (USP)
Therapeutic category of drugs in Japan [BR:br08301]
6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6132  Cephem antibioitics
     D07640  Cefixime (USP); Cefixime hydrate (JP18)
Drug groups [BR:br08330]
Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00577  Cefixime
      D07640  Cefixime
  DG01776  Third-generation cephalosporin
   DG00577  Cefixime
    D07640  Cefixime
  DG01804  Oxyimino beta-lactam
   DG00577  Cefixime
    D07640  Cefixime
Drug classes [BR:br08332]
Antibacterial
  DG01488  Cephem
   D07640  Cefixime
Antimicrobials [BR:br08307]
Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Third-generation cephalosporin
    D07640  Cefixime (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D07640  Cefixime hydrate
  D07640  Cefixime capsules
  D07640  Cefixime fine granules
Drug groups [BR:br08330]
Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00577  Cefixime
  DG01776  Third-generation cephalosporin
   DG00577  Cefixime
  DG01804  Oxyimino beta-lactam
   DG00577  Cefixime
Antimicrobials abbreviations [BR:br08327]
Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Third-generation cephalosporin
    DG00577  Cefixime

Other DBs

CAS:	125110-14-7

PubChem:

51091944

LigandBox:

D07640

KCF data

ATOM        33
            1   C1y C    26.2500  -18.9700
            2   N1y N    26.2500  -20.3700
            3   C2y C    27.4400  -21.0700
            4   C2y C    28.6300  -20.3700
            5   C1x C    28.6300  -18.9700
            6   S2x S    27.4400  -18.2700
            7   C1y C    24.8500  -18.9700
            8   C5x C    24.8500  -20.3700
            9   N1b N    23.6600  -18.2700
            10  C5a C    22.4700  -18.9700
            11  O5a O    22.4700  -20.3700
            12  O5x O    23.6600  -21.0700
            13  C2c C    21.2800  -18.2700
            14  C2b C    29.8900  -21.0700
            15  C8y C    20.0200  -18.9700
            16  C2a C    31.0800  -20.3700
            17  C8x C    18.9000  -18.1300
            18  S2x S    17.7800  -18.9700
            19  C8y C    18.2000  -20.3700
            20  N5x N    19.6000  -20.3000
            21  N2b N    21.2800  -16.8700
            22  C6a C    27.4400  -22.4700
            23  O6a O    26.2500  -23.1700
            24  O6a O    28.7000  -23.1700
            25  N1a N    17.2900  -21.4900
            26  O2a O    22.4700  -16.1700
            27  C1b C    22.4700  -14.7700
            28  C6a C    23.6600  -14.0700
            29  O6a O    24.8500  -14.7700
            30  O6a O    23.6600  -12.6700
            31  O0  O    35.1400  -14.8400
            32  O0  O    35.3500  -17.9200
            33  O0  O    35.2100  -20.7200
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16   13  15 1
            17   14  16 2
            18   15  17 2
            19   17  18 1
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23   13  21 2
            24    3  22 1
            25   22  23 2
            26   22  24 1
            27   19  25 1
            28   21  26 1
            29   26  27 1
            30   27  28 1
            31   28  29 2
            32   28  30 1