Entry

D09999            Mixture   Drug

Name

Tramadol hydrochloride and acetaminophen;
Tramcet (TN)

Product

ULTRACET (Janssen Pharmaceuticals)

Generic

TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (A-S Medication Solutions), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (A-S Medication Solutions), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (American Health Packaging), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Amneal Pharmaceuticals LLC), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Amneal Pharmaceuticals of New York LLC), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Asclemed USA), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Asclemed USA), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Aurobindo Pharma Limited), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (AvPAK), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Cadila Healthcare Limited), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (DIRECT RX), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Golden State Medical Supply), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Medsource Pharmaceuticals), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Micro Labs Limited), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Preferred Pharmaceuticals), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Preferred Pharmaceuticals), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Proficient Rx LP), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Proficient Rx LP), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Proficient Rx LP), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (REMEDYREPACK), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (St. Mary's Medical Park Pharmacy), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (St. Mary's Medical Park Pharmacy), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Sun Pharmaceutical Industries), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Zydus Pharmaceuticals (USA))

Component

Tramadol hydrochloride [DR:D01355], Acetaminophen [DR:D00217]

Class

Analgesic
DG01984  Opioid analgesics
Metabolizing enzyme substrate
DG01644  CYP2D6 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Therapeutic category:

1149

ATC code:

N02AJ13

Product:

D09999<JP/US>

Efficacy

Pain relief

Comment

Tramadol is a substrate of CYP2D6 and CYP3A4.

Metabolism

Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AJ Opioids in combination with non-opioid analgesics
     N02AJ13 Tramadol and paracetamol
      D09999  Tramadol hydrochloride and acetaminophen <JP/US>
USP drug classification [BR:br08302]
Analgesics
  Analgesics Combinations
   Tramadol Hydrochloride/ Acetaminophen
    D09999  Tramadol hydrochloride and acetaminophen
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D09999  Tramadol hydrochloride and acetaminophen
Drug groups [BR:br08330]
Analgesic
  DG01984  Opioid analgesics
   D09999  Tramadol hydrochloride and acetaminophen
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D09999  Tramadol hydrochloride and acetaminophen
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D09999  Tramadol hydrochloride and acetaminophen
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D09999
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D09999

Other DBs

PubChem:

135626720