Larcaviximab


Entry
D10948                      Drug                                   
Name
Larcaviximab (USAN);
ZMapp (TN)
Sequence
(Heavy chain)
EVQLQESGPE LEMPGASVKI SCKASGSSFT GFSMNWVKQS NGKSLEWIGN IDTYYGGTTY
NQKFKGKATL TVDKSSSTAY MQLKSLTSED SAVYYCARSA YYGSTFAYWG QGTLVTVSAA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKRVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Light chain)
DIQMTQSPAS LSASVGETVT ITCRASENIY SYLAWYQQKQ GKSPQLLVYN AKTLIEGVPS
RFSGSGSGTQ FSLKINSLQP EDFGSYFCQH HFGTPFTFGS GTELEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV 1DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H146-H202, H222-L214, H228-H'228, H231-H'231, H263-H323, 369-H427, H'22-H96, H'146-H'202, H'222-L'214, H'263-H'323, H'369-H'427, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Antiviral
Comment
Monoclonal antibody
Treatment of Ebola virus disease
Target
Ebolavirus envelope glycoprotein [KO:K24534]
  Pathway
ko03230  Viral genome structure
Brite
Antimicrobials [BR:br08307]
 Antivirals
  Entry, fusion or uncoating inhibitor
   Ebolavirus glycoprotein
    D10948  Larcaviximab (USAN)
Other DBs
CAS: 1792982-56-9
PubChem: 350078325