Entry

D09745            Mixture   Drug

Name

Valsartan and amlodipine besilate;
Exforge (TN)

Product

EXFORGE (Novartis Pharmaceuticals Corporation)

Generic

AMLODIPINE AND VALSARTAN (Alembic Pharmaceuticals), AMLODIPINE AND VALSARTAN (Alembic Pharmaceuticals Limited), AMLODIPINE AND VALSARTAN (Aurobindo Pharma Limited), AMLODIPINE AND VALSARTAN (Lupin Pharmaceuticals), AMLODIPINE AND VALSARTAN (Lupin Pharmaceuticals), AMLODIPINE AND VALSARTAN (Mylan Pharmaceuticals), AMLODIPINE AND VALSARTAN (Strides Pharma Science Limited)

Component

Valsartan [DR:D00400], Amlodipine besilate [DR:D00615]

Class

Cardiovascular agent
DG01925  Renin-angiotensin system inhibitor
DG03231  Antihypertensive
Metabolizing enzyme substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Therapeutic category:

2149

ATC code:

C09DB01

Product:

D09745<JP/US>

Efficacy

Antihypertensive

Disease

Hypertension [DS:H01633]

Comment

Anmlodipine is metabolized by CYP3A4.

Metabolism

Enzyme: CYP3A4 [HSA:1576]

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09D ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
    C09DB Angiotensin II receptor blockers (ARBs) and calcium channel blockers
     C09DB01 Valsartan and amlodipine
      D09745  Valsartan and amlodipine besilate <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
  Cardiovascular Combinations
   Amlodipine/ Valsartan
    D09745  Valsartan and amlodipine besilate
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D09745  Valsartan and amlodipine besilate
Drug groups [BR:br08330]
Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   D09745  Valsartan and amlodipine besilate
  DG03231  Antihypertensive
   D09745  Valsartan and amlodipine besilate
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D09745  Valsartan and amlodipine besilate
Drug classes [BR:br08332]
Cardiovascular agent
  DG03231  Antihypertensive
   D09745  Valsartan and amlodipine besilate
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D09745
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D09745

Other DBs

PubChem:

124490485