Entry

D10246            Mixture   Drug

Name

Omeprazole, clarithromycin and amoxicillin;
Omeclamox-pak (TN)

Product

OMECLAMOX-PAK (Cumberland Pharmaceuticals)

Component

Omeprazole [DR:D00455], Clarithromycin [DR:D00276], (Amoxicillin hydrate [DR:D00229] | Amoxicillin [DR:D07452])

Class

Metabolizing enzyme substrate
DG01639  CYP2C19 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852  CYP3A/CYP3A4 inhibitor
  DG01522  CYP3A4 inhibitor
Transporter inhibitor
DG01622  ABCB1 inhibitor

Remark

ATC code:

A02BD05

Product:

D10246<US>

Efficacy

Antibacterial

Disease

Helicobacter pylori infection [DS:H00320]

Comment

Omeprazole is metabolized by CYP2C19 with some contribution from CYP3A4.
Clarithromycin is an inhibitor and a substrate of CYP3A4, and it is an inhibitor of P-gp.

Metabolism

Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]

Interaction

CYP inhibition: CYP3A4 [HSA:1576]
Transporter inhibition: ABCB1 [HSA:5243]

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BD Combinations for eradication of Helicobacter pylori
     A02BD05 Omeprazole, amoxicillin and clarithromycin
      D10246  Omeprazole, clarithromycin and amoxicillin <US>
USP drug classification [BR:br08302]
Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Omeprazole/ Clarithromycin/ Amoxicillin
    D10246  Omeprazole, clarithromycin and amoxicillin
Drug groups [BR:br08330]
Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D10246  Omeprazole, clarithromycin and amoxicillin
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D10246  Omeprazole, clarithromycin and amoxicillin
Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG01522  CYP3A4 inhibitor
    D10246  Omeprazole, clarithromycin and amoxicillin
Transporter inhibitor
  DG01622  ABCB1 inhibitor
   D10246  Omeprazole, clarithromycin and amoxicillin
Antimicrobials [BR:br08307]
Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Extended spectrum penicillin
    D10246  Omeprazole, clarithromycin and amoxicillin <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D10246
Drug transporters
  D10246

Other DBs

PubChem:

163312277