| Entry |
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|---|---|---|---|---|---|---|---|---|---|
| Name | Asunaprevir (JAN/USAN); Sunvepra (TN) | ||||||||
| Abbr | ASV | ||||||||
| Formula | C35H46ClN5O9S | ||||||||
| Exact mass | 747.2705 | ||||||||
| Mol weight | 748.2858 | ||||||||
| Structure |  | ||||||||
| Class | Antiviral DG03198 Anti-HCV agent DG02001 HCV NS3/4A protease inhibitor Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate Metabolizing enzyme inhibitor DG01645 CYP2D6 inhibitor Metabolizing enzyme inducer DG02853 CYP3A/CYP3A4 inducer DG01635 CYP3A4 inducer Transporter substrate DG01665 ABCB1 substrate DG02856 SLCO1B1 substrate Transporter inhibitor DG01622 ABCB1 inhibitor DG02865 SLCO1B1 inhibitor DG02907 SLCO1B3 inhibitor | ||||||||
| Remark |
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| Efficacy | Antiviral, Protease inhibitor | ||||||||
| Comment | Treatment of hepatitis C | ||||||||
| Target | HCV NS3/4A protease [KO:K22273 K22274] | ||||||||
| Pathway |
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| Metabolism | Enzyme: CYP3A [HSA:1576 1577 1551] Transporter: ABCB1 [HSA:5243], SLCO1B1 [HSA:10599] | ||||||||
| Interaction | CYP inhibition: CYP2D6 [HSA:1565] CYP induction: CYP3A4 [HSA:1576] Transporter inhibition: SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234], ABCB1 [HSA:5243] | ||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] J ANTIINFECTIVES FOR SYSTEMIC USE J05 ANTIVIRALS FOR SYSTEMIC USE J05A DIRECT ACTING ANTIVIRALS J05AP Antivirals for treatment of HCV infections J05AP06 Asunaprevir D10093 Asunaprevir (JAN/USAN) Drug groups [BR:br08330] Antiviral DG03198 Anti-HCV agent DG02001 HCV NS3/4A protease inhibitor D10093 Asunaprevir Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate D10093 Asunaprevir Metabolizing enzyme inhibitor DG01645 CYP2D6 inhibitor D10093 Asunaprevir Metabolizing enzyme inducer DG02853 CYP3A/CYP3A4 inducer DG01635 CYP3A4 inducer D10093 Asunaprevir Transporter substrate DG01665 ABCB1 substrate D10093 Asunaprevir DG02856 SLCO1B1 substrate D10093 Asunaprevir Transporter inhibitor DG01622 ABCB1 inhibitor D10093 Asunaprevir DG02865 SLCO1B1 inhibitor D10093 Asunaprevir DG02907 SLCO1B3 inhibitor D10093 Asunaprevir Antimicrobials [BR:br08307] Antivirals Polyprotein cleavage inhibitor HCV NS3/4A inhibitor D10093 Asunaprevir (JAN/USAN) Antimicrobials abbreviations [BR:br08327] Antivirals Polyprotein cleavage inhibitor HCV NS3/4A inhibitor D10093 Asunaprevir (JAN/USAN) New drug approvals in Japan [br08318.html] Drugs with new active ingredients D10093 Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D10093 Drug transporters D10093 | ||||||||
| Other DBs |
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| KCF data | ATOM 51 1 C8y C 14.3982 -18.8068 2 C8y C 14.3982 -20.1980 3 C8y C 15.5807 -20.8935 4 C8x C 16.8327 -20.1980 5 N5x N 16.8327 -18.8068 6 C8y C 15.5807 -18.1113 7 C8x C 13.2158 -18.1113 8 C8y C 11.9637 -18.8068 9 C8x C 11.9637 -20.1980 10 C8x C 13.2158 -20.8935 11 X Cl 10.7813 -18.1113 12 O2a O 15.5807 -22.2847 13 C1a C 14.3982 -22.9802 14 O2a O 15.5807 -16.7201 15 C1y C 16.7631 -16.0246 16 C1x C 18.0847 -16.4419 17 C1y C 18.8498 -15.3290 18 N1y N 18.0152 -14.2161 19 C1x C 16.7631 -14.7030 20 C5a C 20.2410 -15.2594 21 O5a O 20.9365 -16.4419 22 N1b N 20.9365 -14.0770 23 C1z C 23.0928 -14.0770 24 C5a C 18.0152 -12.8250 25 O5a O 19.1976 -12.1294 26 C1c C 16.8327 -12.1294 27 N1b N 15.6502 -12.8250 28 C7a C 14.4678 -12.1294 29 O7a O 13.2853 -12.8250 30 O6a O 14.4678 -10.7383 31 C1d C 12.1029 -12.1294 32 C1a C 10.9204 -12.8250 33 C1a C 12.1029 -10.7383 34 C1a C 10.8508 -11.4338 35 C1d C 16.8327 -10.7383 36 C1a C 15.6502 -10.0427 37 C1a C 18.0152 -10.0427 38 C1a C 16.8327 -9.3471 39 C1x C 24.3448 -14.8421 40 C1y C 24.3448 -13.4510 41 C2b C 25.1099 -12.2685 42 C2a C 26.5011 -12.2685 43 C5a C 23.0928 -15.4681 44 O5a O 24.2753 -16.1637 45 N1b N 21.9103 -16.1637 46 S4a S 21.9103 -17.5548 47 O3c O 23.3015 -17.5548 48 O3c O 20.5192 -17.5548 49 C1y C 21.9103 -18.9460 50 C1x C 21.2148 -20.1284 51 C1x C 22.6059 -20.1284 BOND 55 1 1 2 2 2 2 3 1 3 3 4 2 4 4 5 1 5 5 6 2 6 1 6 1 7 1 7 1 8 7 8 2 9 8 9 1 10 9 10 2 11 2 10 1 12 8 11 1 13 3 12 1 14 12 13 1 15 6 14 1 16 15 14 1 #Up 17 15 16 1 18 16 17 1 19 17 18 1 20 18 19 1 21 15 19 1 22 17 20 1 #Down 23 20 21 2 24 20 22 1 25 22 23 1 26 18 24 1 27 24 25 2 28 26 24 1 #Up 29 26 27 1 30 27 28 1 31 28 29 1 32 28 30 2 33 29 31 1 34 31 32 1 35 31 33 1 36 31 34 1 37 26 35 1 38 35 36 1 39 35 37 1 40 35 38 1 41 23 39 1 42 39 40 1 43 40 23 1 44 40 41 1 #Down 45 41 42 2 46 23 43 1 #Down 47 43 44 2 48 43 45 1 49 45 46 1 50 46 47 2 51 46 48 2 52 46 49 1 53 50 51 1 54 51 49 1 55 49 50 1 |