| Entry |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | Fidaxomicin (JAN/USAN); Dificid (TN); Dificlir (TN) | ||||||||
| Product | DIFICID (Merck Sharp & Dohme LLC) | ||||||||
| Formula | C52H74Cl2O18 | ||||||||
| Exact mass | 1056.4252 | ||||||||
| Mol weight | 1058.0392 | ||||||||
| Structure |  | ||||||||
| Class | Antibacterial DG01551 Macrolide antibiotic Metabolizing enzyme inhibitor DG01643 CYP2C9 inhibitor DG01933 CYP2C19 inhibitor DG02852 CYP3A/CYP3A4 inhibitor DG01522 CYP3A4 inhibitor Transporter inhibitor DG01622 ABCB1 inhibitor | ||||||||
| Remark |
| ||||||||
| Efficacy | Antibacterial, Protein biosynthesis inhibitor | ||||||||
| Disease | Clostridium difficile-associated diarrhea [DS:H00338] | ||||||||
| Comment | Treatment of Clostridium difficile-associated diarrhea (CDAD) | ||||||||
| Target | Clostridioides difficile DNA-directed RNA polymerase [KO:K03043 K03046] | ||||||||
| Interaction | CYP inhibition: CYP2C19 [HSA:1557], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576] Transporter inhibition: ABCB1 [HSA:5243] | ||||||||
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] A ALIMENTARY TRACT AND METABOLISM A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS A07A INTESTINAL ANTIINFECTIVES A07AA Antibiotics A07AA12 Fidaxomicin D09394 Fidaxomicin (JAN/USAN) <JP/US> USP drug classification [BR:br08302] Antibacterials Macrolides Fidaxomicin D09394 Fidaxomicin (JAN/USAN) Therapeutic category of drugs in Japan [BR:br08301] 6 Agents against pathologic organisms and parasites 61 Antibiotics 611 Acting mainly on gram-positive bacteria 6119 Others D09394 Fidaxomicin (JAN/USAN) Drug groups [BR:br08330] Antibacterial DG01551 Macrolide antibiotic D09394 Fidaxomicin Metabolizing enzyme inhibitor DG01643 CYP2C9 inhibitor D09394 Fidaxomicin DG01933 CYP2C19 inhibitor D09394 Fidaxomicin DG02852 CYP3A/CYP3A4 inhibitor DG01522 CYP3A4 inhibitor D09394 Fidaxomicin Transporter inhibitor DG01622 ABCB1 inhibitor D09394 Fidaxomicin Drug classes [BR:br08332] Antibacterial DG01551 Macrolide antibiotic D09394 Fidaxomicin Antimicrobials [BR:br08307] Antibacterials Protein biosynthesis inhibitor Aminoglycoside D09394 Fidaxomicin (JAN/USAN) <JP/US> Antimicrobials abbreviations [BR:br08327] Antibacterials Protein biosynthesis inhibitor Aminoglycoside D09394 Fidaxomicin (JAN/USAN) New drug approvals in the USA [br08319.html] New molecular entities and new therapeutic biological products D09394 New drug approvals in Europe [br08329.html] European public assessment reports (EPAR) authorised medicine D09394 New drug approvals in Japan [br08318.html] Drugs with new active ingredients D09394 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D09394 Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D09394 Drug transporters D09394 | ||||||||
| Other DBs |
| ||||||||
| KCF data | ATOM 72 1 C1y C 19.2500 -39.1300 2 C2x C 19.2500 -40.5300 3 C2y C 20.4624 -41.2300 4 C1y C 21.6749 -40.5300 5 C2y C 21.6749 -39.1300 6 C1y C 20.4624 -38.4300 7 C1x C 22.8873 -41.2300 8 C2x C 24.0997 -40.5300 9 C2y C 24.0997 -39.1300 10 C2x C 22.8873 -38.4300 11 C2x C 25.3122 -41.2300 12 C2x C 26.5246 -40.5300 13 C1x C 26.5246 -39.1300 14 C2x C 25.3122 -38.4300 15 C2y C 27.7370 -41.2300 16 C7x C 28.9495 -40.5300 17 O7x O 28.9495 -39.1300 18 C1y C 27.7370 -38.4300 19 C1a C 20.4624 -42.6298 20 C1a C 21.6851 -37.7301 21 C1a C 24.0997 -37.7300 22 C1c C 27.7370 -37.0300 23 O1a O 28.9366 -36.3373 24 C1a C 26.5119 -36.3226 25 O6a O 30.1846 -41.2434 26 C1b C 27.7370 -42.6300 27 O2a O 28.9367 -43.3226 28 C1y C 30.1491 -44.0226 29 C1y C 30.1490 -45.4298 30 C1y C 31.3614 -46.1299 31 C1y C 32.5739 -45.4300 32 C1y C 32.5740 -44.0228 33 O2x O 31.3616 -43.3227 34 C1a C 33.7653 -43.3350 35 O2a O 28.9523 -46.1208 36 C1a C 27.7647 -45.4350 37 O1a O 31.3613 -47.5300 38 O7a O 33.7682 -46.1199 39 C7a C 34.9552 -45.4348 40 C8y C 36.1465 -46.1229 41 O6a O 34.9555 -44.0302 42 C8y C 36.1463 -47.5298 43 C8y C 37.3586 -48.2299 44 C8y C 38.5712 -47.5301 45 C8y C 38.5714 -46.1233 46 C8y C 37.3590 -45.4231 47 C1b C 34.9141 -48.2412 48 C1a C 33.7089 -47.5453 49 X Cl 37.3584 -49.6298 50 O1a O 39.7826 -48.2297 51 X Cl 39.7800 -45.4257 52 O1a O 37.3593 -44.0302 53 O1a O 20.6850 -39.5401 54 C1b C 18.0376 -38.4300 55 C1a C 16.8421 -39.1204 56 O2a O 20.4624 -37.0302 57 C1y C 20.4624 -35.6302 58 O2x O 21.6580 -34.9397 59 C1z C 21.6578 -33.5397 60 C1y C 20.4453 -32.8398 61 C1y C 19.2497 -33.5303 62 C1y C 19.2499 -34.9303 63 O1a O 18.0377 -35.6303 64 O1a O 18.0373 -32.8305 65 C1a C 22.8532 -32.8490 66 C1a C 22.8453 -34.2251 67 O7a O 20.4452 -31.4300 68 C7a C 19.2288 -30.7279 69 O6a O 18.0315 -31.4194 70 C1c C 19.2287 -29.3302 71 C1a C 18.0322 -28.6394 72 C1a C 20.4570 -28.6207 BOND 75 1 1 2 1 2 2 3 2 3 3 4 1 4 5 6 1 5 1 6 1 6 4 7 1 7 7 8 1 8 9 10 1 9 5 10 2 10 8 11 2 11 11 12 1 12 13 14 1 13 9 14 2 14 12 15 2 15 15 16 1 16 16 17 1 17 17 18 1 18 13 18 1 19 3 19 1 20 5 20 1 21 9 21 1 22 18 22 1 23 22 23 1 #Up 24 22 24 1 25 16 25 2 26 15 26 1 27 26 27 1 28 28 27 1 #Down 29 28 29 1 30 29 30 1 31 30 31 1 32 31 32 1 33 32 33 1 34 28 33 1 35 32 34 1 #Down 36 29 35 1 #Down 37 35 36 1 38 30 37 1 #Down 39 31 38 1 #Up 40 38 39 1 41 39 40 1 42 39 41 2 43 40 42 2 44 42 43 1 45 43 44 2 46 44 45 1 47 45 46 2 48 40 46 1 49 42 47 1 50 47 48 1 51 43 49 1 52 44 50 1 53 45 51 1 54 46 52 1 55 4 53 1 #Up 56 1 54 1 #Down 57 54 55 1 58 6 56 1 #Up 59 56 57 1 60 57 58 1 61 58 59 1 62 59 60 1 63 60 61 1 64 61 62 1 65 57 62 1 66 62 63 1 #Up 67 61 64 1 #Up 68 59 65 1 69 59 66 1 70 60 67 1 #Down 71 67 68 1 72 68 69 2 73 68 70 1 74 70 71 1 75 70 72 1 |