| Entry |
| ||||||
|---|---|---|---|---|---|---|---|
| Name | Elbasvir (JAN/USAN/INN); Erelsa (TN) | ||||||
| Abbr | EBR | ||||||
| Formula | C49H55N9O7 | ||||||
| Exact mass | 881.4224 | ||||||
| Mol weight | 882.0171 | ||||||
| Structure |  | ||||||
| Class | Antiviral DG03198 Anti-HCV agent DG01999 HCV NS5A inhibitor Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate Transporter substrate DG01665 ABCB1 substrate Transporter inhibitor DG01622 ABCB1 inhibitor DG02862 ABCG2 inhibitor | ||||||
| Remark |
| ||||||
| Efficacy | Antiviral, NS5A inhibitor | ||||||
| Comment | Treatment of Hepatis C | ||||||
| Target | HCV NS5A [KO:K22275] | ||||||
| Pathway |
| ||||||
| Metabolism | Enzyme: CYP3A [HSA:1576 1577 1551] Transporter: ABCB1 [HSA:5243] | ||||||
| Interaction | Transporter inhibition: ABCG2 [HSA:9429], ABCB1 [HSA:5243] | ||||||
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] J ANTIINFECTIVES FOR SYSTEMIC USE J05 ANTIVIRALS FOR SYSTEMIC USE J05A DIRECT ACTING ANTIVIRALS J05AP Antivirals for treatment of HCV infections J05AP10 Elbasvir D10625 Elbasvir (JAN/USAN/INN) Therapeutic category of drugs in Japan [BR:br08301] 6 Agents against pathologic organisms and parasites 62 Chemotherapeutics 625 Antivirals 6250 Antivirals D10625 Elbasvir (JAN/USAN/INN) Drug groups [BR:br08330] Antiviral DG03198 Anti-HCV agent DG01999 HCV NS5A inhibitor D10625 Elbasvir Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate D10625 Elbasvir Transporter substrate DG01665 ABCB1 substrate D10625 Elbasvir Transporter inhibitor DG01622 ABCB1 inhibitor D10625 Elbasvir DG02862 ABCG2 inhibitor D10625 Elbasvir Antimicrobials [BR:br08307] Antivirals Genome replication inhibitor HCV NS5A/NS5B inhibitor D10625 Elbasvir (JAN/USAN/INN) Antimicrobials abbreviations [BR:br08327] Antivirals Genome replication inhibitor HCV NS5A/NS5B inhibitor D10625 Elbasvir (JAN/USAN/INN) New drug approvals in Japan [br08318.html] Drugs with new active ingredients D10625 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D10625 Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D10625 Drug transporters D10625 | ||||||
| Other DBs |
| ||||||
| KCF data | ATOM 65 1 C1y C 13.2300 -23.8000 2 N1y N 11.9000 -24.2200 3 C1x C 11.9000 -25.6200 4 C1x C 13.2300 -26.0400 5 C1x C 14.0700 -24.9200 6 C8y C 14.9800 -20.5800 7 C8x C 13.6500 -20.1600 8 N5x N 12.8100 -21.3500 9 C8y C 13.6500 -22.4700 10 N4x N 14.9800 -22.0500 11 C8y C 16.1000 -19.8800 12 C8x C 17.2900 -20.5800 13 C8x C 18.5500 -19.8800 14 C8y C 18.5500 -18.4800 15 C8y C 17.3600 -17.7800 16 C8x C 16.1000 -18.4800 17 N4y N 19.5300 -17.5700 18 C8y C 18.9700 -16.3100 19 C8x C 17.6400 -16.4500 20 C1y C 20.9300 -17.7100 21 O2x O 21.7700 -16.5900 22 C8y C 21.2100 -15.3300 23 C8y C 19.8100 -15.1200 24 C8x C 22.0500 -14.1400 25 C8y C 21.4900 -12.9500 26 C8x C 20.0900 -12.8100 27 C8x C 19.2500 -13.8600 28 C8y C 21.4900 -18.9700 29 C8x C 22.8900 -19.1100 30 C8x C 20.7200 -20.0900 31 C8x C 21.2800 -21.3500 32 C8x C 22.6800 -21.5600 33 C8x C 23.4500 -20.3700 34 C2y C 22.4700 -11.9700 35 C1x C 23.8700 -12.1800 36 N2x N 24.5000 -10.9200 37 C2y C 23.5200 -9.9400 38 N2x N 22.2600 -10.5700 39 C1y C 23.8700 -8.6100 40 N1y N 25.1300 -8.0500 41 C1x C 25.1300 -6.6500 42 C1x C 23.7300 -6.3000 43 C1x C 22.9600 -7.4900 44 C5a C 10.7100 -23.5200 45 C1c C 9.5200 -24.2200 46 O5a O 10.7100 -22.1200 47 N1b N 8.3300 -23.5200 48 C1c C 9.5200 -25.6200 49 C1a C 10.7100 -26.3200 50 C1a C 8.3300 -26.3200 51 C7a C 7.1400 -24.2200 52 O6a O 5.9500 -23.5200 53 O7a O 7.1400 -25.6200 54 C1a C 5.9500 -26.3200 55 C5a C 26.3200 -8.7500 56 C1c C 27.5100 -8.0500 57 O5a O 26.3200 -10.1500 58 N1b N 28.7281 -8.7401 59 C1c C 27.4986 -6.6500 60 C1a C 26.2892 -5.9648 61 C1a C 28.7138 -5.9352 62 C7a C 29.9095 -8.0450 63 O6a O 31.1149 -8.7280 64 O7a O 29.8981 -6.6500 65 C1a C 31.1083 -5.9603 BOND 73 1 1 2 1 2 2 3 1 3 3 4 1 4 4 5 1 5 1 5 1 6 6 7 2 7 7 8 1 8 8 9 2 9 9 10 1 10 6 10 1 11 6 11 1 12 11 12 2 13 12 13 1 14 13 14 2 15 14 15 1 16 15 16 2 17 11 16 1 18 14 17 1 19 17 18 1 20 18 19 2 21 15 19 1 22 17 20 1 23 20 21 1 24 21 22 1 25 22 23 2 26 18 23 1 27 22 24 1 28 24 25 2 29 25 26 1 30 26 27 2 31 23 27 1 32 28 29 1 33 28 30 2 34 30 31 1 35 31 32 2 36 32 33 1 37 29 33 2 38 20 28 1 #Up 39 25 34 1 40 34 35 1 41 35 36 1 42 36 37 2 43 37 38 1 44 34 38 2 45 1 9 1 #Down 46 39 40 1 47 40 41 1 48 41 42 1 49 42 43 1 50 39 43 1 51 39 37 1 #Down 52 44 2 1 53 44 45 1 54 44 46 2 55 45 47 1 #Down 56 45 48 1 57 48 49 1 58 48 50 1 59 47 51 1 60 51 52 2 61 51 53 1 62 53 54 1 63 40 55 1 64 55 56 1 65 55 57 2 66 56 58 1 #Down 67 56 59 1 68 59 60 1 69 59 61 1 70 58 62 1 71 62 63 2 72 62 64 1 73 64 65 1 |