| Entry |
| ||||||
|---|---|---|---|---|---|---|---|
| Name | Plazomicin sulfate (USAN); Zemdri (TN) | ||||||
| Product | ZEMDRI (PLAZOMICIN) (Achaogen), ZEMDRI (PLAZOMICIN) (Cipla Therapeutics), ZEMDRI (PLAZOMICIN) (Cipla USA) | ||||||
| Formula | C25H48N6O10. xH2SO4 | ||||||
| Structure |  | ||||||
| Simcomp | |||||||
| Class | Antibacterial DG01447 Aminoglycoside antibiotic | ||||||
| Remark |
| ||||||
| Efficacy | Antibacterial, Protein biosynthesis inhibitor | ||||||
| Comment | Aminoglycoside | ||||||
| Target | 30S ribosomal subunit | ||||||
| Pathway |
| ||||||
| Interaction | |||||||
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] J ANTIINFECTIVES FOR SYSTEMIC USE J01 ANTIBACTERIALS FOR SYSTEMIC USE J01G AMINOGLYCOSIDE ANTIBACTERIALS J01GB Other aminoglycosides J01GB14 Plazomicin D10655 Plazomicin sulfate (USAN) <US> USP drug classification [BR:br08302] Antibacterials Aminoglycosides Plazomicin D10655 Plazomicin sulfate (USAN) Drug groups [BR:br08330] Antibacterial DG01447 Aminoglycoside antibiotic DG01833 Plazomicin D10655 Plazomicin sulfate Drug classes [BR:br08332] Antibacterial DG01447 Aminoglycoside antibiotic D10655 Plazomicin sulfate Antimicrobials [BR:br08307] Antibacterials Protein biosynthesis inhibitor Aminoglycoside D10655 Plazomicin sulfate (USAN) <US> New drug approvals in the USA [br08319.html] New molecular entities and new therapeutic biological products D10655 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D10655 Drug groups [BR:br08330] Antibacterial DG01447 Aminoglycoside antibiotic DG01833 Plazomicin Antimicrobials abbreviations [BR:br08327] Antibacterials Protein biosynthesis inhibitor Aminoglycoside DG01833 Plazomicin | ||||||
| Other DBs |
| ||||||
| KCF data | ATOM 46 1 C1x C 9.1223 -17.7189 2 C1z C 9.1223 -19.1143 3 C1y C 10.3782 -19.8120 4 C1y C 11.5642 -19.1143 5 C1y C 11.5642 -17.7189 6 O2x O 10.3782 -17.0212 7 O2a O 12.8201 -17.0212 8 O1a O 12.8201 -19.8817 9 N1b N 10.3782 -21.2073 10 O1a O 7.7270 -19.1143 11 C1a C 8.4246 -20.3701 12 C1a C 9.1223 -21.9748 13 C1y C 14.0061 -16.3235 14 C1y C 15.2620 -17.0212 15 C1x C 16.4480 -16.3235 16 C1y C 16.4480 -14.9282 17 C1y C 15.1922 -14.2305 18 C1y C 14.0061 -14.9282 19 N1b N 15.2620 -18.4166 20 O1a O 12.8201 -14.2305 21 N1a N 17.7039 -14.2305 22 C5a C 16.4480 -19.1143 23 C1c C 17.6341 -18.4166 24 O5a O 16.4480 -20.5096 25 C1b C 18.8202 -19.1143 26 O1a O 17.6341 -17.0212 27 C1b C 20.0062 -18.4166 28 N1a N 21.1923 -19.1143 29 O2a O 15.1922 -12.8351 30 C1y C 16.4480 -12.1374 31 O2x O 17.6341 -12.8351 32 C2y C 18.8202 -12.1374 33 C2x C 18.8202 -10.7420 34 C1x C 17.6341 -10.0444 35 C1y C 16.4480 -10.7420 36 N1a N 15.1922 -10.0444 37 C1b C 20.0760 -12.8351 38 N1b N 20.0760 -14.2305 39 C1b C 21.2621 -14.9282 40 C1b C 22.4481 -14.2305 41 O1a O 23.6342 -14.9282 42 O1d O 26.3552 -19.1143 43 S4a S 26.3552 -20.5096 44 O1d O 26.3552 -21.9050 45 O1d O 27.7505 -20.5096 46 O1d O 24.9598 -20.5096 BOND 47 1 1 2 1 2 2 3 1 3 3 4 1 4 4 5 1 5 5 6 1 6 1 6 1 7 5 7 1 #Down 8 4 8 1 #Down 9 3 9 1 #Up 10 2 10 1 #Up 11 2 11 1 #Down 12 9 12 1 13 13 7 1 #Down 14 13 14 1 15 14 15 1 16 15 16 1 17 16 17 1 18 17 18 1 19 13 18 1 20 14 19 1 #Up 21 18 20 1 #Up 22 16 21 1 #Up 23 19 22 1 24 22 23 1 25 22 24 2 26 23 25 1 27 23 26 1 #Up 28 25 27 1 29 27 28 1 30 17 29 1 #Down 31 30 29 1 #Down 32 30 31 1 33 31 32 1 34 32 33 2 35 33 34 1 36 34 35 1 37 30 35 1 38 35 36 1 #Down 39 32 37 1 40 37 38 1 41 38 39 1 42 39 40 1 43 40 41 1 44 42 43 2 45 43 44 2 46 43 45 1 47 43 46 1 BRACKET 1 23.9400 -22.4000 23.9400 -18.4100 1 28.9100 -18.4100 28.9100 -22.4000 1 x ORIGINAL 1 42 43 44 45 46 REPEAT 1 |