Viloxazine

Entry

D08673                      Drug

Name

Viloxazine (INN)

Formula

C13H19NO3

Exact mass

237.1365

Mol weight

237.2949

Structure

Simcomp

Class

Neuropsychiatric agent
DG03085  Selective norepinephrine reuptake inhibitor (NRI)
Metabolizing enzyme substrate
DG01644  CYP2D6 substrate
DG02924  UGT substrate
  DG03188  UGT1A9 substrate
  DG03187  UGT2B15 substrate

Remark

ATC code:

N06AX09

Chemical structure group:

DG00956

Product (DG00956):

D02572<US>

Efficacy

Antidepressant, Selective noradrenaline reuptake inhibitor (NRI)

Target

SLC6A2 (NAT1) [HSA:6530] [KO:K05035]

Pathway

hsa04721

Synaptic vesicle cycle

Metabolism

Enzyme: CYP2D6 [HSA:1565], UGT1A9 [HSA:54600], UGT2B15 [HSA:7366]

Interaction

Structure map

map07027

Antidepressants

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX09 Viloxazine
      D08673  Viloxazine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG03085  Selective norepinephrine reuptake inhibitor (NRI)
   DG00956  Viloxazine
    D08673  Viloxazine
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00956  Viloxazine
    D08673  Viloxazine
  DG02924  UGT substrate
   DG03188  UGT1A9 substrate
    DG00956  Viloxazine
     D08673  Viloxazine
   DG03187  UGT2B15 substrate
    DG00956  Viloxazine
     D08673  Viloxazine
Target-based classification of drugs [BR:br08310]
Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D08673  Viloxazine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D08673
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG03085  Selective norepinephrine reuptake inhibitor (NRI)
   DG00956  Viloxazine
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00956  Viloxazine
  DG02924  UGT substrate
   DG03188  UGT1A9 substrate
    DG00956  Viloxazine
   DG03187  UGT2B15 substrate
    DG00956  Viloxazine

Other DBs

CAS:	46817-91-8

PubChem:

96025356

LigandBox:

D08673

NIKKAJI:

J16.881E

KCF data

ATOM        17
            1   C8x C    19.8800  -17.5700
            2   C8x C    19.8800  -16.1700
            3   C8x C    21.0700  -15.4700
            4   C8y C    22.3300  -16.1700
            5   C8y C    22.3300  -17.5700
            6   C8x C    21.0700  -18.2700
            7   O2a O    23.5200  -18.2700
            8   C1b C    24.7800  -17.5700
            9   C1y C    25.9700  -18.2700
            10  O2a O    23.5200  -15.4700
            11  C1b C    24.7800  -16.1700
            12  C1a C    25.9700  -15.4700
            13  O2x O    27.1600  -17.5700
            14  C1x C    28.4200  -18.2700
            15  C1x C    28.4200  -19.6700
            16  N1x N    27.1600  -20.3700
            17  C1x C    25.9700  -19.6700
BOND        18
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    4  10 1
            11   10  11 1
            12   11  12 1
            13    9  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18    9  17 1