| Entry |
| ||||||
|---|---|---|---|---|---|---|---|
| Name | Vardenafil hydrochloride (USP) | ||||||
| Formula | C23H32N6O4S. HCl | ||||||
| Exact mass | 524.1973 | ||||||
| Mol weight | 525.0639 | ||||||
| Structure |  | ||||||
| Simcomp | |||||||
| Class | Cardiovascular agent DG01509 Phosphodiesterase V inhibitor Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate | ||||||
| Remark |
| ||||||
| Efficacy | Vasodilator, Impotence therapy, Phosphodiesterase V inhibitor | ||||||
| Comment | Treatment of erectile dysfunction | ||||||
| Target | PDE5 [HSA:8654] [KO:K13762] | ||||||
| Pathway |
| ||||||
| Metabolism | Enzyme: CYP3A4 [HSA:1576] | ||||||
| Interaction | |||||||
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] G GENITO URINARY SYSTEM AND SEX HORMONES G04 UROLOGICALS G04B UROLOGICALS G04BE Drugs used in erectile dysfunction G04BE09 Vardenafil D09989 Vardenafil hydrochloride (USP) Drug groups [BR:br08330] Cardiovascular agent DG01509 Phosphodiesterase V inhibitor DG00487 Vardenafil D09989 Vardenafil hydrochloride Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate DG00487 Vardenafil D09989 Vardenafil hydrochloride Target-based classification of drugs [BR:br08310] Enzymes Hydrolases (EC3) Phosphodiesterases PDE5 D09989 Vardenafil hydrochloride (USP) New drug approvals in Europe [br08329.html] European public assessment reports (EPAR) authorised medicine D09989 Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D09989 Drug groups [BR:br08330] Cardiovascular agent DG01509 Phosphodiesterase V inhibitor DG00487 Vardenafil Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate DG00487 Vardenafil | ||||||
| Other DBs |
| ||||||
| KCF data | ATOM 35 1 C8y C 28.7700 -28.2800 2 C8y C 29.9600 -27.5800 3 C8y C 28.7700 -29.6800 4 C8x C 27.5100 -27.5800 5 N4x N 31.1500 -28.2800 6 N5x N 29.9600 -26.1800 7 C8x C 27.5100 -30.3800 8 O2a O 29.9600 -30.3800 9 C8y C 26.3200 -28.2800 10 N4y N 32.4100 -27.5800 11 C8y C 31.1500 -25.4800 12 C8x C 26.3200 -29.6800 13 C1b C 31.1500 -29.6800 14 S4a S 25.1300 -27.5800 15 C8y C 32.4100 -26.1800 16 C8y C 33.7400 -28.0000 17 O5x O 31.1500 -24.0100 18 C1a C 32.3400 -30.3800 19 N1y N 23.9400 -28.2800 20 O3c O 26.1100 -26.6000 21 O3c O 24.1500 -26.6000 22 C8y C 33.7400 -25.7600 23 N5x N 34.5800 -26.8800 24 C1b C 34.1600 -29.3300 25 C1x C 23.9400 -29.6800 26 C1x C 22.6800 -27.5800 27 C1a C 34.1600 -24.4300 28 C1b C 35.4900 -29.6100 29 C1x C 22.6800 -30.3800 30 C1x C 21.4900 -28.2800 31 C1a C 35.9100 -30.9400 32 N1y N 21.4900 -29.6800 33 C1b C 20.3000 -30.3800 34 C1a C 19.1100 -29.6800 35 X Cl 38.2200 -26.8100 BOND 37 1 1 2 1 2 1 3 1 3 1 4 2 4 2 5 1 5 2 6 2 6 3 7 2 7 3 8 1 8 4 9 1 9 5 10 1 10 6 11 1 11 7 12 1 12 8 13 1 13 9 14 1 14 10 15 1 15 10 16 1 16 11 17 2 17 13 18 1 18 14 19 1 19 14 20 2 20 14 21 2 21 15 22 2 22 16 23 2 23 16 24 1 24 19 25 1 25 19 26 1 26 22 27 1 27 24 28 1 28 25 29 1 29 26 30 1 30 28 31 1 31 29 32 1 32 32 33 1 33 9 12 2 34 11 15 1 35 22 23 1 36 30 32 1 37 33 34 1 |