| Entry |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | Perampanel hydrate (JAN); Fycompa (TN) | ||||||||
| Product | FYCOMPA (Eisai) | ||||||||
| Formula | (C23H15N3O)3. 4H2O | ||||||||
| Exact mass | 1119.4068 | ||||||||
| Mol weight | 1120.2152 | ||||||||
| Structure |  | ||||||||
| Class | Neuropsychiatric agent DG03199 Antiepileptic agent DG01569 AMPA receptor antagonist Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate | ||||||||
| Remark |
| ||||||||
| Efficacy | Antiepileptic, AMPA receptor antagonist | ||||||||
| Target | GRIA [HSA:2890 2891 2892 2893] [KO:K05197 K05198 K05199 K05200] | ||||||||
| Pathway |
| ||||||||
| Metabolism | Enzyme: CYP3A [HSA:1576 1577 1551] | ||||||||
| Interaction | |||||||||
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] N NERVOUS SYSTEM N03 ANTIEPILEPTICS N03A ANTIEPILEPTICS N03AX Other antiepileptics N03AX22 Perampanel D10780 Perampanel hydrate (JAN) <JP/US> USP drug classification [BR:br08302] Anticonvulsants Anticonvulsants, Other Perampanel D10780 Perampanel hydrate (JAN) Therapeutic category of drugs in Japan [BR:br08301] 1 Agents affecting nervous system and sensory organs 11 Agents affecting central nervous system 113 Antiepileptics 1139 Others D10780 Perampanel hydrate (JAN) Drug groups [BR:br08330] Neuropsychiatric agent DG03199 Antiepileptic agent DG01569 AMPA receptor antagonist DG01901 Perampanel D10780 Perampanel hydrate Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG01901 Perampanel D10780 Perampanel hydrate Target-based classification of drugs [BR:br08310] Ion channels Ligand-gated ion channels Glutamate (ionotropic), non-NMDA GRIA D10780 Perampanel hydrate (JAN) <JP/US> New drug approvals in the USA [br08319.html] New molecular entities and new therapeutic biological products D10780 New drug approvals in Europe [br08329.html] European public assessment reports (EPAR) authorised medicine D10780 New drug approvals in Japan [br08318.html] Drugs with new active ingredients D10780 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D10780 Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D10780 Drug groups [BR:br08330] Neuropsychiatric agent DG03199 Antiepileptic agent DG01569 AMPA receptor antagonist DG01901 Perampanel Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG01901 Perampanel | ||||||||
| Other DBs |
| ||||||||
| KCF data | ATOM 85 1 C8x C 13.7779 -12.3092 2 C8x C 13.7779 -13.7079 3 C8y C 15.0367 -14.4073 4 C8y C 16.2257 -13.7079 5 C8x C 16.2257 -12.3092 6 C8x C 15.0367 -11.6098 7 C8y C 17.4846 -14.4772 8 C8x C 17.4846 -15.8760 9 C8y C 18.6735 -16.5754 10 C8x C 19.8625 -15.8760 11 N4y N 19.8625 -14.4772 12 C8y C 18.6735 -13.7779 13 C3b C 15.0367 -15.8760 14 N3a N 15.0367 -17.2748 15 C8y C 21.1214 -13.7779 16 C8x C 22.3103 -14.4073 17 C8x C 23.4993 -13.7079 18 C8x C 23.4993 -12.3092 19 C8x C 22.3103 -11.6098 20 C8x C 21.1214 -12.3092 21 C8y C 18.6735 -17.9742 22 N5x N 17.4846 -18.6036 23 C8x C 17.4846 -20.0024 24 C8x C 18.6735 -20.7018 25 C8x C 19.8625 -20.0723 26 C8x C 19.8625 -18.6735 27 O5x O 18.6735 -12.3092 28 O0 O 28.7700 -17.1500 29 C8x C 13.7779 -12.3092 30 C8x C 13.7779 -13.7079 31 C8y C 15.0367 -14.4073 32 C8y C 16.2257 -13.7079 33 C8x C 16.2257 -12.3092 34 C8x C 15.0367 -11.6098 35 C8y C 17.4846 -14.4772 36 C8x C 17.4846 -15.8760 37 C8y C 18.6735 -16.5754 38 C8x C 19.8625 -15.8760 39 N4y N 19.8625 -14.4772 40 C8y C 18.6735 -13.7779 41 O5x O 18.6735 -12.3092 42 C8y C 21.1214 -13.7779 43 C8x C 22.3103 -14.4073 44 C8x C 23.4993 -13.7079 45 C8x C 23.4993 -12.3092 46 C8x C 22.3103 -11.6098 47 C8x C 21.1214 -12.3092 48 C8y C 18.6735 -17.9742 49 N5x N 17.4846 -18.6036 50 C8x C 17.4846 -20.0024 51 C8x C 18.6735 -20.7018 52 C8x C 19.8625 -20.0723 53 C8x C 19.8625 -18.6735 54 C3b C 15.0367 -15.8760 55 N3a N 15.0367 -17.2748 56 C8x C 13.7779 -12.3092 57 C8x C 13.7779 -13.7079 58 C8y C 15.0367 -14.4073 59 C8y C 16.2257 -13.7079 60 C8x C 16.2257 -12.3092 61 C8x C 15.0367 -11.6098 62 C8y C 17.4846 -14.4772 63 C8x C 17.4846 -15.8760 64 C8y C 18.6735 -16.5754 65 C8x C 19.8625 -15.8760 66 N4y N 19.8625 -14.4772 67 C8y C 18.6735 -13.7779 68 O5x O 18.6735 -12.3092 69 C8y C 21.1214 -13.7779 70 C8x C 22.3103 -14.4073 71 C8x C 23.4993 -13.7079 72 C8x C 23.4993 -12.3092 73 C8x C 22.3103 -11.6098 74 C8x C 21.1214 -12.3092 75 C8y C 18.6735 -17.9742 76 N5x N 17.4846 -18.6036 77 C8x C 17.4846 -20.0024 78 C8x C 18.6735 -20.7018 79 C8x C 19.8625 -20.0723 80 C8x C 19.8625 -18.6735 81 C3b C 15.0367 -15.8760 82 N3a N 15.0367 -17.2748 83 O0 O 28.7700 -17.1500 84 O0 O 28.7700 -17.1500 85 O0 O 28.7700 -17.1500 BOND 90 1 1 2 2 2 2 3 1 3 3 4 2 4 4 5 1 5 5 6 2 6 1 6 1 7 4 7 1 8 7 8 2 9 8 9 1 10 9 10 2 11 10 11 1 12 11 12 1 13 7 12 1 14 3 13 1 15 13 14 3 16 11 15 1 17 15 16 2 18 16 17 1 19 17 18 2 20 18 19 1 21 19 20 2 22 15 20 1 23 9 21 1 24 21 22 2 25 22 23 1 26 23 24 2 27 24 25 1 28 25 26 2 29 21 26 1 30 12 27 2 31 29 30 2 32 30 31 1 33 31 32 2 34 32 33 1 35 33 34 2 36 29 34 1 37 32 35 1 38 35 36 2 39 36 37 1 40 37 38 2 41 38 39 1 42 39 40 1 43 35 40 1 44 31 54 1 45 54 55 3 46 39 42 1 47 42 43 2 48 43 44 1 49 44 45 2 50 45 46 1 51 46 47 2 52 42 47 1 53 37 48 1 54 48 49 2 55 49 50 1 56 50 51 2 57 51 52 1 58 52 53 2 59 48 53 1 60 40 41 2 61 56 57 2 62 57 58 1 63 58 59 2 64 59 60 1 65 60 61 2 66 56 61 1 67 59 62 1 68 62 63 2 69 63 64 1 70 64 65 2 71 65 66 1 72 66 67 1 73 62 67 1 74 58 81 1 75 81 82 3 76 66 69 1 77 69 70 2 78 70 71 1 79 71 72 2 80 72 73 1 81 73 74 2 82 69 74 1 83 64 75 1 84 75 76 2 85 76 77 1 86 77 78 2 87 78 79 1 88 79 80 2 89 75 80 1 90 67 68 2 BRACKET 1 13.0900 -21.2100 13.0900 -10.9900 1 23.9400 -10.9900 23.9400 -21.2100 1 3 ORIGINAL 1 1 2 3 4 5 6 7 8 9 10 11 12 27 15 16 17 1 18 19 20 21 22 23 24 25 26 13 14 REPEAT 1 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 1 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 1 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 1 77 78 79 80 81 82 2 26.6000 -18.1300 26.6000 -16.1700 2 29.8900 -16.1700 29.8900 -18.1300 2 4 ORIGINAL 2 28 REPEAT 2 83 84 85 |