| Entry |
|
|---|
| Name |
Telmisartan, amlodipine and hydrochlorothiazide;
Micatrio (TN) |
|---|
| Component |
Telmisartan [DR:D00627], (Amlodipine besylate [DR:D00615] | Amlodipine maleate [DR:D02914] | Amlodipine [DR:D07450]), Hydrochlorothiazide [DR:D00340]
|
|---|
| Class |
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG03231 Antihypertensive
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02924 UGT substrate
|
|---|
| Remark |
| Therapeutic category: | 2149 |
|
|---|
| Efficacy |
Antihypertensive |
|---|
| Comment |
Telmisartan is primarily metabolized by UDP-glucuronosyltransferase (UGT).
Amlodipine is primarily metabolized by CYP3A4.
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA:1576], UGT [KO:K00699]
|
|---|
| Interaction |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D10805 Telmisartan, amlodipine and hydrochlorothiazide
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
D10805 Telmisartan, amlodipine and hydrochlorothiazide
DG03231 Antihypertensive
D10805 Telmisartan, amlodipine and hydrochlorothiazide
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D10805 Telmisartan, amlodipine and hydrochlorothiazide
DG02924 UGT substrate
D10805 Telmisartan, amlodipine and hydrochlorothiazide
Drug classes [BR:br08332]
Cardiovascular agent
DG03231 Antihypertensive
D10805 Telmisartan, amlodipine and hydrochlorothiazide
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10805
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|---|
| Other DBs |
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|---|