Glycopyrronium tosylate


Entry
D10939                      Drug                                   
Name
Glycopyrronium tosylate (USAN);
Glycopyrronium tosilate hydrate (JAN);
Glycopyrronium tosylate monohydrate;
Qbrexza (TN);
Rapifort (TN)
Product
QBREXZA (Journey Medical Corporation), QBREXZA (Journey Medical Corporation)
Formula
C19H28NO3. C7H7O3S. H2O
Exact mass
507.2291
Mol weight
507.6395
Structure
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Remark
Therapeutic category: 1259
ATC code: D11AA01
Chemical structure group: DG02467
Product (DG02467): D00540<JP/US> D10939<JP/US>
Efficacy
Muscarinic acetylcholine receptor antagonist
Comment
Treatment of hyperhidrosis
Target
CHRM [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AA Antihidrotics
     D11AA01 Glycopyrronium
      D10939  Glycopyrronium tosylate (USAN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatological Agents, Other
   Dermatological Agents, Miscellaneous
    Glycopyrronium
     D10939  Glycopyrronium tosylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   125  Diaphoretics, anhidrotics
    1259  Others
     D10939  Glycopyrronium tosylate (USAN); Glycopyrronium tosilate hydrate (JAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG02467  Glycopyrronium
    D10939  Glycopyrronium tosylate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D10939  Glycopyrronium tosylate (USAN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10939
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10939
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG02467  Glycopyrronium
Other DBs
CAS: 1624259-25-1
PubChem: 342581793
KCF data

ATOM        35
            1   C1d C    16.0531  -16.8474
            2   C7a C    14.9201  -17.4847
            3   O7a O    13.7162  -16.8474
            4   O6a O    14.9201  -18.9010
            5   C1y C    12.4415  -17.5556
            6   C1x C    11.3628  -16.7766
            7   C1x C    12.0408  -18.9214
            8   N2y N    10.2055  -17.5679 #+
            9   C1x C    10.6793  -18.8818
            10  C1y C    17.2717  -17.5692
            11  C1x C    17.7108  -18.8972
            12  C1x C    19.1120  -18.8938
            13  C1x C    19.5416  -17.5600
            14  C1x C    18.4060  -16.7393
            15  C8y C    16.0531  -15.4311
            16  C8x C    17.2797  -14.7229
            17  C8x C    17.2797  -13.3067
            18  C8x C    16.0531  -12.5985
            19  C8x C    14.8266  -13.3067
            20  C8x C    14.8266  -14.7229
            21  O1a O    17.1381  -15.9976
            22  C1a C     8.9790  -16.8598
            23  C1a C     8.9790  -18.2760
            24  C8x C    22.1903  -16.2402
            25  C8x C    22.1903  -17.6402
            26  C8y C    23.4027  -18.3402
            27  C8x C    24.6152  -17.6402
            28  C8x C    24.6152  -16.2402
            29  C8y C    23.4027  -15.5402
            30  C1a C    23.4027  -19.7400
            31  S4a S    23.4027  -14.1404
            32  O1d O    23.4027  -12.7404 #-
            33  O1d O    24.8027  -14.1404
            34  O1d O    22.0027  -14.1404
            35  O0  O    28.3504  -16.8002
BOND        36
            1     1   2 1
            2     2   3 1
            3     2   4 2
            4     3   5 1
            5     5   6 1
            6     5   7 1
            7     6   8 1
            8     7   9 1
            9     8   9 1
            10    1  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   10  14 1
            16    1  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   15  20 2
            23    1  21 1
            24    8  22 1
            25    8  23 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   28  29 2
            31   24  29 1
            32   26  30 1
            33   29  31 1
            34   31  32 1
            35   31  33 2
            36   31  34 2