| Entry |
| ||||||
|---|---|---|---|---|---|---|---|
| Name | Trelagliptin succinate (JAN/USAN); Zafatek (TN) | ||||||
| Formula | C18H20FN5O2. C4H6O4 | ||||||
| Exact mass | 475.1867 | ||||||
| Mol weight | 475.4701 | ||||||
| Structure |  | ||||||
| Simcomp | |||||||
| Class | Antidiabetic agent DG02044 Hypoglycemic agent DG01601 DPP-4 inhibitor Metabolizing enzyme substrate DG01644 CYP2D6 substrate | ||||||
| Remark |
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| Efficacy | Antidiabetic, Dipeptidyl peptidase-4 (DPP-4) inhibitor | ||||||
| Disease | Type 2 diabetes mellitus [DS:H00409] | ||||||
| Comment | Treatment of type 2 diabetes | ||||||
| Target | DPP4 (CD26) [HSA:1803] [KO:K01278] | ||||||
| Pathway |
| ||||||
| Metabolism | Enzyme: CYP2D6 [HSA:1565] | ||||||
| Interaction | |||||||
| Brite | Therapeutic category of drugs in Japan [BR:br08301] 3 Agents affecting metabolism 39 Other agents affecting metabolism 396 Antidiabetic agents 3969 Others D10179 Trelagliptin succinate (JAN/USAN) Drug groups [BR:br08330] Antidiabetic agent DG02044 Hypoglycemic agent DG01601 DPP-4 inhibitor DG01284 Trelagliptin D10179 Trelagliptin succinate Metabolizing enzyme substrate DG01644 CYP2D6 substrate DG01284 Trelagliptin D10179 Trelagliptin succinate Drug classes [BR:br08332] Antidiabetic agent DG01601 DPP-4 inhibitor D10179 Trelagliptin succinate DG02044 Hypoglycemic agent D10179 Trelagliptin succinate Target-based classification of drugs [BR:br08310] Enzymes Hydrolases (EC3) Peptidyl-peptidases DPP4 (CD26) D10179 Trelagliptin succinate (JAN/USAN) <JP> New drug approvals in Japan [br08318.html] Drugs with new active ingredients D10179 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D10179 Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D10179 Drug groups [BR:br08330] Antidiabetic agent DG02044 Hypoglycemic agent DG01601 DPP-4 inhibitor DG01284 Trelagliptin Metabolizing enzyme substrate DG01644 CYP2D6 substrate DG01284 Trelagliptin | ||||||
| Other DBs |
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| KCF data | ATOM 34 1 C8x C 26.1100 -23.5200 2 C8y C 26.1100 -24.9200 3 N4y N 24.9200 -25.6200 4 C8y C 23.6600 -24.9200 5 N4y N 23.6600 -23.5200 6 C8y C 24.9200 -22.8200 7 C1b C 22.4000 -22.8200 8 C8y C 21.2100 -23.5200 9 C8x C 21.2100 -24.9200 10 C8y C 19.9500 -25.6200 11 C8x C 18.7600 -24.9200 12 C8x C 18.7600 -23.5200 13 C8y C 19.9500 -22.8200 14 C3b C 19.9500 -21.4200 15 X F 19.9500 -27.0200 16 C1a C 24.9200 -27.0200 17 O5x O 27.3000 -25.6200 18 O5x O 22.4000 -25.6200 19 N1y N 24.9200 -21.4200 20 C1x C 23.7300 -20.7200 21 C1y C 23.7300 -19.3200 22 C1x C 24.9200 -18.6200 23 C1x C 26.1100 -19.3200 24 C1x C 26.1100 -20.7200 25 N3a N 19.9500 -20.0200 26 N1a N 22.4700 -18.6200 27 O6a O 28.4200 -21.9800 28 C6a C 29.6324 -22.6800 29 C1b C 30.8279 -21.9896 30 C1b C 32.0153 -22.6751 31 C6a C 33.2065 -21.9871 32 O6a O 34.3960 -22.6738 33 O6a O 33.2065 -20.5803 34 O6a O 29.6325 -24.0798 BOND 35 1 1 2 1 2 2 3 1 3 3 4 1 4 4 5 1 5 5 6 1 6 1 6 2 7 5 7 1 8 7 8 1 9 8 9 2 10 9 10 1 11 10 11 2 12 11 12 1 13 12 13 2 14 8 13 1 15 13 14 1 16 10 15 1 17 3 16 1 18 2 17 2 19 4 18 2 20 6 19 1 21 19 20 1 22 20 21 1 23 21 22 1 24 22 23 1 25 23 24 1 26 19 24 1 27 14 25 3 28 21 26 1 #Down 29 27 28 1 30 28 29 1 31 29 30 1 32 30 31 1 33 31 32 1 34 31 33 2 35 28 34 2 |