Bupropion hydrobromide


Entry
D07938                      Drug                                   
Name
Bupropion hydrobromide (USAN);
Aplenzin (TN)
Product
APLENZIN (Bausch Health US)
Formula
C13H18ClNO. HBr
Exact mass
319.0339
Mol weight
320.6531
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03059  Noradrenalin and dopamine reuptake inhibitor (NDRI)
Remark
ATC code: N06AX12
Chemical structure group: DG00957
Product (DG00957): D00817<US> D07938<US>
Product (mixture): D10751<US>
Efficacy
Antidepressant, Noradrenalin and dopamine reuptake inhibitor
  Disease
Major depressive disorder [DS:H01646]
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX12 Bupropion
      D07938  Bupropion hydrobromide (USAN) <US>
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Smoking Cessation Agents
   Bupropion
    D07938  Bupropion hydrobromide (USAN)
 Antidepressants
  Antidepressants, Other
   Bupropion
    D07938  Bupropion hydrobromide (USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03059  Noradrenalin and dopamine reuptake inhibitor (NDRI)
   DG00957  Bupropion
    D07938  Bupropion hydrobromide
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D07938  Bupropion hydrobromide (USAN) <US>
    SLC6A3 (DAT1)
     D07938  Bupropion hydrobromide (USAN) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03059  Noradrenalin and dopamine reuptake inhibitor (NDRI)
   DG00957  Bupropion
Other DBs
CAS: 905818-69-1
PubChem: 96024633
LigandBox: D07938
KCF data

ATOM        17
            1   C8y C    16.3800  -16.1700
            2   C8x C    16.3800  -17.5700
            3   C8x C    15.1200  -18.2700
            4   C8x C    13.9300  -17.5700
            5   C8y C    13.9300  -16.1700
            6   C8x C    15.1200  -15.4700
            7   X   Cl   12.6700  -15.4700
            8   C5a C    17.5700  -15.4700
            9   C1c C    18.7600  -16.1700
            10  O5a O    17.5700  -14.0700
            11  N1b N    19.9500  -15.4700
            12  C1a C    18.7600  -17.5700
            13  C1d C    21.1400  -16.1700
            14  C1a C    22.3300  -15.4700
            15  C1a C    21.1400  -17.5700
            16  C1a C    22.4000  -16.8000
            17  X   Br   25.9700  -16.8700
BOND        16
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     1   8 1
            9     8   9 1
            10    8  10 2
            11    9  11 1
            12    9  12 1
            13   11  13 1
            14   13  14 1
            15   13  15 1
            16   13  16 1