Entry

D10541                      Drug

Name

Aducanumab (USAN);
Aducanumab (genetical recombination) (JAN);
Aduhelm (TN)

Product

ADUHELM (Biogen)

Formula

C6472H10028N1740O2014S46

Exact mass

145820.2915

Mol weight

145910.3123

Sequence

(Heavy chain)
XVQLVESGGG VVQPGRSLRL SCAASGFAFS SYGMHWVRQA PGKGLEWVAV IWFDGTKKYY
TDSVKGRFTI SRDNSKNTLY LQMNTLRAED TAVYYCARDR GIGARRGPYY MDVWGKGTTV
TVSSASTKGP SVFPLAPSSK STSGGTAALG CLVKDYFPEP VTVSWNSGAL TSGVHTFPAV
LQSSGLYSLS SVVTVPSSSL GTQTYICNVN HKPSNTKVDK RVEPKSCDKT HTCPPCPAPE
LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE
EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP
SREEMTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD
KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPG
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQSIS SYLNWYQQKP GKAPKLLIYA ASSLQSGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SYSTPLTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H151-H207, H227-L214, H233-H'233, H236-H'236, H268-H328, H374-H432, H'22-H'96, H'151-H'207, H'227-L'214, H'268-H'328, H'374-H'432, L23-L88, L134-L194, L'23-L'88, L'134-L'194)

Type

Peptide

Class

Neuropsychiatric agent
DG01968 Antidementia agent

Remark

ATC code:

N06DX03

Product:

D10541<US>

Efficacy

Dementia therapeutic agent

Disease

Alzheimer's disease [DS:H00056]

Comment

Monoclonal antibody
Treatment of Alzheimers disease

Target

Amyloid beta [CPD:C16514 C16515]

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DX Other anti-dementia drugs
     N06DX03 Aducanumab
      D10541  Aducanumab (USAN) <US>
USP drug classification [BR:br08302]
Antidementia Agents
  Antidementia Agents, Other
   Aducanumab
    D10541  Aducanumab (USAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01968  Antidementia agent
   D10541  Aducanumab
Drug classes [BR:br08332]
Neuropsychiatric agent
  DG01968  Antidementia agent
   D10541  Aducanumab
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D10541
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D10541

Other DBs

CAS:	1384260-65-4

PubChem:

254741503