| Entry |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | Relugolix (JAN/USAN/INN); Orgovyx (TN) | ||||||||
| Product | ORGOVYX (Myovant Sciences) | ||||||||
| Formula | C29H27F2N7O5S | ||||||||
| Exact mass | 623.1762 | ||||||||
| Mol weight | 623.6304 | ||||||||
| Structure |  | ||||||||
| Class | Transporter substrate DG01665 ABCB1 substrate | ||||||||
| Remark |
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| Efficacy | Anti-endometriosis, Antineoplastic, Gonadotropin-releasing hormone receptor antagonist | ||||||||
| Disease | prostate cancer [DS:H00024] | ||||||||
| Comment | Treatment of prostate cancer, endometriosis, and uterine fibroids | ||||||||
| Target | GNRHR [HSA:2798] [KO:K04280] | ||||||||
| Pathway |
| ||||||||
| Metabolism | Transporter: ABCB1 [HSA:5243] | ||||||||
| Interaction | |||||||||
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS L02 ENDOCRINE THERAPY L02B HORMONE ANTAGONISTS AND RELATED AGENTS L02BX Other hormone antagonists and related agents L02BX04 Relugolix D10888 Relugolix (JAN/USAN/INN) <JP/US> USP drug classification [BR:br08302] Hormonal Agents, Suppressant (Pituitary) Relugolix D10888 Relugolix (JAN/USAN/INN) Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 24 Hormones 249 Miscellaneous 2499 Others D10888 Relugolix (JAN/USAN/INN) Drug groups [BR:br08330] Transporter substrate DG01665 ABCB1 substrate D10888 Relugolix Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Gonadotropin-releasing hormone GNRHR D10888 Relugolix (JAN/USAN/INN) <JP/US> New drug approvals in the USA [br08319.html] New molecular entities and new therapeutic biological products D10888 New drug approvals in Europe [br08329.html] European public assessment reports (EPAR) authorised medicine D10888 New drug approvals in Japan [br08318.html] Drugs with new active ingredients D10888 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D10888 Drug metabolizing enzymes and transporters [br08309.html] Drug transporters D10888 | ||||||||
| Other DBs |
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| KCF data | ATOM 44 1 C8y C 20.1906 -21.2472 2 N4y N 20.1906 -19.8560 3 C8y C 19.0081 -19.1604 4 C8y C 17.7560 -19.8560 5 C8y C 17.7560 -21.2472 6 N4y N 19.0081 -21.9428 7 C8y C 16.4343 -19.4386 8 C8y C 15.6692 -20.5516 9 S2x S 16.4343 -21.6645 10 O5x O 19.0081 -17.7692 11 O5x O 21.3731 -21.9428 12 C8y C 21.3731 -19.1604 13 C8x C 22.5557 -19.8560 14 C8x C 23.8077 -19.1604 15 C8y C 23.8077 -17.7692 16 N5x N 22.6252 -17.0735 17 N5x N 21.3731 -17.7692 18 O2a O 24.9903 -17.0735 19 C1a C 26.1728 -17.7692 20 C1b C 19.0081 -24.3100 21 C8y C 14.2779 -20.5516 22 C8x C 13.5823 -19.3690 23 C8x C 12.1911 -19.3690 24 C8y C 11.4955 -20.5516 25 C8x C 12.1911 -21.7341 26 C8x C 13.5823 -21.7341 27 N1b N 10.1043 -20.5516 28 C1b C 16.0170 -18.1170 29 N1c N 14.6283 -17.8381 30 C1a C 13.5161 -18.6562 31 C1a C 14.5129 -16.4569 32 C8y C 20.2352 -25.0190 33 C8y C 20.2347 -26.3900 34 C8x C 21.4468 -27.0905 35 C8x C 22.6595 -26.3909 36 C8x C 22.6601 -25.0200 37 C8y C 21.4479 -24.3195 38 X F 19.0185 -27.0916 39 X F 21.4490 -22.8903 40 C5a C 9.3912 -21.7988 41 N1b N 7.9804 -21.8050 42 O5a O 10.0811 -22.9818 43 O2a O 7.2596 -20.5696 44 C1a C 5.8800 -20.5761 BOND 48 1 1 2 1 2 2 3 1 3 3 4 1 4 4 5 2 5 5 6 1 6 1 6 1 7 4 7 1 8 7 8 2 9 8 9 1 10 5 9 1 11 3 10 2 12 1 11 2 13 2 12 1 14 12 13 2 15 13 14 1 16 14 15 2 17 15 16 1 18 16 17 2 19 12 17 1 20 15 18 1 21 18 19 1 22 6 20 1 23 8 21 1 24 21 22 2 25 22 23 1 26 23 24 2 27 24 25 1 28 25 26 2 29 21 26 1 30 24 27 1 31 7 28 1 32 28 29 1 33 29 30 1 34 29 31 1 35 20 32 1 36 32 33 2 37 33 34 1 38 34 35 2 39 35 36 1 40 36 37 2 41 32 37 1 42 33 38 1 43 37 39 1 44 27 40 1 45 40 41 1 46 40 42 2 47 41 43 1 48 43 44 1 |