Vilazodone hydrochloride

Entry

D09699                      Drug

Name

Vilazodone hydrochloride (USAN);
Viibryd (TN)

Product

VIIBRYD (Allergan), VIIBRYD (Cardinal Health)

Generic

VILAZODONE HYDROCHLORIDE (Accord Healthcare), VILAZODONE HYDROCHLORIDE (Alembic Pharmaceuticals), VILAZODONE (Apotex Corp), VILAZODONE HYDROCHLORIDE (Teva Pharmaceuticals)

Formula

C26H27N5O2. HCl

Exact mass

477.1932

Mol weight

477.9858

Structure

Simcomp

Class

Metabolizing enzyme substrate
DG01639  CYP2C19 substrate
DG01644  CYP2D6 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

ATC code:

N06AX24

Chemical structure group:

DG00964

Product (DG00964):

D09699<US>

Efficacy

Antidepressant, Serotonin antagonist and reuptake inhibitor (SARI)

Disease

Major depressive disorder [DS:H01646]

Target

HTR1A [HSA:3350] [KO:K04153]
SLC6A4 (HTT) [HSA:6532] [KO:K05037]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04726

Serotonergic synapse

Metabolism

Enzyme: CYP3A4 [HSA:1576]; CYP2D6 [HSA:1565], CYP2C19 [HSA:1557]

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX24 Vilazodone
      D09699  Vilazodone hydrochloride (USAN) <US>
USP drug classification [BR:br08302]
Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Vilazodone
    D09699  Vilazodone hydrochloride (USAN)
Drug groups [BR:br08330]
Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   DG00964  Vilazodone
    D09699  Vilazodone hydrochloride
  DG01644  CYP2D6 substrate
   DG00964  Vilazodone
    D09699  Vilazodone hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00964  Vilazodone
     D09699  Vilazodone hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR1A
     D09699  Vilazodone hydrochloride (USAN) <US>
Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D09699  Vilazodone hydrochloride (USAN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D09699
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D09699
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D09699
Drug groups [BR:br08330]
Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   DG00964  Vilazodone
  DG01644  CYP2D6 substrate
   DG00964  Vilazodone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00964  Vilazodone

Other DBs

CAS:	163521-08-2

PubChem:

124490439

ChEBI:

70705

LigandBox:

D09699

KCF data

ATOM        34
            1   C8x C    26.8800  -23.9400
            2   C8y C    26.8800  -25.3400
            3   C8x C    28.0700  -26.0400
            4   C8y C    29.3300  -25.3400
            5   C8y C    29.3300  -23.9400
            6   C8x C    28.0700  -23.2400
            7   C8x C    30.6600  -25.7600
            8   C8y C    31.4300  -24.6400
            9   O2x O    30.6600  -23.5200
            10  N1y N    25.6900  -26.0400
            11  C1x C    24.5000  -25.3400
            12  C1x C    23.2400  -26.0400
            13  N1y N    23.2400  -27.4400
            14  C1x C    24.4300  -28.1400
            15  C1x C    25.6900  -27.4400
            16  C1b C    22.0500  -28.1400
            17  C1b C    20.8600  -27.4400
            18  C1b C    19.6700  -28.1400
            19  C1b C    18.4800  -27.4400
            20  C8y C    17.2900  -28.1400
            21  C8x C    13.7900  -25.8300
            22  C8x C    13.7900  -27.2300
            23  C8y C    14.9800  -27.9300
            24  C8y C    16.2400  -27.2300
            25  C8x C    16.2400  -25.8300
            26  C8y C    14.9800  -25.1300
            27  N4x N    15.2600  -29.3300
            28  C8x C    16.6600  -29.4700
            29  C5a C    32.8300  -24.6400
            30  N1a N    33.5300  -25.8300
            31  O5a O    33.5300  -23.4500
            32  C3b C    14.9800  -23.7300
            33  N3a N    14.9800  -22.3300
            34  X   Cl   19.9500  -24.9900
BOND        37
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    2  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   10  15 1
            18   13  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   25  26 2
            28   21  26 1
            29   23  27 1
            30   27  28 1
            31   28  20 2
            32   24  20 1
            33    8  29 1
            34   29  30 1
            35   29  31 2
            36   26  32 1
            37   32  33 3