Omacetaxine mepesuccinate


Entry
D08956                      Drug                                   
Name
Omacetaxine mepesuccinate (USAN);
Homoharringtonine;
Synribo (TN)
Product
SYNRIBO (Cephalon)
Formula
C29H39NO9
Exact mass
545.2625
Mol weight
545.6213
Structure
Simcomp
Source
Cephalotaxus [TAX:50178]
Remark
ATC code: L01XX40
Product: D08956<US>
Efficacy
Antineoplastic, Protein biosynthesis inhibitor
  Disease
Chronic myeloid leukemia [DS:H00004]
Target
CCND1 [HSA:595] [KO:K04503]
MCL1 [HSA:4170] [KO:K02539]
MYC [HSA:4609] [KO:K04377]
  Pathway
hsa04010  MAPK signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
hsa05220  Chronic myeloid leukemia
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX40 Omacetaxine mepesuccinate
      D08956  Omacetaxine mepesuccinate (USAN) <US>
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Signaling molecules
   Transcription factor
    MYC
     D08956  Omacetaxine mepesuccinate (USAN) <US>
  Cellular process
   Cell cycle
    CCND1
     D08956  Omacetaxine mepesuccinate (USAN) <US>
   Apoptosis
    MCL1
     D08956  Omacetaxine mepesuccinate (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D08956
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08956
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D08956
Other DBs
CAS: 26833-87-4
PubChem: 96025639
ChEBI: 71019
PDB-CCD: HMT[PDBj]
LigandBox: D08956
NIKKAJI: J123.154E
KCF data

ATOM        39
            1   C8x C    17.6397  -10.6348
            2   C8y C    18.8674  -11.3579
            3   C8y C    16.4129  -11.3276
            4   C8y C    18.8680  -12.7739
            5   C1x C    19.9053  -10.4449
            6   C8y C    16.4136  -12.7437
            7   C1y C    20.0013  -13.6231
            8   C8x C    17.6411  -13.4668
            9   C1x C    21.3216  -10.7589
            10  C1z C    21.3227  -13.2764
            11  C1y C    19.8446  -15.0392
            12  N1y N    21.9515  -12.0173
            13  C2x C    22.0156  -14.5033
            14  C2y C    21.1350  -15.5735
            15  O2a O    21.4189  -16.9266
            16  O2x O    15.0659  -10.8908
            17  C1x C    14.2341  -12.0366
            18  O2x O    15.0672  -13.1819
            19  C1x C    23.5746  -13.6143
            20  C1x C    23.3434  -12.2263
            21  C1x C    22.4975  -14.0511
            22  C1a C    22.7562  -17.3649
            23  O7a O    18.6093  -16.1899
            24  C7a C    18.6093  -17.5899
            25  C1d C    17.4135  -18.2801
            26  O6a O    19.8209  -18.2896
            27  C1b C    16.2093  -17.5846
            28  C7a C    15.0261  -18.2674
            29  O7a O    13.8329  -17.5781
            30  O6a O    15.0258  -19.6698
            31  C1a C    12.6442  -18.2642
            32  C1b C    17.4135  -19.6801
            33  C1b C    16.2178  -20.3704
            34  C1b C    16.2178  -21.7704
            35  C1d C    15.0223  -22.4608
            36  O1a O    13.8099  -23.1608
            37  C1a C    15.7329  -23.6921
            38  C1a C    14.3335  -21.2673
            39  O1a O    18.4034  -19.2700
BOND        43
            1     1   2 1
            2     1   3 2
            3     2   4 2
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    7  11 1
            11    9  12 1
            12   10  13 1
            13   11  14 1
            14   14  15 1
            15    6   8 2
            16   10  12 1
            17   13  14 2
            18    3  16 1
            19   16  17 1
            20   17  18 1
            21    6  18 1
            22   19  20 1
            23   12  20 1
            24   10  21 1 #Down
            25   21  19 1
            26   15  22 1
            27   11  23 1 #Up
            28   23  24 1
            29   24  25 1
            30   24  26 2
            31   25  27 1
            32   27  28 1
            33   28  29 1
            34   28  30 2
            35   29  31 1
            36   25  32 1
            37   32  33 1
            38   33  34 1
            39   34  35 1
            40   35  36 1
            41   35  37 1
            42   35  38 1
            43   25  39 1 #Down