Entry

D08118                      Drug

Name

Levocetirizine dihydrochloride (USP);
Levocetirizine hydrochloride (JAN);
Xyzal (TN)

Product

Generic

LEVOCETIRIZINE DIHYDROCHLORIDE (A-S Medication Solutions), LEVOCETIRIZINE DIHYDROCHLORIDE (A-S Medication Solutions), LEVOCETIRIZINE DIHYDROCHLORIDE (A-S Medication Solutions), LEVOCETIRIZINE DIHYDROCHLORIDE (AvKARE), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Camber Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Camber Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Denton Pharma), LEVOCETIRIZINE DIHYDROCHLORIDE (Dr.Reddy's laboratories), LEVOCETIRIZINE DIHYDROCHLORIDE (Glenmark Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Lannett Company), LEVOCETIRIZINE DIHYDROCHLORIDE (Macleods Pharmaceuticals Limited), LEVOCETIRIZINE DIHYDROCHLORIDE (Marlex Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Micro Labs Limited), LEVOCETIRIZINE DIHYDROCHLORIDE (NuCare Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (NuCare Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (PD-Rx Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (PD-Rx Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Padagis Israel Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Preferred Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Preferred Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Proficient Rx LP), LEVOCETIRIZINE DIHYDROCHLORIDE (Proficient Rx LP), LEVOCETIRIZINE DIHYDROCHLORIDE (Proficient Rx LP), LEVOCETIRIZINE DIHYDROCHLORIDE (Proficient Rx LP), LEVOCETIRIZINE DIHYDROCHLORIDE (Proficient Rx LP), LEVOCETIRIZINE DIHYDROCHLORIDE (Proficient Rx LP), LEVOCETIRIZINE DIHYDROCHLORIDE (REMEDYREPACK), LEVOCETIRIZINE DIHYDROCHLORIDE (REMEDYREPACK), LEVOCETIRIZINE DIHYDROCHLORIDE (REMEDYREPACK), LEVOCETIRIZINE DIHYDROCHLORIDE (ScieGen Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), LEVOCETIRIZINE DIHYDROCHLORIDE (Teva Pharmaceuticals USA), LEVOCETIRIZINE DIHYDROCHLORIDE (Vensun Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Westminster Pharmaceuticals)

Formula

C21H25ClN2O3. 2HCl

Exact mass

460.1087

Mol weight

461.8097

Structure

Simcomp

Class

Anti-allergic agent
DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Metabolizing enzyme substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Therapeutic category:

4490

ATC code:

R06AE09

Chemical structure group:

DG01108

Product (DG01108):

D08118<JP/US>

Efficacy

Antiallergic, H1 receptor antagonist

Disease

Allergic rhinitis [DS:H01360]

Target

HRH1 [HSA:3269] [KO:K04149]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04750

Inflammatory mediator regulation of TRP channels

Metabolism

Enzyme: CYP3A4 [HSA:1576]

Interaction

Structure map

map07212

Histamine H1 receptor antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AE Piperazine derivatives
     R06AE09 Levocetirizine
      D08118  Levocetirizine dihydrochloride (USP) <JP/US>
USP drug classification [BR:br08302]
Respiratory Tract/Pulmonary Agents
  Antihistamines
   Histamine (H1) Receptor Antagonists, Mildly/Non-sedating
    Levocetirizine
     D08118  Levocetirizine dihydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D08118  Levocetirizine dihydrochloride (USP); Levocetirizine hydrochloride (JAN)
Drug groups [BR:br08330]
Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01108  Levocetirizine
     D08118  Levocetirizine dihydrochloride
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG01108  Levocetirizine
     D08118  Levocetirizine dihydrochloride
Drug classes [BR:br08332]
Anti-allergic agent
  DG01482  Histamine receptor H1 antagonist
   D08118  Levocetirizine dihydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D08118  Levocetirizine dihydrochloride (USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D08118
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D08118
Rx-to-OTC switch list in the USA [br08315.html]
D08118
Drug groups [BR:br08330]
Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01108  Levocetirizine
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG01108  Levocetirizine

Other DBs

CAS:	130018-87-0

PubChem:

96024808

LigandBox:

D08118

KCF data

ATOM        29
            1   C8x C    21.4819  -20.8517
            2   C8y C    21.4819  -22.2511
            3   C8x C    22.7413  -22.9508
            4   C8x C    23.9309  -22.2511
            5   C8y C    23.9309  -20.8517
            6   C8x C    22.7413  -20.1519
            7   C8x C    26.3799  -22.2511
            8   C8y C    26.3799  -20.8517
            9   C1c C    25.1204  -20.1519
            10  C8x C    27.5694  -22.9508
            11  C8x C    28.7589  -22.2511
            12  C8x C    28.7589  -20.8517
            13  C8x C    27.5694  -20.1519
            14  N1y N    25.1204  -18.7525
            15  C1x C    26.3799  -18.0528
            16  C1x C    26.3799  -16.6534
            17  N1y N    25.1204  -15.8837
            18  C1x C    23.9309  -16.6534
            19  C1x C    23.9309  -18.0528
            20  X   Cl   20.2923  -22.9508
            21  C1b C    25.1204  -14.4843
            22  C1b C    26.3799  -13.7845
            23  O2a O    27.5694  -14.4843
            24  C1b C    28.7589  -13.8545
            25  C6a C    29.9484  -14.4843
            26  O6a O    31.1379  -13.8545
            27  O6a O    29.9484  -15.9537
            28  X   Cl   31.9074  -18.9624
            29  X   Cl   31.8376  -21.1315
BOND        29
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     9   8 1 #Down
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   14  19 1
            22    2  20 1
            23   17  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   25  27 2