| Entry |
| ||||||
|---|---|---|---|---|---|---|---|
| Name | Tofogliflozin (USAN); Tofogliflozin hydrate (JAN); Apleway (TN); Deberza (TN) | ||||||
| Formula | C22H26O6. H2O | ||||||
| Exact mass | 404.1835 | ||||||
| Mol weight | 404.4535 | ||||||
| Structure |  | ||||||
| Class | Antidiabetic agent DG02044 Hypoglycemic agent DG01794 SGLT2 inhibitor Metabolizing enzyme substrate DG02977 CYP2C18 substrate DG02978 CYP4A11 substrate DG02979 CYP4F3 substrate | ||||||
| Remark |
| ||||||
| Efficacy | Antidiabetic, SGLT-2 inhibitor | ||||||
| Comment | Phlorizin derivative Treatment of diabetes mellitus | ||||||
| Target | SLC5A2 (SGLT2) [HSA:6524] [KO:K14382] | ||||||
| Metabolism | Enzyme: CYP2C18 [HSA:1562], CYP4A11 [HSA:1579], CYP4F3 [HSA:4051] | ||||||
| Interaction | |||||||
| Structure map |
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| Brite | Therapeutic category of drugs in Japan [BR:br08301] 3 Agents affecting metabolism 39 Other agents affecting metabolism 396 Antidiabetic agents 3969 Others D09978 Tofogliflozin (USAN); Tofogliflozin hydrate (JAN) Drug groups [BR:br08330] Antidiabetic agent DG02044 Hypoglycemic agent DG01794 SGLT2 inhibitor D09978 Tofogliflozin Metabolizing enzyme substrate DG02977 CYP2C18 substrate D09978 Tofogliflozin DG02978 CYP4A11 substrate D09978 Tofogliflozin DG02979 CYP4F3 substrate D09978 Tofogliflozin Drug classes [BR:br08332] Antidiabetic agent DG01794 SGLT2 inhibitor D09978 Tofogliflozin DG02044 Hypoglycemic agent D09978 Tofogliflozin Target-based classification of drugs [BR:br08310] Transporters Solute carrier family SLC5 SLC5A2 (SGLT2) D09978 Tofogliflozin (USAN) <JP> New drug approvals in Japan [br08318.html] Drugs with new active ingredients D09978 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D09978 Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D09978 | ||||||
| Other DBs |
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| KCF data | ATOM 29 1 O0 O 22.8312 -19.4121 2 C1y C 12.7429 -15.8246 3 C1y C 12.7429 -17.2251 4 C1y C 13.9333 -17.9253 5 C1z C 15.1936 -17.2251 6 O2x O 15.1936 -15.8246 7 C1y C 13.9333 -15.1244 8 C1b C 13.9333 -13.7240 9 O1a O 11.5525 -17.9253 10 O1a O 11.5525 -15.1244 11 O1a O 13.9333 -19.3257 12 O1a O 15.1236 -13.0237 13 O2x O 15.1936 -18.6255 14 C1x C 16.5241 -19.0456 15 C8y C 17.3643 -17.9253 16 C8y C 16.5241 -16.8049 17 C8x C 18.7648 -17.7852 18 C8x C 19.3249 -16.4548 19 C8y C 18.4847 -15.3345 20 C8x C 17.0842 -15.5445 21 C1b C 19.6751 -14.6342 22 C8y C 20.8654 -15.3345 23 C8x C 20.8654 -16.7349 24 C8x C 22.1258 -17.4351 25 C8y C 23.3162 -16.7349 26 C8x C 23.3162 -15.3345 27 C8x C 22.1258 -14.6342 28 C1b C 24.5066 -17.4351 29 C1a C 25.6969 -16.7349 BOND 31 1 2 3 1 2 3 4 1 3 4 5 1 4 5 6 1 5 6 7 1 6 2 7 1 7 7 8 1 #Up 8 3 9 1 #Up 9 2 10 1 #Down 10 4 11 1 #Down 11 8 12 1 12 5 13 1 #Down 13 13 14 1 14 14 15 1 15 15 16 2 16 5 16 1 #Up 17 15 17 1 18 17 18 2 19 18 19 1 20 19 20 2 21 16 20 1 22 21 22 1 23 21 19 1 24 22 23 2 25 23 24 1 26 24 25 2 27 25 26 1 28 26 27 2 29 22 27 1 30 25 28 1 31 28 29 1 |