Fesoterodine fumarate


Entry
D08923                      Drug                                   
Name
Fesoterodine fumarate (JAN/USAN);
Toviaz (TN)
Product
TOVIAZ (Pfizer Laboratories Div Pfizer), TOVIAZ (U.S. Pharmaceuticals)
  Generic
FESOTERODINE FUMARATE (Ascend Laboratories), FESOTERODINE FUMARATE (Aurobindo Pharma Limited), FESOTERODINE FUMARATE (Cadila Healthcare Limited), FESOTERODINE FUMARATE (Dr.Reddy's Laboratories Inc.,), FESOTERODINE FUMARATE (Golden State Medical Supply), FESOTERODINE FUMARATE (Zydus Pharmaceuticals (USA))
Formula
C26H37NO3. C4H4O4
Exact mass
527.2883
Mol weight
527.649
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2590
ATC code: G04BD11
Chemical structure group: DG00483
Product (DG00483): D08923<JP/US>
Efficacy
Overactive bladder agent, Muscarinic acetylcholine receptor antagonist
Comment
Treatment of overactive bladder
Target
CHRM3 [HSA:1131] [KO:K04131]
CHRM2 [HSA:1129] [KO:K04130]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD11 Fesoterodine
      D08923  Fesoterodine fumarate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Fesoterodine
    D08923  Fesoterodine fumarate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D08923  Fesoterodine fumarate (JAN/USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00483  Fesoterodine
    D08923  Fesoterodine fumarate
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00483  Fesoterodine
    D08923  Fesoterodine fumarate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00483  Fesoterodine
     D08923  Fesoterodine fumarate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM2
     D08923  Fesoterodine fumarate (JAN/USAN) <JP/US>
    CHRM3
     D08923  Fesoterodine fumarate (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D08923
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08923
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D08923
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08923
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08923
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D08923
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00483  Fesoterodine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00483  Fesoterodine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00483  Fesoterodine
Other DBs
CAS: 286930-03-8
PubChem: 96025606
LigandBox: D08923
KCF data

ATOM        38
            1   C1c C    15.5400  -14.9800
            2   N1c N    16.7300  -15.6800
            3   C1b C    17.9200  -15.0500
            4   C1b C    19.1100  -15.7500
            5   C1c C    20.4400  -15.0500
            6   C8y C    21.6300  -15.7500
            7   C8x C    22.8200  -15.0500
            8   C8y C    24.0800  -15.7500
            9   C1b C    25.2700  -15.1200
            10  C1a C    15.5400  -13.5800
            11  C1c C    16.7300  -17.1500
            12  C1a C    15.4700  -17.7800
            13  C1a C    17.9900  -17.7800
            14  C8y C    21.6300  -17.1500
            15  C8x C    24.0800  -17.1500
            16  C8x C    22.8200  -17.8500
            17  O7a O    20.4400  -17.7800
            18  O1a O    26.4600  -15.8200
            19  C1a C    14.3500  -15.6800
            20  C8y C    20.4400  -13.5800
            21  C8x C    21.7000  -12.8800
            22  C8x C    21.7000  -11.4800
            23  C8x C    20.5100  -10.7800
            24  C8x C    19.2500  -11.4100
            25  C8x C    19.2500  -12.8100
            26  C7a C    20.4400  -19.1800
            27  O6a O    21.7000  -19.8100
            28  C1c C    19.2500  -19.8800
            29  C1a C    18.0600  -19.1800
            30  C1a C    19.2500  -21.2800
            31  O6a O    31.5700  -16.7300
            32  C6a C    32.7824  -16.0300
            33  C2b C    33.9949  -16.7300
            34  C2b C    35.2073  -16.0300
            35  C6a C    36.4197  -16.7300
            36  O6a O    37.6322  -16.0300
            37  O6a O    32.7824  -14.6302
            38  O6a O    36.4197  -18.1299
BOND        38
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     5   4 1
            5     5   6 1
            6     6   7 1
            7     7   8 2
            8     8   9 1
            9     1  10 1
            10    2  11 1
            11   11  12 1
            12   11  13 1
            13    6  14 2
            14    8  15 1
            15   14  16 1
            16   16  15 2
            17   14  17 1
            18    9  18 1
            19    1  19 1
            20    5  20 1 #Down
            21   20  21 2
            22   21  22 1
            23   22  23 2
            24   23  24 1
            25   24  25 2
            26   20  25 1
            27   17  26 1
            28   26  27 2
            29   26  28 1
            30   28  29 1
            31   28  30 1
            32   31  32 1
            33   32  33 1
            34   33  34 2
            35   34  35 1
            36   35  36 1
            37   32  37 2
            38   35  38 2