Telmisartan and amlodipine besilate


Entry
D09743            Mixture   Drug                                   
Name
Telmisartan and amlodipine besilate (JP18);
Telmisartan and amlodipine besylate;
Micamlo (TN);
Twynsta (TN)
Product
  Generic
TELMISARTAN AND AMLODIPINE (Alembic Pharmaceuticals Limited), TELMISARTAN AND AMLODIPINE (AvKARE), TELMISARTAN AND AMLODIPINE (Lupin Pharmaceuticals), TELMISARTAN AND AMLODIPINE (Mylan Pharmaceuticals), TELMISARTAN AND AMLODIPINE (Torrent Pharmaceuticals Limited)
Component
Telmisartan [DR:D00627], Amlodipine besilate [DR:D00615]
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
 DG03231  Antihypertensive
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02924  UGT substrate
Remark
Therapeutic category: 2149
ATC code: C09DB04
Product: D09743<JP/US>
Efficacy
Antihypertensive
  Disease
Hypertension [DS:H01633]
Comment
Telmisartan is primarily metabolized by UDP-glucuronosyltransferase (UGT).
Amlodipine is primarily metabolized by CYP3A4.
Metabolism
Enzyme: CYP3A4 [HSA:1576], UGT [KO:K00699]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09D ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
    C09DB Angiotensin II receptor blockers (ARBs) and calcium channel blockers
     C09DB04 Telmisartan and amlodipine
      D09743  Telmisartan and amlodipine besilate (JP18) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Cardiovascular Combinations
   Telmisartan/ Amlodipine
    D09743  Telmisartan and amlodipine besilate (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D09743  Telmisartan and amlodipine besilate (JP18)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   D09743  Telmisartan and amlodipine besilate
  DG03231  Antihypertensive
   D09743  Telmisartan and amlodipine besilate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D09743  Telmisartan and amlodipine besilate
  DG02924  UGT substrate
   D09743  Telmisartan and amlodipine besilate
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D09743  Telmisartan and amlodipine besilate
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D09743  Telmisartan and amlodipine besylate tablets
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09743
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09743
Other DBs
PubChem: 124490483