Difelikefalin acetate


Entry
D10890                      Drug                                   
Name
Difelikefalin acetate (JAN);
Korsuva (TN)
Product
KORSUVA (Vifor (International))
Formula
C36H53N7O6. (C2H4O2)x
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01562  kappa-Opioid receptor agonist
Remark
ATC code: V03AX04
Chemical structure group: DG02914
Product (DG02914): D10890<US>
Efficacy
Analgesic, Antipruritic, Opioid receptor agonist
Comment
Treatment of moderate-to-severe pruritus associated with chronic kidney disease in adults undergoing hemodialysis
Target
OPRK1 [HSA:4986] [KO:K04214]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AX Other therapeutic products
     V03AX04 Difelikefalin
      D10890  Difelikefalin acetate (JAN) <US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Dermatitis and Pruitus Agents, Other
    Difelikefalin
     D10890  Difelikefalin acetate (JAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01562  kappa-Opioid receptor agonist
    DG02914  Difelikefalin
     D10890  Difelikefalin acetate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRK1
     D10890  Difelikefalin acetate (JAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10890
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10890
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10890
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01562  kappa-Opioid receptor agonist
    DG02914  Difelikefalin
Other DBs
CAS: 1024829-44-4
PubChem: 336445208
KCF data

ATOM        53
            1   C1z C     8.6800  -16.7300
            2   C1x C     8.6800  -18.1300
            3   C1x C     9.8924  -18.8300
            4   N1y N    11.1049  -18.1300
            5   C1x C    11.1049  -16.7300
            6   C1x C     9.8924  -16.0300
            7   N1a N     8.6800  -15.3300
            8   C6a C     7.4676  -17.4300
            9   O6a O     6.2721  -16.7396
            10  O6a O     7.4675  -18.8298
            11  C5a C    12.3360  -18.8410
            12  C1c C    13.5412  -18.1453
            13  O5a O    12.3357  -20.2299
            14  N1b N    14.7235  -18.8281
            15  C1b C    13.5416  -16.7304
            16  C1b C    14.7305  -16.0441
            17  C1b C    14.7310  -14.6303
            18  C1b C    15.9203  -13.9439
            19  C5a C    15.9175  -18.1388
            20  C1c C    17.1054  -18.8248
            21  O5a O    15.9177  -16.7303
            22  N1b N    18.2965  -18.1371
            23  C1b C    17.1055  -20.2298
            24  C5a C    19.4859  -18.8239
            25  C1c C    20.6762  -18.1366
            26  O5a O    19.4860  -20.2298
            27  C1c C    15.8740  -20.9410
            28  N1b N    21.8661  -18.8237
            29  C1b C    20.6764  -16.7302
            30  C5a C    23.0562  -18.1365
            31  C1c C    24.2461  -18.8236
            32  N1a N    15.9208  -12.5303
            33  C8y C    19.4442  -16.0186
            34  C8x C    19.4446  -14.6301
            35  C8x C    18.2324  -13.9297
            36  C8x C    17.0198  -14.6294
            37  C8x C    17.0194  -16.0179
            38  C8x C    18.2316  -16.7182
            39  O5a O    23.0563  -16.7302
            40  C1b C    25.4362  -18.1365
            41  N1a N    24.2462  -20.2298
            42  C8y C    26.6261  -18.8236
            43  C8x C    26.6261  -20.2298
            44  C8x C    27.8386  -20.9297
            45  C8x C    29.0510  -20.2297
            46  C8x C    29.0510  -18.8236
            47  C8x C    27.8385  -18.1236
            48  C1a C    14.6689  -20.2453
            49  C1a C    15.8742  -22.3299
            50  C6a C    26.8100  -14.0700
            51  C1a C    28.0224  -14.7700
            52  O6a O    25.5976  -14.7700
            53  O6a O    26.8100  -12.6700
BOND        54
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     1   8 1
            9     8   9 1
            10    8  10 2
            11    4  11 1
            12   11  12 1
            13   11  13 2
            14   12  14 1
            15   12  15 1 #Up
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   14  19 1
            20   19  20 1
            21   19  21 2
            22   20  22 1
            23   20  23 1 #Down
            24   22  24 1
            25   24  25 1
            26   24  26 2
            27   23  27 1
            28   25  28 1
            29   25  29 1 #Up
            30   28  30 1
            31   30  31 1
            32   18  32 1
            33   29  33 1
            34   33  34 2
            35   34  35 1
            36   35  36 2
            37   36  37 1
            38   37  38 2
            39   33  38 1
            40   30  39 2
            41   31  40 1
            42   31  41 1 #Up
            43   40  42 1
            44   42  43 2
            45   43  44 1
            46   44  45 2
            47   45  46 1
            48   46  47 2
            49   42  47 1
            50   27  48 1
            51   27  49 1
            52   50  51 1
            53   50  52 1
            54   50  53 2
BRACKET     1    23.4500  -15.6800   23.4500  -11.4800
            1    30.2400  -11.4800   30.2400  -15.6800
            1  x
 ORIGINAL  1   50  51  52  53
 REPEAT    1